AutismKB 2.0

Annotation Detail for PVT1


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Basic Information Top
Gene Symbol:PVT1 ( MGC21751,NCRNA00079 )
Gene Full Name: Pvt1 oncogene (non-protein coding)
Band: 8q24.21
Quick LinksEntrez ID:5820; OMIM: 165140; Uniprot ID:; ENSEMBL ID: ; HGNC ID: 9709
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001554 Benzene Benzene results in increased expression of PVT1 mRNAincreases expression 15122651
15120971
D005472 Fluorouracil Fluorouracil results in decreased expression of PVT1 mRNAdecreases expression 16709241
C025462 sulindac sulfide sulindac sulfide results in increased expression of PVT1 mRNAincreases expression 12734198
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of PVT1 mRNAincreases expression 18087596
D014212 Tretinoin Tretinoin results in decreased expression of PVT1 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4917638652
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 6.1415814487
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1418759972
MESH:D000740 Anemia Fluorouracil 4.0616511603 17963324 15504547
MESH:D000741 Anemia, Aplastic Benzene 4.6411369114 14761424 17661222
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.1219898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.1216292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001855 Bone Marrow Diseases Benzene 5.8416183116
MESH:D001943 Breast Neoplasms Benzene 2.0217162533 11921183
MESH:D001943 Breast Neoplasms Fluorouracil 2.0218357371 19217205 15136595 18608205 16595493 16557594 16110121
MESH:D001943 Breast Neoplasms Tretinoin 2.0216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 3.8517121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2617088986 18930000 17045692 17971768 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.261917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.4312391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.4311212258
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 8.1817066447 16757204 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 8.1811212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.1816051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817018589 15001691 16340194 16510598 17016597 18772588 17287894 17725105 17172411 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017454858 17695437 16303861 18802399 18448328 20501625 15289873 16524972 18383874 16282729 18509181 17401013 17094418 16331619 18288408 16391804 14970324 15148649 17594712 17255274 18949393 17016601
MESH:D019465 Craniofacial Abnormalities Benzene 2.9615643154
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.969142499 17551590 9211117 9125849 9224671 16925845 9664655 8800419 14991402 10589399
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D003872 Dermatitis Benzene 5.2515902427
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216785472 17638652 15173087 16481741 16337965
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.5515102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006402 Hematologic Diseases Benzene 5.0616183116
MESH:D006689 Hodgkin Disease marker/mechanism 21037568
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Benzene 3.2017940673
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4918590791
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6116985049
MESH:D007938 Leukemia Benzene 7.0618335105 15935818 17119257 14694614
MESH:D007938 Leukemia Tretinoin 7.0617143497
MESH:D007951 Leukemia, Myeloid Benzene 10.9517506065
MESH:D007951 Leukemia, Myeloid Tretinoin 10.9519285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.2519478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2516294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717361223 17217047 17301526 19642359 19075265 9834237 19029980 17107899 16935935 16788101 19225113 16891316 16331271 17294898 17506722 16140955 16766008 16823087 15748426 17712046 17368321 17339181 12679006 19035177 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Fluorouracil 2.5817045692 18383874 15113037 16603448
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.4912562636
MESH:D017563 Lung Diseases, Interstitial Benzene 5.4214698565
MESH:D008175 Lung Neoplasms Benzene 3.8712562636
MESH:D008175 Lung Neoplasms Fluorouracil 3.8715246190
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.8712111688 16288123 3440675 11091918
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D008223 Lymphoma Benzene 3.9817119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.9812562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.5111921183
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009062 Mouth Neoplasms Fluorouracil 9.8818986760 16757204
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.8815006635
MESH:D009101 Multiple Myeloma Benzene 3.9117119195
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009369 Neoplasms Fluorouracil 5.6618239605 18600527 16928823
MESH:D009369 Neoplasms Tretinoin 5.6616594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Benzene 8.2315643154
MESH:D009436 Neural Tube Defects Tretinoin 8.239142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D009784 Occupational Diseases Benzene 4.5316737584 17119257 15913788 17479406 15727169 17178637 15612468 15576619 15935809
MESH:D010051 Ovarian Neoplasms Benzene 5.3812562636
MESH:D010051 Ovarian Neoplasms Tretinoin 5.3816936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6916500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6915976015
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3416160472 15538739 18286688 18722050
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 5.1118410779
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.5818590791
MESH:D012878 Skin Neoplasms Tretinoin 6.5816467112
MESH:D013274 Stomach Neoplasms Benzene 3.6212562636
MESH:D013274 Stomach Neoplasms Fluorouracil 3.6218396642 17498489 16424979 19015929 19084572 15786421 17172411 18567086 16951190 17522103
MESH:D013274 Stomach Neoplasms Tretinoin 3.6217261132
MESH:D013953 Thymus Neoplasms Benzene 5.5010850423
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 11.0116280240
MESH:D014062 Tongue Neoplasms Tretinoin 11.0116051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.4512846360
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.6316803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.6316129372
MESH:D014594 Uterine Neoplasms Benzene 11.5712562636
MESH:D014594 Uterine Neoplasms sulindac sulfide 11.5718645019
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34053
    • No data
    Releated disease ID Related disease Name
    PA444684Kidney Failure, Chronic
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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