AutismKB 2.0

Annotation Detail for RABGGTA


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Basic Information Top
Gene Symbol:RABGGTA ( PTAR3 )
Gene Full Name: Rab geranylgeranyltransferase, alpha subunit
Band: 14q11.2
Quick LinksEntrez ID:5875; OMIM: 601905; Uniprot ID:PGTA_HUMAN; ENSEMBL ID: ENSG00000100949; HGNC ID: 9795
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200006Signaling events mediated by PRL
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RABGGTA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RABGGTA mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of RABGGTA mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RABGGTA mRNAaffects expression 16483693
D001241 Aspirin Aspirin results in increased expression of RABGGTA mRNAincreases expression 11906190
D014812 Vitamin K Vitamin K affects the expression of RABGGTA mRNAaffects expression 16844298
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.417525203
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9712372130 20485159
MESH:D001932 Brain Neoplasms Aspirin 4.7215481559
MESH:D001943 Breast Neoplasms Aspirin 3.1915161893
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 5.0916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 5.0916705839
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 5.0916328049
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7914694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D003110 Colonic Neoplasms Aspirin 3.0212411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.7721346803
MESH:D004487 Edema Aspirin 4.2117259670
MESH:D005909 Glioblastoma Aspirin 4.1412870263
MESH:D006261 Headache Aspirin 5.4815240983
MESH:D012001 Hyperacusis Aspirin 6.2815240983
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 6135515 2876786
MESH:D008881 Migraine Disorders Aspirin 4.2815240983
MESH:D009203 Myocardial Infarction Aspirin 3.6612692751
MESH:D009325 Nausea Aspirin 5.7315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.9912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.9916049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.9914694615
MESH:D010003 Osteoarthritis Aspirin 4.237009135
MESH:D010146 Pain Aspirin 4.116995502 6363464
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.0011156591
MESH:D020795 Photophobia Aspirin 6.2815240983
MESH:D012220 Rhinitis Aspirin 4.6812372130
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6812269725
MESH:D020521 Stroke Aspirin 4.6316403987
MESH:D013927 Thrombosis Aspirin 4.8017672075
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Aspirin 4.7920485159 10982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04464 - N-Formylmethionine
DB07752 - FARNESYL
DB07780 - FARNESYL DIPHOSPHATE
DB07841 - GERANYLGERANYL DIPHOSPHATE
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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