AutismKB 2.0

Annotation Detail for RAB3A


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Basic Information Top
Gene Symbol:RAB3A ( - )
Gene Full Name: RAB3A, member RAS oncogene family
Band: 19p13.11
Quick LinksEntrez ID:5864; OMIM: 179490; Uniprot ID:RAB3A_HUMAN; ENSEMBL ID: ENSG00000105649; HGNC ID: 9777
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P05734Synaptic vesicle trafficking
Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2001Mental retardation
2124Autistic disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAB3A mRNAaffects expression 16483693
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of RAB3A geneincreases mutagenesis 16724327
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB3A mRNAaffects cotreatment|increases expression 17183730
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB3A protein]affects binding|increases reaction 15099020
D010126 Ozone Ozone results in decreased expression of RAB3A mRNAdecreases expression 16330353
D012402 Rotenone Rotenone promotes the reaction [SNCA protein mutant form binds to RAB3A protein]affects binding|increases reaction 15099020
C017947 sodium arsenite sodium arsenite results in increased expression of RAB3A mRNAincreases expression 12016162
D024505 Tocopherols Tocopherols results in increased expression of RAB3A mRNAincreases expression 17654050
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB3A mRNAaffects cotreatment|increases expression 17183730
D015032 Zinc [MT3 protein binds to RAB3A protein] which results in decreased susceptibility to Zincaffects binding|decreases response to substance 15039103
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000169 Acrodermatitis Zinc 5.6417202136 16889938 17190629
MESH:D000236 Adenoma Ethylnitrosourea 3.816695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000544 Alzheimer Disease Ozone 4.5715513908
MESH:D000544 Alzheimer Disease Zinc 4.5716580781 16325427 17119284 16410023
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000755 Anemia, Sickle Cell Zinc 5.1016916123
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 5.3316373670 17854713
MESH:D001249 Asthma Zinc 5.3317085522
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 16609825 18985861 18775368 15238991 17507914 19460635 18316065 19232924 17688650 18396377 18177632 18558336 17157402 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001930 Brain Injuries Zinc 4.9017109824
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4515144691 16357521 16436596 16651633 18412241
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8116777450 15516495 18315731 18417511 14754758 19059883 17626835
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9915276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.0616543248
MESH:D002318 Cardiovascular Diseases Zinc 3.7716936243
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.4816003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4820056578 19524636
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.958888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Zinc 2.9519302082
MESH:D003920 Diabetes Mellitus Zinc 4.3616479319
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Zinc 2.8916543248
MESH:D005234 Fatty Liver Valproic Acid 3.4719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005756 Gastritis Zinc 5.0617241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9416436596
MESH:D005910 Glioma Ethylnitrosourea 3.5518412241 16651633 16357521
MESH:D006130 Growth Disorders Zinc 4.0717217573
MESH:D006333 Heart Failure Zinc 3.7117162251
MESH:D006335 Heart Injuries Zinc 6.0317074742
MESH:D016481 Helicobacter Infections Zinc 4.7217241300
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9017276780
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007511 Ischemia Zinc 4.8516584753
MESH:D007674 Kidney Diseases sodium arsenite 6.6820008137
MESH:D007674 Kidney Diseases Zinc 6.6816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5916518626
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.0717379185
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008113 Liver Neoplasms sodium arsenite 2.4215276417 16712894
MESH:D008171 Lung Diseases Ozone 7.8919066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.8919095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.7116271038 16019985 17703301 6695378
MESH:D008175 Lung Neoplasms Ozone 3.717614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 3.7117306315 19931552 16712894 15276417 17077188
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.9818041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 10.9817927505
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.9812773700
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D008654 Mesothelioma Tocopherols 4.1615878867
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009369 Neoplasms sodium arsenite 2.5711559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 10.1016707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.1020056578
MESH:D009410 Nerve Degeneration Rotenone 4.0117356569 18619942 15790535
MESH:D009436 Neural Tube Defects sodium arsenite 7.7012854658
MESH:D009436 Neural Tube Defects Valproic Acid 7.708888407 16359493
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516651423 17160924 16003739
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.5312349958
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.3516725203
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4817306315 15276417
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.3716140633 15451049 11181820
MESH:D010300 Parkinson Disease Rotenone 6.3716140633 18619942 18191903 15451049 19114014 11445065 19232380 11535288 16412576
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 10.4512349958
MESH:D020734 Parkinsonian Disorders Rotenone 10.4515927086 18197244 15795934 15574749
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 4.6318007984 18381685 18929643
MESH:D011225 Pre-Eclampsia Zinc 4.3117114810
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8116039940
MESH:D011471 Prostatic Neoplasms Tocopherols 2.8112504091
MESH:D011471 Prostatic Neoplasms Zinc 2.8116700911 16606632 16517595 12429649
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D012162 Retinal Degeneration Zinc 4.2516584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.851511512 15475178 11044598 16876388 3137016 17978042 14763951 11738929
MESH:D012878 Skin Neoplasms sodium arsenite 2.7719524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 9.9912854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D014062 Tongue Neoplasms Zinc 4.5616543248
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5616452187 16712894 11723127 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34132
    • No data
    No data
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA449396dopamine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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