Gene Symbol:	RAB27A ( GS2,HsT18676,MGC117246,RAB27,RAM )
Gene Full Name:	RAB27A, member RAS oncogene family
Band:	15q21.3
Quick Links	Entrez ID:5873; OMIM: 603868; Uniprot ID:RB27A_HUMAN; ENSEMBL ID: ENSG00000069974; HGNC ID: 9766
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
	Immune system diseases
	Primary immunodeficiency
H00101	Other phagocyte defects

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C103303	alitretinoin	alitretinoin results in decreased expression of RAB27A mRNA	decreases expression	16449964
C103303	alitretinoin	RAB27A gene mutant form results in decreased susceptibility to alitretinoin	decreases response to substance	16449964
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RAB27A mRNA	affects expression	16483693
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of RAB27A mRNA	increases expression	15336504
D016572	Cyclosporine	Cyclosporine results in increased expression of RAB27A mRNA	increases expression	20106945
C004648	testosterone enanthate	testosterone enanthate affects the expression of RAB27A mRNA	affects expression	17440010
C025643	vinclozolin	vinclozolin affects the expression of RAB27A mRNA	affects expression	19015723

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000138	Acidosis		Ammonium Chloride	4.02	18287403
MESH:D001008	Anxiety Disorders		vinclozolin	3.89	19015723
MESH:D001943	Breast Neoplasms		alitretinoin	3.08	16344269
MESH:D002471	Cell Transformation, Neoplastic		Cyclosporine	2.73	12371664
MESH:D002779	Cholestasis		Cyclosporine	3.14	19486331
MESH:D003456	Cryptorchidism		vinclozolin	4.72	14966744
MESH:D005234	Fatty Liver		Cyclosporine	3.18	19224547
MESH:D005355	Fibrosis		Cyclosporine	3.56	12639820 12168785
MESH:D030342	Genetic Diseases, Inborn		vinclozolin	5.40	16973722
MESH:D005832	Genital Diseases, Male		vinclozolin	5.82	16417039
MESH:D005885	Gingival Hyperplasia		Cyclosporine	4.68	8708960
OMIM:607624	GRISCELLI SYNDROME, TYPE 2	marker/mechanism
MESH:D006457	Hemoglobinuria, Paroxysmal		Cyclosporine	4.88	15720958
MESH:D019247	HIV Wasting Syndrome		testosterone enanthate	6.27	17440010
MESH:D006973	Hypertension		Cyclosporine	2.19	10903974
MESH:D007248	Infertility, Male		vinclozolin	3.24	16467254
MESH:D007638	Keratoconjunctivitis Sicca		Cyclosporine	4.96	15604871
MESH:D017492	Keratosis, Seborrheic		alitretinoin	6.10	16144296
MESH:D007674	Kidney Diseases		Cyclosporine	2.50	18776723 10903974 8314463
MESH:D007680	Kidney Neoplasms		Cyclosporine	3.00	12371664
MESH:D007984	Leydig Cell Tumor		vinclozolin	5.19	16417039
MESH:D008175	Lung Neoplasms		alitretinoin	2.65	16413115
MESH:D008664	Metal Metabolism, Inborn Errors		Cyclosporine	5.31	16801185
MESH:D009369	Neoplasms		alitretinoin	3.38	16946489
MESH:D009402	Nephrosis, Lipoid		Cyclosporine	4.96	17954296
MESH:D009404	Nephrotic Syndrome		Cyclosporine	3.57	19348381 18481113
MESH:D017499	Porokeratosis		alitretinoin	6.52	16144296
MESH:D011230	Precancerous Conditions		Cyclosporine	3.51	12371664
MESH:D011297	Prenatal Exposure Delayed Effects		vinclozolin	4.36	18220299 18042343 19015723
MESH:D011469	Prostatic Diseases		vinclozolin	5.40	18220299
MESH:D011472	Prostatitis		vinclozolin	5.40	18629315
MESH:D011565	Psoriasis		Cyclosporine	2.31	16882103
MESH:D012878	Skin Neoplasms		tert-Butylhydroperoxide	2.81	8532709
MESH:D014605	Uveitis		Cyclosporine	4.50	1336536
MESH:D014985	Xerophthalmia		Cyclosporine	4.96	17120751

AutismKB 2.0

Annotation Detail for RAB27A

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics