Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in decreased expression of MLL3 mRNA | decreases expression | 20406850
|
D000082 |
Acetaminophen |
Acetaminophen affects the expression of MLL3 mRNA | affects expression | 17562736
|
D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of MLL3 mRNA | decreases expression | 20106945
|
D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MLL3 mRNA | decreases expression | 19150397
|
D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin results in increased expression of MLL3 mRNA | increases expression | 20055451
|
D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin results in increased expression of MLL3 mRNA | increases expression | 19684285
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.38 | 15322242 11752688 14514962 |
MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.05 | 20127859 20464547 |
MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.84 | 6695378 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
3.92 | 16835633 |
MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.29 | 11748828 |
MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.45 | 10982225 |
MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.56 | 19183758 |
MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
3.42 | 12125929 |
MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.40 | 15340226 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.97 | 15746008 |
MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.86 | 20146248 17474063 |
MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.86 | 20435547 |
MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
3.09 | 16835633 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.95 | 16705839 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.95 | 3084413 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.54 | 16120746 18670907 18850075 |
MESH:D002386 |
Cataract |
|
Acetaminophen |
2.77 | 10977129 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
7.44 | 6135515 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.44 | 20889678 |
MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.49 | 16835633 |
MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.22 | 16354765 12621046 15668235 15340226 8697196 |
MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.38 | 17141729 14669216 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.27 | 15322242 10048152 20055451 |
MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.50 | 18551238 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.73 | 17107852 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
6.62 | 18551238 21346803 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.62 | 12958197 12594235 14986274 17906064 16081117 19164858 19739265 10663392 15968718 19370779 14725611 18713872 11834606 2444490 16227642 11739529 16781746 14550746 16109766 12392966 19416960 19923254 10774834 19420014 11461765 11743745 18071297 12540782 17522070 16393943 19085960 16485898 11421492 17562736 16177239 11287661 12705907 10915739 15619225 11529661 12153990 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
6.62 | 20420201 |
MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.71 | 19426721 |
MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
3.02 | 11462148 |
MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
2.74 | 11000095 12711302 |
MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.51 | 18230668 15322242 16714409 |
MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.37 | 9294722 10568697 |
MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.59 | 20426865 |
MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.59 | 16530937 |
MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.27 | 11564622 |
MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.94 | 11858732 |
MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.43 | 20067830 |
MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.29 | 16983495 |
MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
5.21 | 10696789 |
MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
6.99 | 20471113 |
MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
6.99 | 11294989 10048152 |
MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.71 | 11000095 |
MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
3.37 | 15340226 12621046 16120746 |
MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.66 | 16959395 15340226 8697196 18606429 16354765 |
MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.99 | 16870215 |
MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
2.01 | 18670907 18850075 |
MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
2.01 | 12200463 12878042 |
MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.71 | 16580747 |
MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.38 | 12587719 15629191 |
MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.28 | 16705839 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
1.25 | 12878042 |
MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.69 | 12969438 19784758 19014921 16610002 19460945 12587719 11587558 16611625 |
MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.58 | 17185352 16871587 |
MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
8.01 | 7678174 |
MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
8.01 | 21137059 20195826 |
MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
8.01 | 16984957 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
6.42 | 2876784 2876786 6135515 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
6.42 | 12151625 |
MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
2.26 | 6695378 18569708 18520028 18816296 20135361 20464547 20869020 17053015 20064080 |
MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
2.26 | 19555203 11884234 |
MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.05 | 19513568 |
MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.46 | 16381670 |
MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.31 | 12213967 |
MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.40 | 7678174 18551238 |
MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.31 | 11141357 |
MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.65 | 14600291 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.18 | 18514411 |
MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.78 | 16049721 |
MESH:D010146 |
Pain |
|
Acetaminophen |
2.69 | 16870215 |
MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.86 | 12520081 |
MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
4.00 | 18163543 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
3.73 | 11896295 11222880 11118676 11399792 |
MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.91 | 17292933 |
MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.28 | 18990726 |
MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.76 | 18551238 |
MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
5.95 | 19755658 10029692 |
MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
5.95 | 16192470 |
MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 2093021 20155912 |
MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.51 | 12697716 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.35 | 16049721 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
5.35 | 17053015 |
MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.86 | 10091137 |
MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.38 | 10982225 |
MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
5.21 | 12125929 |
MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.86 | 15886252 |