AutismKB 2.0

Annotation Detail for CXCL16


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Basic Information Top
Gene Symbol:CXCL16 ( CXCLG16,SR-PSOX,SRPSOX )
Gene Full Name: chemokine (C-X-C motif) ligand 16
Band: 17p13.2
Quick LinksEntrez ID:58191; OMIM: 605398; Uniprot ID:CXL16_HUMAN; ENSEMBL ID: ENSG00000161921; HGNC ID: 16642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500406Chemokine receptors bind chemokines
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1717Cholangitis
1766Renal Cell cancer
1771Neurilemmoma
1781Rheumatoid arthritis
1831Prostate cancer
1871Hepatitis
1918Atherosclerosis
1967Heart valve disease
1998Enteritis
2087Bacterial infection
2106Pancreas cancer
Desease Name
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001554 Benzene Benzene affects the expression of CXCL16 mRNAaffects expression 17119257
D001554 Benzene Benzene results in increased expression of CXCL16 mRNAincreases expression 15929907
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CXCL16 mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CXCL16 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of CXCL16 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CXCL16 mRNAaffects cotreatment|increases expression 18164116
C006253 pirinixic acid pirinixic acid results in decreased expression of CXCL16 mRNAdecreases expression 17426115
D014212 Tretinoin Tretinoin results in increased expression of CXCL16 mRNAincreases expression 16142401
D014212 Tretinoin Tretinoin results in increased secretion of CXCL16 proteinincreases secretion 16142401
C025643 vinclozolin vinclozolin affects the expression of CXCL16 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 7.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2416434500 19052882 17162532 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000741 Anemia, Aplastic Benzene 4.5511369114 17661222 14761424
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8016206674 16197459
MESH:D001855 Bone Marrow Diseases Benzene 5.6116183116
MESH:D001943 Breast Neoplasms Benzene 1.9911921183 17162533
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D001943 Breast Neoplasms Tretinoin 1.9916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816227642 16192424 15673190 16097048 15721981 16124888 15700767 16011737 18705752 3786805 16050911 10355542
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7819519916 20214788 19539802 17761372 20084675 18691550 17978847 18210153 16807293 19418558 17138121 10672840 19701751 16878318 19394651 19208518 19171122 18788625 18785209 10737359 20524982 17055752 18506893 17173139 11831363 20727157 19822196 19919837 20007298 19052882 16540662 16288022 20935162 16328049 16830150 20512989 19107877 16681979 16698587 18665156 3581430 18494052 19335982 20432363 21159647 16935385 18978308 18393292 19383236 3084413 16779866 18056438 17162532 16569478 20101231 16502159 17428255 20514400 18971187
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.781917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1417174075 7505956 21159647 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Benzene 2.9415643154
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.949224671 9125849 8800419 9664655 9211117 10589399 9142499 16925845 14991402 17551590
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003872 Dermatitis Benzene 5.0715902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.119327722 15027814 4309450 7440962 10915739 19336974 16177239 11566570 17522070 3732212 16227642 6623471 19085960 7179309 15968718 15998439 2869522 7120509 21278145 3786805 6884620 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.1119107877
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8716045604 12631006 17595544 15959796 16239168 19224547 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 20.8719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 20.8719236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 16.6618705752
MESH:D005355 Fibrosis Cyclosporine 16.6612168785 12639820
MESH:D005355 Fibrosis Tretinoin 16.6617994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006402 Hematologic Diseases Benzene 4.9116183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Benzene 5.6417940673
MESH:D006973 Hypertension Cyclosporine 5.6410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Benzene 6.9017119257 15935818 14694614 18335105
MESH:D007938 Leukemia Tretinoin 6.9017143497
MESH:D007951 Leukemia, Myeloid Benzene 10.5017506065
MESH:D007951 Leukemia, Myeloid Tretinoin 10.5016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.2119478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3017712046 9834237 17368321 19642359 17107899 19035177 16766008 16891316 17339181 19075265 17361223 16788101 12679006 16823087 16935935 17301526 17217047 17294898 17649720 19225113 16140955 17506722 16331271 19029980 15748426
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0116943688 17174718 11408273 17334410 11903743 16239168 21278145 16221502 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0118665156 19638242 18407596 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5918263696 15362042 16136751 16097048 16116963 20821823 15931870 13678700 16638106 12586293 17976157 12609069 16011737 18395095 15052691 11481614 14748882 12741479 17481882 18205269 18317297 18420326 17565644 15893842 15959796 12958196 12649538 15650968 18472332 15996030 17869086 15057751 17922224 18705752 16027843 17944888 17721639 14724832 12667390 12632512 17714472 16192424 15730626 17631135 16248980 18166357 12389079 18481824 12666154 16033810 15338365 17900296 18376398 14716833 15673190 17766677 17708605 15123356 18412020 18339082 14512876 18187930 17761835 15925388 18054572 12632514 12445421 16015684 15818738 10355542 17640975 12546737 12445418 14716496 18277467 18418968 17557913 18429990 18210741 12898905 18006644 18156304 15370692 17698563 18395914 17525996 14620537 15876570 17805973 18251166 18279442 17823541 18472094
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5918397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2416964402 15830285 17285989 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.3821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.3819256749 20137499 18978307 19090486 19255062 18754104 19996281 19254457 20583210 18648771 20118626 18644402 16942905 2422723 20501860 19850985 2862719 12771043 21047994 20101389 19427195 20434301 19073162 15885732 21167192 20452335 21071580 19294768 19833225 18977376 19642983 19551842 9163691 15175105 19690152 19812893 19499222 20492335 12112319 19638242 20405173 10737359 21278145 19426721
MESH:D008113 Liver Neoplasms pirinixic acid 11.3820007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Benzene 15.3812562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.3818164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.3819519916 18544905 19126423 2563599 18282651 18079962 17174075 19004024 18093689 18775883 21159647 19009564 3124819 16267830 9362446 17854601 16842330 19539802 18308698 18164116 18253720 17942915
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1814698565
MESH:D008175 Lung Neoplasms Benzene 2.7512562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7521163286 20970405 6695378 20512841
MESH:D008223 Lymphoma Benzene 3.9017584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.7812562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.4511921183
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma Benzene 3.8317119195
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Tretinoin 5.2616946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Benzene 8.0015643154
MESH:D009436 Neural Tube Defects Tretinoin 8.009142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases Benzene 4.4117178637 17119257 16737584 15727169 17479406 15935809 15576619 15612468 15913788
MESH:D010051 Ovarian Neoplasms Benzene 5.2912562636
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2916936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4915976015
MESH:D011230 Precancerous Conditions Cyclosporine 9.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.672563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013274 Stomach Neoplasms Benzene 3.5512562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5518456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.5517261132
MESH:D013953 Thymus Neoplasms Benzene 5.2910850423
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.787505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014594 Uterine Neoplasms Benzene 4.6112562636
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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