AutismKB 2.0

Annotation Detail for RAC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAC1 ( MGC111543,TC-25,p21-Rac1 )
Gene Full Name: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Band: 7p22.1
Quick LinksEntrez ID:5879; OMIM: 602048; Uniprot ID:RAC1_HUMAN; ENSEMBL ID: ENSG00000136238; HGNC ID: 9801
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04010MAPK signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04145Phagosome
hsa05416Viral myocarditis
hsa04310Wnt signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04620Toll-like receptor signaling pathway
hsa04972Pancreatic secretion
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Axon guidance
Hemostasis
Signaling by Rho GTPases
Signaling in Immune system
HIV Infection
Pathway IDPathway Name
200035S1P3 pathway
200181S1P2 pathway
200185EPHA2 forward signaling
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200178Paxillin-independent events mediated by a4b1 and a4b7
200004Endothelins
200005BCR signaling pathway
200006Signaling events mediated by PRL
200128Neurotrophic factor-mediated Trk receptor signaling
200132Nephrin/Neph1 signaling in the kidney podocyte
200016Noncanonical Wnt signaling pathway
200014p38 MAPK signaling pathway
200079Arf6 downstream pathway
200127PDGFR-beta signaling pathway
200125E-cadherin signaling in keratinocytes
200124IL6-mediated signaling events
200080mTOR signaling pathway
200069Thromboxane A2 receptor signaling
200066Angiopoietin receptor Tie2-mediated signaling
200099IL2 signaling events mediated by PI3K
200098Class I PI3K signaling events
200173Ephrin B reverse signaling
200071S1P1 pathway
200074Netrin-mediated signaling
200180N-cadherin signaling events
200167Arf1 pathway
200165Regulation of RAC1 activity
200162a6b1 and a6b4 Integrin signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200011LPA receptor mediated events
200113ErbB1 downstream signaling
200117Paxillin-dependent events mediated by a4b1
200114Lissencephaly gene (LIS1) in neuronal migration and development
200115Syndecan-4-mediated signaling events
200041EPHB forward signaling
200042Osteopontin-mediated events
200109Integrins in angiogenesis
200103p75(NTR)-mediated signaling
200105E-cadherin signaling in the nascent adherens junction
200192Signaling events mediated by focal adhesion kinase
200190RAC1 signaling pathway
200053Nectin adhesion pathway
200057CDC42 signaling events
200054Regulation of p38-alpha and p38-beta
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P00018EGF receptor signaling pathway
P00010B cell activation
P00008Axon guidance mediated by Slit/Robo
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00007Axon guidance mediated by semaphorins
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500092Signaling by Robo receptor
500094Inactivation of Cdc42 and Rac
500095Activation of Rac
500075SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
500486CD28 dependent Vav1 pathway
500089DCC mediated attractive signaling
500100Signal transduction by L1
500755Nef and signal transduction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1934Cancer
1985Salmonella infection
2001Mental retardation
2118Adenovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RAC1 mRNAaffects expression 21346803
C041525 3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene affects the localization of RAC1 proteinaffects localization 17194732
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of RAC1 mRNAaffects expression 21346803
C068805 4-hydroxycoumarin 4-hydroxycoumarin results in decreased expression of RAC1 proteindecreases expression 18492274
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of RAC1 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAC1 mRNAaffects expression 16483693
C098980 aplidine aplidine results in increased activity of RAC1 proteinincreases activity 18089842
C006632 arsenic trioxide [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of RAC1 mRNAaffects cotreatment|increases expression 18922899
C006632 arsenic trioxide [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of RAC1 proteinaffects cotreatment|increases expression 18922899
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of RAC1 mRNAincreases expression 15056808
C043211 carvedilol carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein]affects localization|decreases reaction 16940222
D002392 Catechin Catechin results in decreased expression of RAC1 mRNAdecreases expression 15465739
C012843 cinnamic aldehyde cinnamic aldehyde results in decreased expression of RAC1 proteindecreases expression 17486422
C488583 Clostridium difficile lethal toxin B Clostridium difficile lethal toxin B results in decreased activity of RAC1 proteindecreases activity 11158304
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RAC1 mRNAincreases expression 17011747
D000431 Ethanol [Ethanol co-treated with sodium arsenite] results in increased localization of RAC1 proteinaffects cotreatment|increases localization 18182400
D000431 Ethanol Ethanol results in increased localization of RAC1 proteinincreases localization 18182400
D005419 Flavonoids Flavonoids results in decreased expression of RAC1 mRNAdecreases expression 15465739
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased activity of RAC1 proteinincreases activity 11960367
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNAincreases activity|increases expression 11960367
D009240 N-Formylmethionine Leucyl-Phenylalanine N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 proteinincreases activity 16621998
D009240 N-Formylmethionine Leucyl-Phenylalanine RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]decreases reaction|increases activity 16621998
D016244 Guanosine 5'-O-(3-Thiotriphosphate) Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D016244 Guanosine 5'-O-(3-Thiotriphosphate) Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D016244 Guanosine 5'-O-(3-Thiotriphosphate) Secobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D016244 Guanosine 5'-O-(3-Thiotriphosphate) Thiamylal inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D006220 Haloperidol Haloperidol results in increased expression of RAC1 mRNAincreases expression 15860345
D008628 Mercury Mercury results in increased expression of RAC1 mRNAincreases expression 16823088
D008723 Methohexital Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of RAC1 mRNAincreases expression 20024957
C052753 nebivolol nebivolol inhibits the reaction [AGT protein results in increased expression of RAC1 protein]decreases reaction|increases expression 16940222
C487513 NSC 23766 NSC 23766 inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]decreases reaction|increases activity 19349368
D052638 Particulate Matter Particulate Matter affects the localization of RAC1 proteinaffects localization 19371610
D052638 Particulate Matter Particulate Matter results in increased expression of RAC1 mRNAincreases expression 19182107
D010424 Pentobarbital Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]decreases reaction|increases activity 19349368
D010656 Phenylephrine Phenylephrine results in increased activity of RAC1 proteinincreases activity 11158304
D010936 Plant Extracts Plant Extracts results in decreased expression of RAC1 mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of RAC1 mRNAdecreases expression 15465739
C487081 PXD101 PXD101 results in decreased expression of RAC1 mRNAdecreases expression 19606018
D017382 Reactive Oxygen Species RAC1 protein results in increased abundance of Reactive Oxygen Speciesincreases abundance 16150460
D017382 Reactive Oxygen Species resveratrol inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species]decreases reaction|increases abundance 16150460
D017382 Reactive Oxygen Species RAC1 protein mutant form inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]decreases reaction|increases abundance 10973919
D017382 Reactive Oxygen Species RAC1 protein promotes the reaction [Reactive Oxygen Species promotes the reaction [TNF protein results in increased expression of CCL2 mRNA]]increases expression|increases reaction 14576080
D017382 Reactive Oxygen Species RAC1 protein promotes the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 10973919
C059514 resveratrol resveratrol inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species]decreases reaction|increases abundance 16150460
C059514 resveratrol resveratrol inhibits the reaction [RAC1 protein results in increased expression of ICAM1 mRNA]decreases reaction|increases expression 16150460
C059514 resveratrol resveratrol affects the localization of RAC1 proteinaffects localization 17194732
D012631 Secobarbital Secobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
C009277 sodium arsenate sodium arsenate results in increased expression of RAC1 mRNAincreases expression 16882884
C017947 sodium arsenite [Ethanol co-treated with sodium arsenite] results in increased localization of RAC1 proteinaffects cotreatment|increases localization 18182400
C017947 sodium arsenite NSC 23766 inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]decreases reaction|increases activity 19349368
C017947 sodium arsenite Pertussis Toxin inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]decreases reaction|increases activity 19349368
C017947 sodium arsenite S1PR1 protein affects the reaction [sodium arsenite results in increased activity of RAC1 protein]affects reaction|increases activity 19349368
C017947 sodium arsenite sodium arsenite results in increased activity of RAC1 proteinincreases activity 19349368
C017947 sodium arsenite sodium arsenite results in increased localization of and results in increased activity of RAC1 proteinincreases activity|increases localization 18182400
C017947 sodium arsenite sodium arsenite results in increased localization of RAC1 proteinincreases localization 18182400
C017947 sodium arsenite RAC1 protein affects the reaction [sodium arsenite results in increased expression of PECAM1 protein]affects reaction|increases expression 19033667
D012965 Sodium Chloride Sodium Chloride results in increased activity of RAC1 proteinincreases activity 15975986
D018038 Sodium Selenite Sodium Selenite results in increased activity of RAC1 proteinincreases activity 12896980
C013690 styrene oxide styrene oxide results in decreased expression of RAC1 proteindecreases expression 17662326
D013395 Sucrose Sucrose results in increased activity of RAC1 proteinincreases activity 15975986
C452601 sulindac derivative IND 12 sulindac derivative IND 12 results in increased activity of RAC1 proteinincreases activity 11912145
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of RAC1 mRNAaffects cotreatment|increases expression 18922899
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of RAC1 proteinaffects cotreatment|increases expression 18922899
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of RAC1 mRNAincreases expression 18922899
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of RAC1 proteinincreases expression 18922899
D013840 Thiamylal Thiamylal inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]decreases reaction|increases activity 15263067
D014212 Tretinoin Tretinoin results in increased activity of RAC1 proteinincreases activity 17130476
C012589 trichostatin A trichostatin A results in decreased expression of RAC1 mRNAdecreases expression 19606018
D014501 Uranium Uranium affects the expression of RAC1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of RAC1 mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin results in increased expression of RAC1 mRNAincreases expression 18629315
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.177525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.1718926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 8.7518287403
MESH:D000138 Acidosis Ethanol 8.7511192467
MESH:D058186 Acute Kidney Injury resveratrol 3.3916538975
MESH:D055371 Acute Lung Injury Particulate Matter 4.7312396868
MESH:D000230 Adenocarcinoma arsenic trioxide 2.1511798837 19825857
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.1510737359
MESH:D000236 Adenoma resveratrol 6.1515688382
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.486705139
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3717306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7915451039 15451040
MESH:D000505 Alopecia Tretinoin 3.2015955085
MESH:D000544 Alzheimer Disease Particulate Matter 6.1015513908
MESH:D000544 Alzheimer Disease Plant Extracts 6.1016962711
MESH:D000544 Alzheimer Disease resveratrol 6.1016162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9915469931
MESH:D000853 Anophthalmos Ethanol 4.3115513904
MESH:D001008 Anxiety Disorders Ethanol 12.6211141031
MESH:D001008 Anxiety Disorders Pentobarbital 12.6211141031 18313124
MESH:D001008 Anxiety Disorders vinclozolin 12.6219015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6717460149
MESH:D001169 Arthritis, Experimental Plant Extracts 10.5014686799
MESH:D001169 Arthritis, Experimental resveratrol 10.5017115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.5016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1316292516
MESH:D001249 Asthma Tretinoin 2.1716456186
MESH:D050197 Atherosclerosis resveratrol 2.9616873680 17967414
MESH:D001321 Autistic Disorder Haloperidol 2.6319368416 18080171
MESH:D001321 Autistic Disorder Mercury 2.6317497416
MESH:D001327 Autoimmune Diseases Mercury 4.3716634805
MESH:D001471 Barrett Esophagus Tretinoin 3.9116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.6316206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.6316197459 16206674
MESH:D001919 Bradycardia Phenylephrine 4.0315306635
MESH:D002545 Brain Ischemia Plant Extracts 8.7516041641
MESH:D002545 Brain Ischemia resveratrol 8.7517600658
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0515324884 17129689
MESH:D001943 Breast Neoplasms resveratrol 2.0517651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tretinoin 2.0516443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0716813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8511589617
MESH:D002056 Burns Ethanol 4.1516374292
MESH:D002057 Burns, Chemical Plant Extracts 4.819625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2816097048 16192424 15700767 18705752 15721981 10355542 15673190 16050911 16124888 3786805 16011737 16227642
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 20.5616705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 20.563084413 6705139 10737359 3581430 17761372
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 20.5611135700 16217749 14691202 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 20.5618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 20.5616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Ethanol 20.5615763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 20.5618834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 20.5616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 20.5616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.561917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0716675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6612490120
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.3516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.3518572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.3518922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.3516096774 16051514
MESH:D006332 Cardiomegaly Ethanol 9.9019332462
MESH:D006332 Cardiomegaly Phenylephrine 9.9011754973 16170337 17124262 17287366 15728586 11179087
MESH:D006332 Cardiomegaly Plant Extracts 9.9017645561
MESH:D009202 Cardiomyopathies carvedilol 4.7715476868
MESH:D002311 Cardiomyopathy, Dilated carvedilol 6.0919477965
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.0910334427
MESH:D002318 Cardiovascular Diseases Particulate Matter 6.7912396868
MESH:D002318 Cardiovascular Diseases resveratrol 6.7915458977
MESH:D002375 Catalepsy Haloperidol 4.3915215559 1977408
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.5414694615
MESH:D002386 Cataract Tretinoin 6.5417460283
MESH:D002471 Cell Transformation, Neoplastic cinnamic aldehyde 9.488243401
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 9.4819716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.4819524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0716129372
MESH:D002822 Choriocarcinoma Tretinoin 4.6316461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.2515894690
MESH:D002971 Cleft Lip Ethanol 3.3015513904
MESH:D002972 Cleft Palate Ethanol 5.3515513904
MESH:D002972 Cleft Palate Tretinoin 5.359407595
MESH:D003092 Colitis resveratrol 7.9516474422
MESH:D003092 Colitis Tretinoin 7.9517035595
MESH:D003110 Colonic Neoplasms cinnamic aldehyde 5.4216343908 17510524
MESH:D003110 Colonic Neoplasms polyphenols 5.4216293270
MESH:D003110 Colonic Neoplasms resveratrol 5.4216338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4820501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.4816550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 3.7215095906
MESH:D003327 Coronary Disease resveratrol 3.4116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.5710525206
MESH:D019465 Craniofacial Abnormalities Ethanol 6.5711198716 15451039 11873399 19302082 15451040 15513904 10194807
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 6.5715736158
MESH:D019465 Craniofacial Abnormalities sodium arsenate 6.5710525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.579224671 17551590 9142499 16925845 9664655 10589399 9125849 9211117 8800419 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.7316002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 9.7314966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5118551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 9.3315213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.3320210726
MESH:D003704 Dementia Haloperidol 4.1211575062
MESH:D017449 Dermatitis, Allergic Contact cinnamic aldehyde 6.2011042091
MESH:D017449 Dermatitis, Allergic Contact Mercury 6.2016823706
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.3416285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3516873680
MESH:D003928 Diabetic Nephropathies Plant Extracts 7.9319706694
MESH:D003928 Diabetic Nephropathies resveratrol 7.9316286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.8421346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.843732212 17522070 19336974 21278145 10092053 7440962 6884620 2869522 16177239 10915739 15027814 15968718 6623471 9327722 15998439 4309450 16227642 7120509 3786805 11566570 7179309 19085960
MESH:D056486 Drug-Induced Liver Injury Ethanol 15.8411566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 15.8419370779
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 15.8418186108
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.8415131321
MESH:D004487 Edema Plant Extracts 9.1412787963
MESH:D004487 Edema resveratrol 9.148985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 9.147812673 11698051 9599246 15177302 8273558 16716910 8113982
MESH:D004489 Edema, Cardiac Tretinoin 3.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5417872969
