AutismKB 2.0

Annotation Detail for PTBP2


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Basic Information Top
Gene Symbol:PTBP2 ( FLJ34897,PTB,PTBLP,brPTB,nPTB,nPTB5,nPTB6,nPTB7,nPTB8 )
Gene Full Name: polypyrimidine tract binding protein 2
Band: 1p21.3
Quick LinksEntrez ID:58155; OMIM: 608449; Uniprot ID:PTBP2_HUMAN; ENSEMBL ID: ENSG00000117569; HGNC ID: 17662
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2120Rabies
Desease Name
PSYCH
schizophrenia
Desease Name
Body mass index
Schizophrenia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PTBP2 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PTBP2 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTBP2 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTBP2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTBP2 mRNAdecreases expression 17557909
D015735 Mifepristone Mifepristone results in increased expression of PTBP2 mRNAincreases expression 17584828
D010634 Phenobarbital Phenobarbital results in increased expression of PTBP2 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of PTBP2 mRNAincreases expression 18301758
18445702
D011374 Progesterone Progesterone affects the expression of PTBP2 mRNAaffects expression 17251523
D013629 Tamoxifen Tamoxifen affects the expression of PTBP2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.2117614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 2.2118425577 21152245 18629630 18821012 19155303 19487384 15668708 16273361 18815881 19084267 17893378 19200415 16202921 17440819 18855134 18984771 15565566 21138602 19189212 19011961 20544844 19288272 19289846 20065188 20005174 16873071 19189210 17242785 11161223 19059307 18351453 20390343 19103187 16818667 19142967 19410462 19115204 19066611 20135344 17261762 19221464 19244106 20859285 18997820 17049068
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416011737 3786805 16097048 16192424 16124888 10355542 15673190 15721981 16227642 18705752 15700767 16050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.793084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7918788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7917173139 6705139 1701930 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2516919318 15861022 17333356 16105132 17110522 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9117562736 15619225 14986274 19923254 10915739 11743745 16485898 10663392 11461765 12540782 18071297 14725611 19416960 12153990 17906064 11529661 11834606 19164858 16227642 16781746 12392966 18713872 16109766 11739529 15968718 12594235 10774834 14550746 11287661 19420014 19085960 19739265 19370779 2444490 16393943 12958197 16177239 12705907 16081117 17522070 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.919327722 7440962 7120509 10915739 15998439 16227642 10092053 21278145 6884620 16177239 17522070 19085960 11566570 2869522 3732212 15027814 7179309 4309450 19336974 3786805 6623471 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.7719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1720544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Mifepristone 10.0816134523
MESH:D004715 Endometriosis Progesterone 10.0816134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5412795759 15959796 16045604 17595544 12631006 19224547 16239168 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5415345470
MESH:D005234 Fatty Liver pirinixic acid 20.5420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.5414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7118705752
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Progesterone 5.4915869954
MESH:D007249 Inflammation Tamoxifen 5.4919457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2118625569
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9821278145 11408273 16239168 17157831 11903743 16943688 16221502 17334410 17174718
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5618395914 16015684 17481882 18418968 13678700 12666154 18251166 16033810 12546737 14620537 18187930 18054572 18412020 17976157 17869086 15876570 18472332 17698563 17631135 14716496 15818738 17823541 15338365 20821823 16136751 16011737 17766677 15362042 16192424 18705752 18277467 15650968 12632512 15925388 17525996 17944888 16248980 18420326 16638106 12389079 17761835 12445421 17708605 12445418 17922224 17640975 15730626 18317297 12898905 18395095 15931870 12741479 18210741 12609069 15673190 15893842 17714472 15959796 12649538 18263696 12958196 18481824 17805973 18339082 12632514 18279442 18376398 16116963 18472094 18429990 14748882 15057751 17557913 10355542 18156304 14724832 17721639 15052691 18006644 17565644 15996030 14512876 11481614 18205269 18166357 15370692 16027843 16097048 14716833 17900296 12667390 15123356 12586293
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5618564211
MESH:D008107 Liver Diseases Acetaminophen 6.7519460945 19784758 16611625 12969438 11587558 19014921 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7515830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.7519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2719294768
MESH:D008113 Liver Neoplasms Phenobarbital 11.2715975961 19812893 8742319 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 11.2715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.2716684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.3818308698 2563599 6150874 1399818 17172636
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5016827153 19196722 11731420 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Mifepristone 5.3916525653
MESH:D010051 Ovarian Neoplasms Progesterone 5.3916525653 17393432
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures Phenobarbital 2.823137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.8415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.8419457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4216712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33935
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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