AutismKB 2.0

Annotation Detail for PEX5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PEX5 ( FLJ50634,FLJ50721,FLJ51948,PTS1-BP,PTS1R,PXR1 )
Gene Full Name: peroxisomal biogenesis factor 5
Band: 12p13.31
Quick LinksEntrez ID:5830; OMIM: 600414; Uniprot ID:PEX5_HUMAN; ENSEMBL ID: ENSG00000139197; HGNC ID: 9719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00205Zellweger syndrome spectrum
Peroxisomal diseases
Genetic disorders
Desease IDDesease Name
2032Kidney disease
2060Glaucoma
2126Encephalopathies
No data
No data
Desease Name
Adrenoleukodystrophy, neonatal
Zellweger syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PEX5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PEX5 mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of PEX5 mRNAaffects expression 16079270
C058317 arsenic disulfide arsenic disulfide results in decreased expression of PEX5 mRNAdecreases expression 12890387
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PEX5 mRNAaffects expression 16079270
C006253 pirinixic acid pirinixic acid results in increased expression of PEX5 mRNAincreases expression 18301758
17426115
D020849 Raloxifene Raloxifene affects the expression of PEX5 mRNAaffects expression 16079270
D014810 Vitamin E Vitamin E results in increased expression of PEX5 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
OMIM:202370 ADRENOLEUKODYSTROPHY, AUTOSOMAL NEONATAL FORM marker/mechanism
MESH:D000419 Albuminuria Raloxifene 4.8817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Raloxifene 2.6416912660 15775269 17893378 17049068 15572757 17952589 15758505 17242785 17261762 17440819 17595753 16837676
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3315861022 16919318 17333356 17681005 11677210 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1515920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9115619225 11743745 14550746 16081117 12392966 18713872 10663392 10915739 19085960 14725611 16393943 19739265 17562736 11287661 12594235 18071297 19164858 17522070 10774834 16109766 11529661 11421492 16177239 15968718 16485898 11461765 16227642 17906064 11834606 12705907 12540782 16781746 19370779 19416960 12958197 11739529 2444490 14986274 12153990 19923254 19420014
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema pirinixic acid 7.7012083418
MESH:D004487 Edema Raloxifene 7.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0715845917
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5615345470
MESH:D005234 Fatty Liver pirinixic acid 14.5620131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.5617473493
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia Acetaminophen 8.8216870215
MESH:D006930 Hyperalgesia Alendronate 8.8216769263
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Raloxifene 2.9415787275 17577099
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 6.3915629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 5.0812421474
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 12969438 19460945 16611625 16610002 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 16377806 15890375
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D010024 Osteoporosis Alendronate 8.2517882678
MESH:D010024 Osteoporosis Raloxifene 8.2517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917823083 17893378 15758505 15579764
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3716536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D020521 Stroke Raloxifene 9.3616837676
MESH:D020521 Stroke Vitamin E 9.3616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4716049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4717572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D015211 Zellweger Syndrome marker/mechanism
Pathway ID Pathway Name
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved