AutismKB 2.0

Annotation Detail for QDPR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:QDPR ( DHPR,FLJ42391,PKU2,SDR33C1 )
Gene Full Name: quinoid dihydropteridine reductase
Band: 4p15.32
Quick LinksEntrez ID:5860; OMIM: 612676; Uniprot ID:DHPR_HUMAN; ENSEMBL ID: ENSG00000151552; HGNC ID: 9752
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PHENYLALANINE-DEG1-PWYphenylalanine degradation I (aerobic)
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00790Folate biosynthesis
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00167Phenylketonuria
Inherited disorders of amino acid metabolism
Genetic disorders
No data
No data
No data
Desease Name
Hyperphenylalaninemia, BH4-deficient, C
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of QDPR mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of QDPR mRNAaffects expression 21346803
C000188 alachlor alachlor results in increased expression of QDPR mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of QDPR mRNAaffects expression 16483693
D002995 Clofibric Acid Clofibric Acid affects the expression of QDPR mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of QDPR mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of QDPR mRNAdecreases expression 11323195
D005419 Flavonoids Flavonoids results in decreased expression of QDPR mRNAdecreases expression 18035473
C056933 fumonisin B1 fumonisin B1 results in decreased expression of QDPR mRNAdecreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of QDPR mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9019052882 19061943 17620307 16434500 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000382 Agricultural Workers' Diseases alachlor 4.8911874814 14769641
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7017428255 16540662 3581430 10737359 20727157 19107877 17055752 18691550 17978847 17162532 19539802 20007298 20935162 19208518 18210153 18978308 17138121 19418558 19171122 16569478 18785209 18494052 17173139 11831363 19335982 19919837 17761372 19822196 16878318 18665156 19394651 20524982 10672840 16935385 18788625 20101231 16807293 16698587 3084413 21159647 19052882 20432363 16502159 20214788 20514400 16681979 16328049 16830150 20084675 18056438 19701751 19383236 19519916 18971187 18393292 20512989 16288022 16779866 18506893
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.836135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8321159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.408428444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.4119107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 9.4116221962
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.0821071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 14.0819236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly fumonisin B1 9.5016221962
MESH:D006529 Hepatomegaly pirinixic acid 9.5016221962 18467677 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
OMIM:261630 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C marker/mechanism
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007248 Infertility, Male alachlor 4.2512948887 17049205 16466525
MESH:D007249 Inflammation Diethylnitrosamine 5.4618785209
MESH:D007249 Inflammation Flavonoids 5.4617296493
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007938 Leukemia alachlor 4.0914769641
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118665156 18522880 20032147 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.207678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.2017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2018977376 20137499 20434301 12112319 15175105 10737359 19551842 9163691 19642983 20405173 18648771 20492335 21167192 19812893 19090486 19833225 21071580 19690152 2862719 20452335 20118626 19294768 20583210 12771043 19254457 18644402 19073162 19256749 2422723 18754104 18978307 19638242 19850985 19499222 20501860 19426721 19996281 21047994 20101389 21278145 19427195 19255062 16942905 15885732
MESH:D008113 Liver Neoplasms pirinixic acid 11.2016377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.262876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2616842330 18775883 21159647 17942915 18253720 18093689 17854601 19539802 9362446 18079962 19519916 16267830 18282651 19009564 2563599 3124819 17174075 18544905 18164116 19126423 19004024 18308698
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 6695378 21163286
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009101 Multiple Myeloma alachlor 4.4014769641
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009669 Nose Neoplasms alachlor 5.0611127290 15580706 16698726 16178123 14563481
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.462563599
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012135 Respiratory Sounds alachlor 5.1611874814
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms alachlor 8.078812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.077505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00790 Folate biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34094
    • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    PA450931l-phenylalanine
    PA451822l-tyrosine
    PA161990676tetrahydrobiopterin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03814 - 2-(N-Morpholino)-Ethanesulfonic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved