AutismKB 2.0

Annotation Detail for PYGL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PYGL ( GSD6 )
Gene Full Name: phosphorylase, glycogen, liver
Band: 14q22.1
Quick LinksEntrez ID:5836; OMIM: 232700; Uniprot ID:PYGL_HUMAN; ENSEMBL ID: ENSG00000100504; HGNC ID: 9725
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5941glycogen degradation II
PWY-5767glycogen degradation III
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway IDPathway Name
500680Glycogen breakdown (glycogenolysis)
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of carbohydrate metabolism
H00069Glycogen storage disease (GSD)
Genetic disorders
Desease IDDesease Name
1904Diabetes mellitus
No data
No data
Desease Name
Glycogen storage disease VI
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PYGL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PYGL mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PYGL mRNAincreases expression 18648102
C031335 4-hydroxyacetophenone 4-hydroxyacetophenone binds to PYGL proteinaffects binding 15236443
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of PYGL mRNAaffects cotreatment|increases expression 17093179
D000082 Acetaminophen Acetaminophen affects the expression of PYGL mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of PYGL mRNAdecreases expression 17522070
C109238 acyline acyline results in increased expression of PYGL mRNAincreases expression 17510436
D000638 Amiodarone Amiodarone affects the expression of PYGL mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PYGL mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of PYGL mRNAincreases expression 20458559
D001241 Aspirin Aspirin binds to PYGL proteinaffects binding 15236443
D001553 Benzbromarone Benzbromarone affects the expression of PYGL mRNAaffects expression 19483382
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PYGL mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PYGL mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PYGL mRNAaffects expression 15963342
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of PYGL mRNAdecreases expression 17522070
D002725 Chloroform Chloroform results in decreased expression of PYGL mRNAdecreases expression 17522070
D002994 Clofibrate Clofibrate affects the expression of PYGL mRNAaffects expression 19483382
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of PYGL mRNAaffects cotreatment|increases expression 17093179
D004041 Dietary Fats Dietary Fats results in decreased expression of PYGL mRNAdecreases expression 18042831
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of PYGL mRNAdecreases expression 17522070
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PYGL mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PYGL mRNAincreases expression 17557909
D005001 Ethionine Ethionine affects the expression of PYGL mRNAaffects expression 19483382
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of PYGL mRNAdecreases expression 17522070
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of PYGL mRNAdecreases expression 17616710
C002741 N-nitrosomorpholine N-nitrosomorpholine results in decreased expression of PYGL proteindecreases expression 2885971
D009853 Omeprazole Omeprazole affects the expression of PYGL mRNAaffects expression 19483382
C041786 palm oil palm oil results in decreased expression of PYGL mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of PYGL mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid affects the expression of PYGL mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PYGL mRNAaffects expression 19483382
C031280 pyrazole pyrazole results in decreased expression of PYGL mRNAdecreases expression 17945193
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PYGL mRNAaffects cotreatment|increases expression 17942748
D013752 Tetracycline Tetracycline results in decreased expression of PYGL mRNAdecreases expression 17522070
D013853 Thioacetamide Thioacetamide affects the expression of PYGL mRNAaffects expression 19483382
D014635 Valproic Acid Valproic Acid results in increased expression of PYGL mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2315322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6419490988
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 3.9911798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.563712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3217497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.2118057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.2117460149
MESH:D001161 Arteriosclerosis Dietary Fats 8.8515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.4320485159 12372130
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517157402 20603192 19232924 18940202 18396377 15238991 18775368 18985861 18316065 18558336 16609825 17507914 18177632 19460635 17688650
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6911289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9120046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 59.8419483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 59.8416206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 59.8419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 59.8419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 59.8419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 59.8419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 59.8419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 59.8419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 59.8412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 59.8419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.338888407
MESH:D001919 Bradycardia Phenylephrine 4.2215306635
MESH:D001932 Brain Neoplasms Aspirin 4.1415481559
MESH:D001943 Breast Neoplasms Aspirin 1.9815161893
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0311589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4616124888 16227642 3786805 15673190 16097048 15721981 18705752 15700767 16011737 16192424 10355542 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 2885971
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 18.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.743084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 18.7411135700 15553829 15073043 14691202 16217749
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.741701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.7418788625
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 18.748364915 2885971 9311599 1967229 15543204 1917145 15010824 19383236 16935385 9466558 1701930 11509945 9029167 10629087 19335982
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.7417997003
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.607296757
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 6.607921415 1429202
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8412490120
MESH:D006332 Cardiomegaly Phenylephrine 6.2811754973 15728586 16170337 17124262 17287366 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2816120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002386 Cataract Acetaminophen 2.3910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.986135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.987505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 9.981399818
MESH:D002637 Chest Pain Omeprazole 4.7815447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6418291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8712912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 17.3218590720 19486331 12927374 15913567 7624871 16629650 18164287 15500046
