AutismKB 2.0

Annotation Detail for RAB13


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Basic Information Top
Gene Symbol:RAB13 ( - )
Gene Full Name: RAB13, member RAS oncogene family
Band: 1q21.3
Quick LinksEntrez ID:5872; OMIM: 602672; Uniprot ID:RAB13_HUMAN; ENSEMBL ID: ENSG00000143545; HGNC ID: 9762
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RAB13 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RAB13 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAB13 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RAB13 mRNAincreases expression 20458559
D001374 Azacitidine Azacitidine results in decreased methylation of RAB13 promoterdecreases methylation 19194470
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of RAB13 mRNAincreases expression 17032414
C014347 decitabine decitabine results in decreased methylation of RAB13 promoterdecreases methylation 19194470
C014347 decitabine decitabine results in increased expression of RAB13 mRNAincreases expression 19194470
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RAB13 mRNAincreases expression 17032414
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB13 mRNAaffects cotreatment|increases expression 17183730
C029424 hydrazine hydrazine results in decreased expression of RAB13 mRNAdecreases expression 15282401
D019772 Topotecan RAB13 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB13 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7711798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.7716033868
MESH:D000236 Adenoma Dimethylnitrosamine 3.6119555203
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D001321 Autistic Disorder Valproic Acid 2.0018316065 19460635 17688650 20603192 18177632 18396377 16609825 18985861 18775368 15238991 18940202 17507914 17157402 19232924 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D001943 Breast Neoplasms decitabine 2.5619208741 18320071
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216227642 16011737 15721981 16124888 15673190 16050911 15700767 16097048 18705752 3786805 10355542 16192424
MESH:D002277 Carcinoma Dimethylnitrosamine 4.1119555203
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7115553829 11135700 14691202 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7118788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1019215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 5.1016033868
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6220501625
MESH:D015179 Colorectal Neoplasms Azacitidine 3.6219934284
MESH:D015179 Colorectal Neoplasms decitabine 3.6218981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7310525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7316575769 8888407 17688650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.376884620 2869522 11566570 19336974 15027814 19085960 10092053 15968718 21278145 4309450 3732212 7440962 6623471 7120509 7179309 3786805 10915739 9327722 15998439 16177239 17522070 16227642
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 12.378172417
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.3719641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.093922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.687562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8512903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.8517016578
MESH:D005234 Fatty Liver arsenic trioxide 13.8315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.8317595544 16045604 16239168 61145 12631006 19224547 15959796 12795759
MESH:D005234 Fatty Liver Valproic Acid 13.8314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007938 Leukemia arsenic trioxide 10.9315070760
MESH:D007938 Leukemia Azacitidine 10.9319148494
MESH:D007938 Leukemia decitabine 10.9319235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 16.7819077051
MESH:D007951 Leukemia, Myeloid Azacitidine 16.7819077051
MESH:D007951 Leukemia, Myeloid decitabine 16.7819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.9820471514 19850784 16467208 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.9818720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.9819010910 18460780 19387464 17679729 18704418 18206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.9816294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.3119299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2817107899 19075265 11468182 16823087 11161223 12679006 16330433 12712474 19642359 16966277 12018890 16891316 16112521 17649720 15748426 15213294 15336539 9834237 16331271 17712046 15622746 17869043 17217047 19225113 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8617174718 17334410 16221502 16943688 11408273 21278145 17157831 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7615650968 18472094 10355542 12445418 16116963 17481882 17557913 17922224 18156304 17823541 15876570 12666154 18395914 15370692 18418968 14512876 18339082 15730626 18317297 14716496 12586293 12649538 12445421 18210741 18166357 18420326 15996030 15673190 17721639 17698563 17640975 12609069 18705752 16248980 17944888 17869086 12667390 16011737 18205269 15925388 18279442 14620537 12632512 14748882 15057751 18263696 17631135 18472332 20821823 18006644 17525996 17976157 18376398 15818738 12958196 12632514 17766677 17761835 15362042 16638106 12546737 14716833 12898905 18395095 17714472 18054572 17565644 15931870 11481614 16136751 15123356 15052691 16027843 16097048 13678700 15338365 15893842 17805973 18429990 18277467 18251166 17900296 16192424 16033810 18412020 15959796 12741479 16015684 18187930 17708605 18481824 12389079 14724832
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 2.7618567088 16009107 16544323 15479170 17432682 15369754 15763062 17465448 15298665 15571005 15067225 17198567 17348192 15723089 14659978 15577212 15733078 15383259 18672772 17724770 15339415 16169303 18095165 14726149 17881167 16570917 15086199 14643895 15366600 17203207 15842777 15591649 16042886 15099470 15798949 17201889 15864749 18239293 16270385 16603200 17640959 17719030 15942678 16627068 15081153 15793283 18364076 15744066 15138612 14568256 18637143 18629640 17036385 15504291 15161499 17666798 12918455 12925901 15492853 17196135 18210741 14709902 18371158 17534399 18237412
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016964402 15830285 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1914706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 10.1917457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.077678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0719294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 11.073113478 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.736135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.7320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.7315603536 1848544 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7419825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 3.7421224363
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.7411884234 19555203 16061637
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009006 Monosomy Azacitidine 6.2619299654
MESH:D009101 Multiple Myeloma arsenic trioxide 12.7119417148 14977855 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma Azacitidine 12.7118443271 19549372
MESH:D009101 Multiple Myeloma decitabine 12.7118172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 18.1116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Azacitidine 18.1118720364 19805378 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes decitabine 18.1119010910 16882708 18608210 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 18.1117596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms decitabine 2.7619470736 19116145 17925555
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5610525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.568888407 16359493
MESH:D009447 Neuroblastoma Topotecan 3.9015176712
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 5.0919331143 19259094
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5215580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.5219294695
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9820603192
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.5819131511
MESH:D011471 Prostatic Neoplasms Azacitidine 3.5818324645
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D012208 Rhabdomyosarcoma decitabine 11.3719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.3719155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2518551238
MESH:D012640 Seizures Valproic Acid 10.251511512 11738929 11044598 17978042 14763951 15475178 3137016 16876388
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.4412587719
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5517007042
MESH:D013274 Stomach Neoplasms decitabine 3.5519037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.5516033868
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6019014326
MESH:D013964 Thyroid Neoplasms decitabine 7.6017967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2716049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.2712845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.2717616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
Pathway ID Pathway Name
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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