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.329022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.3216105132 17110522 16919318 17333356 17681005 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 17.3219176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.5210220858 19407337
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 15668235 16354765 12621046 15340226
MESH:D003110 Colonic Neoplasms Aspirin 2.9312411196
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7420501625
MESH:D015179 Colorectal Neoplasms Aspirin 2.7417047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5510525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5517688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.8318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5018759878 14531868 12868966 11906362 8156756 2524372 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.193621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 42.9520133375 7624871 17522070 18289764
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 42.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 42.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 42.958291058 7440962 18692083 6482804 18289764 18648102 9022650 6679447 1440618 16192314 9653073 11289319 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 42.9517562736 19085960 11834606 12153990 19370779 17906064 12594235 16081117 11421492 10915739 16485898 18713872 16393943 14725611 11529661 16781746 12392966 19739265 19164858 11287661 19923254 10663392 15619225 18071297 12540782 15968718 12958197 11461765 14986274 19416960 14550746 16177239 17522070 16109766 11739529 12705907 19420014 11743745 16227642 10774834 2444490
MESH:D056486 Drug-Induced Liver Injury Amiodarone 42.9515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 42.954309450 3786805 17522070 10915739 2869522 3732212 15998439 19336974 16227642 15027814 7440962 7120509 6623471 7179309 19085960 10092053 15968718 6884620 16177239 21278145 11566570 9327722
MESH:D056486 Drug-Induced Liver Injury Chloroform 42.953104120 3732212 7440962 6884620 17522070 2862719 6623471 7120509
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 42.9514998559 17522070
MESH:D056486 Drug-Induced Liver Injury pyrazole 42.9512499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 42.9520420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 42.9517522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 42.9512963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 42.9519641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0221218061 17151854 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 8.0516707586
MESH:D050171 Dyslipidemias Dietary Fats 8.0518367378
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:D004487 Edema Aspirin 9.8417259670
MESH:D004487 Edema pirinixic acid 9.8412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.8411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.326426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.783581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.7812903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.7815547733 15150132 15878914 15547721 16805852 16704527 16510608 15623463 15264214
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3916456712
MESH:D005234 Fatty Liver Amiodarone 44.1814986274
MESH:D005234 Fatty Liver arsenic trioxide 44.1815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 44.1819224547 15959796 16045604 12631006 61145 12795759 16239168 17595544
MESH:D005234 Fatty Liver Clofibrate 44.1819224547
MESH:D005234 Fatty Liver Dietary Fats 44.1818296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 44.1815345470
MESH:D005234 Fatty Liver pirinixic acid 44.1819236843 20131406
MESH:D005234 Fatty Liver Tetracycline 44.1819224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 44.1819224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.828888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D005355 Fibrosis Carbon Tetrachloride 12.9218705752
MESH:D005355 Fibrosis Dietary Fats 12.9218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9516904648
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005909 Glioblastoma Aspirin 3.7512870263
MESH:D006013 Glycogen Storage Disease Type VI marker/mechanism
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006261 Headache Aspirin 4.6315240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2817276928 15929193 18665440
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 19.8918590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 19.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 19.8919110552 19900420
MESH:D006505 Hepatitis Thioacetamide 19.8916456712
MESH:D006529 Hepatomegaly Amiodarone 12.5715265979
MESH:D006529 Hepatomegaly pirinixic acid 12.5719772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.5716120746 12621046 15340226
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.718697196 16959395 15340226 16354765 18606429
MESH:D012001 Hyperacusis Aspirin 5.4315240983
MESH:D006930 Hyperalgesia Acetaminophen 2.4516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.208137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.2021332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6215034207
MESH:D006973 Hypertension Phenylephrine 4.888949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
MESH:D006984 Hypertrophy Phenylephrine 4.2612791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.5517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.558137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Dietary Fats 4.3520412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 6.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.5416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.698074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007674 Kidney Diseases Acetaminophen 2.0212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.8816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.886582329
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8419248655
MESH:D007938 Leukemia arsenic trioxide 2.6715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5112560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6917050201 16467208 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0016891316 11161223 9834237 19035177 15213294 15336539 15622746 11468182 16823087 12018890 19075265 17217047 17712046 16330433 12712474 12679006 17649720 16966277 17869043 19225113 16331271 15748426 16112521 17107899 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0416882451
MESH:D008064 Lipidoses Amiodarone 3.2815342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.0317157831 21278145 11903743 17334410 16239168 11408273 16221502 16943688 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 6.0318296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.999327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.5916638106 13678700 18263696 16248980 17922224 12632512 15931870 17631135 17761835 16027843 18006644 11481614 14620537 15057751 17976157 17766677 15925388 18317297 18395095 17944888 17900296 15893842 15818738 12958196 17698563 15996030 15370692 18418968 14512876 15123356 12389079 15362042 12609069 17640975 12546737 16192424 18420326 14724832 18412020 15876570 12666154 18210741 17823541 16116963 16097048 18705752 18472332 18166357 14748882 12586293 16033810 15673190 14716496 15338365 12649538 17565644 17714472 18339082 18376398 15650968 17708605 17721639 18277467 15730626 18251166 18481824 18395914 12667390 15959796 12632514 18472094 17525996 17869086 18429990 12898905 10355542 14716833 12741479 12445418 12445421 16136751 20821823 16015684 17805973 16011737 18156304 17481882 18205269 18054572 18187930 17557913 18279442 15052691
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.5915334695 16126171 11481614 11682029 10677585 18263696 12085344 17050028 12531686 15158331 18031379 16343077 15288473 17127702 16097051 15474484 12557150 12679928 16511523 15078482 15465738 15095483 16248980 17292413 12175628 17355460 14739098 18032466 12891558 18295389 18615449 17629604 18380797 11172339 15075984 15316131 16489207 18395095 18416461 15288472 16098781 18606216 18458672 15362042 15716488
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 8.6817184895
MESH:D008107 Liver Diseases Acetaminophen 8.6812969438 19014921 16611625 12587719 19460945 16610002 19784758 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6815830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases Thioacetamide 8.6818374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.6216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.6214706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 14.6215313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.857678174
MESH:D008113 Liver Neoplasms arsenic trioxide 12.8514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.8519294768
MESH:D008113 Liver Neoplasms pirinixic acid 12.8516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.8516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.476135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 16.473712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.4720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.4712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.4712151625
MESH:D008133 Long QT Syndrome Amiodarone 7.3817391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 7.3815213294
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.1618516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.1617228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.1919825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1919555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008881 Migraine Disorders Aspirin 7.1015240983
MESH:D008881 Migraine Disorders Valproic Acid 7.1018765137 18803445
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8819549372 15949261 11468182 19417148 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.748888407
MESH:D009181 Mycoses Amiodarone 4.5712754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.7917596541
MESH:D009203 Myocardial Infarction Aspirin 5.4712692751
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7016411023
MESH:D009325 Nausea Aspirin 4.8815240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.2618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.267678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.343581430
MESH:D009369 Neoplasms pirinixic acid 1.8017405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.459884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 10.9010525206
MESH:D009436 Neural Tube Defects Valproic Acid 10.9016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.629802331
MESH:D009765 Obesity Dietary Fats 4.1421332399 19632207 20518802 18674790 17217161 11836018 20132043 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.1420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.4416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.4416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.444026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010003 Osteoarthritis Aspirin 3.867009135
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.3119769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Aspirin 6.086363464 6995502
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4115580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.177296757
MESH:D010235 Paraganglioma arsenic trioxide 3.8619927285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.6820133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.6812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1011026799
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.2111156591
MESH:D020795 Photophobia Aspirin 5.4315240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3811896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.3820603192
MESH:D017096 Prion Diseases Tetracycline 5.0910903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3719131511
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.2111422049 12752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7312832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.143692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8719155313
MESH:D012220 Rhinitis Aspirin 4.1012372130
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6516646077
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 8.5418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.5418551238
MESH:D012640 Seizures Valproic Acid 8.5414763951 15475178 3137016 17978042 11044598 16876388 1511512 11738929
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012852 Sinusitis Phenylephrine 4.387327846
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.9412269725
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.078532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2112833885
MESH:D013272 Stomach Diseases Omeprazole 4.2918545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5617007042
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5612958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 6.6318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.6318237397 15991576 16755016 11906479 10750652 17977527
MESH:D020521 Stroke Aspirin 4.1216403987
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D013733 Testicular Diseases pyrazole 4.496499806
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4720133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Aspirin 8.2917672075
MESH:D013927 Thrombosis Ethinyl Estradiol 8.2915669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.631399818 7505956 3712494 6587162 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.6319014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.6315710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5419584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 9.1817467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 9.1815213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.8116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.8116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.818074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.8112973940 12845720 11780464 20435036
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.9010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.9010091137
MESH:D014581 Urticaria Acetaminophen 7.9110982225
MESH:D014581 Urticaria Aspirin 7.9120485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Dietary Fats 3.4716723640
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
REACT:474 Metabolism of carbohydrates
KEGG:00500 Starch and sucrose metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
DB00131 - Adenosine monophosphate Dietary supplement;Micronutrient
DB01696 - 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione Antioxidants
DB02089 - CP-526423
DB02320 - 1-N-Acetyl-Beta-D-Glucosamine
DB02379 - Beta-D-Glucose Sweetening Agents
DB03288 - 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide
DB03684 - 2-Methyl-2,4-Pentanediol
DB03744 - Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate
DB04522 - Phosphonoserine
DB07315 - 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide
DB07395 - 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid
DB07396 - 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid
DB07968 - N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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