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.1119294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.1716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.4216804899 15700306
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4216569247
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.1515268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3417923197
MESH:D004827 Epilepsy Plant Extracts 3.4519439326 19700373
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.1812903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.1816704527
MESH:D005124 Eye Abnormalities Tretinoin 3.1816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 15.0815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.0816045604 19224547 12795759 61145 15959796 17595544 12631006 16239168
MESH:D005234 Fatty Liver Ethanol 15.0819236843 16409862 18620774
MESH:D005234 Fatty Liver Plant Extracts 15.0815975614
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1417920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3216002989 16513791 16534752 16611131 15751030
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7815513904 10194807 15451040 16946407
MESH:D005355 Fibrosis Carbon Tetrachloride 7.1418705752
MESH:D005355 Fibrosis Tretinoin 7.1417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7716904648
MESH:D005756 Gastritis Ethanol 4.1715046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7716417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.0916452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.0916452187
MESH:D005909 Glioblastoma Tretinoin 6.2617312396
MESH:D005909 Glioblastoma trichostatin A 6.2618801729
MESH:D018149 Glucose Intolerance sodium arsenate 4.6019446573
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.6114991402 9664655
MESH:D006333 Heart Failure Plant Extracts 3.5418097624
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.796705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.956705139
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1119900420 19110552
MESH:D006561 Herpes Simplex Plant Extracts 8.4010715843
MESH:D006561 Herpes Simplex resveratrol 8.4016876885
MESH:D015658 HIV Infections Plant Extracts 3.4012878215
MESH:D006689 Hodgkin Disease sodium arsenite 2.7312676792
MESH:D019584 Hot Flashes Plant Extracts 4.2214716179 16566672 17454163
MESH:D006930 Hyperalgesia Ethanol 6.6318783367
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0116899240
MESH:D006937 Hypercholesterolemia resveratrol 3.5517188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0616778211
MESH:D020138 Hyperhomocysteinemia Catechin 8.4717292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.4716484555
MESH:D006949 Hyperlipidemias Plant Extracts 8.0215975614 15268973
MESH:D006949 Hyperlipidemias resveratrol 8.0216873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9314722030 12960047
MESH:D006973 Hypertension carvedilol 7.9016640825
MESH:D006973 Hypertension Phenylephrine 7.908949925 12717712
MESH:D006973 Hypertension Sodium Chloride 7.9011507004
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5815338365
MESH:D006984 Hypertrophy Phenylephrine 4.0918502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8517488730
MESH:D007021 Hypospadias Diethylstilbestrol 4.0716002989
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1417600658
MESH:D007246 Infertility Diethylstilbestrol 3.8615036965
MESH:D007248 Infertility, Male sodium arsenite 5.6615346721 12646999
MESH:D007248 Infertility, Male vinclozolin 5.6616467254
MESH:D007249 Inflammation Flavonoids 12.8217296493
MESH:D007249 Inflammation Plant Extracts 12.8216366677 12787963 15997105 19332304
MESH:D007249 Inflammation polyphenols 12.8216366677
MESH:D007249 Inflammation resveratrol 12.8216366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 12.828273558 7562506 7812673 15177302 11698051
MESH:D007251 Influenza, Human resveratrol 4.0216624496
MESH:D007333 Insulin Resistance Sodium Selenite 2.9314714311
MESH:D007410 Intestinal Diseases Tretinoin 3.2617994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.1712628509 12584176 12351151
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.5319381132
MESH:D007569 Jaw Abnormalities Ethanol 8.7815513904
MESH:D007569 Jaw Abnormalities Tretinoin 8.7815992940 17551590
MESH:D007674 Kidney Diseases Mercury 5.4217934191
MESH:D007674 Kidney Diseases sodium arsenite 5.4220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.1416705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 6.1415003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 8.1117184923
MESH:D007859 Learning Disorders Ethanol 8.1115451040
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.509499605
MESH:D007938 Leukemia arsenic trioxide 5.4115070760
MESH:D007938 Leukemia Tretinoin 5.4117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.0414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.9319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.9316932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.5020471514 16467208 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.5019850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.5018206229
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.7411161223 17107899 17869043 16891316 16966277 19642359 17217047 12712474 15622746 16330433 16823087 17712046 17649720 19035177 19225113 15748426 12018890 9834237 12679006 19075265 16331271 11468182 15213294 16112521 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.7416087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.7419035177 15748426 17339181 17294898 17107899 12679006 16140955 17649720 17217047 19225113 16891316 17506722 17712046 17368321 19075265 16331271 9834237 16935935 19642359 17301526 17361223 16766008 16823087 19029980 16788101
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8616882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2116417039
MESH:D017880 Limb Deformities, Congenital Ethanol 7.0517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.059224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.4317334410 17157831 17174718 16943688 16239168 21278145 16221502 11408273 11903743
MESH:D008103 Liver Cirrhosis Ethanol 9.4315289165
MESH:D008103 Liver Cirrhosis Plant Extracts 9.4317157831
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5818295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.3817708605 14620537 17761835 18006644 18395914 15052691 15730626 15959796 15996030 17631135 15338365 16027843 18376398 12632512 12632514 16192424 18472332 17766677 15362042 15876570 10355542 15057751 12898905 18481824 12546737 14512876 17557913 15650968 17805973 18263696 16638106 14716833 15673190 16116963 15123356 17976157 14748882 18418968 17922224 15925388 15818738 18420326 12741479 20821823 18429990 12958196 12586293 17565644 17481882 18705752 17869086 18395095 16248980 12609069 18205269 12649538 18339082 12445418 18472094 15370692 15931870 16011737 18210741 18317297 17714472 16015684 18251166 13678700 16136751 14716496 18412020 12389079 18279442 17525996 17721639 12667390 18277467 17698563 11481614 17944888 18187930 16033810 12445421 17900296 16097048 14724832 12666154 17823541 17640975 18156304 15893842 18166357 18054572
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.3818166357
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 4.3815479170
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.3818397230 16248980
MESH:D008107 Liver Diseases marker/mechanism 17058265
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.8016246199 15720792 17285989 15830285 16964402
MESH:D008107 Liver Diseases Plant Extracts 5.8017034775
MESH:D008107 Liver Diseases polyphenols 5.8016698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1517347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2416899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 18.4516273603 11376686 14678523 10672840 10737359 18001218
MESH:D008113 Liver Neoplasms arsenic trioxide 18.4514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.4519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.4516712894 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 18.4519168119
MESH:D008113 Liver Neoplasms resveratrol 18.4520405173 19321006 19812893 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 18.4516712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 11.501399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.5020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.5015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental styrene oxide 11.5012562636
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9515213294
MESH:D008171 Lung Diseases sodium arsenite 2.8219095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 5.7711376686
MESH:D008175 Lung Neoplasms arsenic trioxide 5.7711798837 19825857
MESH:D008175 Lung Neoplasms Plant Extracts 5.7720869020
MESH:D008175 Lung Neoplasms sodium arsenite 5.7717306315 19931552 17077188 16712894 15276417
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.7711807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.1015700306
MESH:D016393 Lymphoma, B-Cell resveratrol 8.6917088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 8.6914737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4514749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9916002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.3011606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 5.308985016
MESH:D008527 Medulloblastoma Tretinoin 2.5617453147
MESH:D008545 Melanoma aplidine 10.9818089842
MESH:D008545 Melanoma Reactive Oxygen Species 10.9817992120
MESH:D008545 Melanoma resveratrol 10.9817992120
MESH:D008545 Melanoma sodium arsenite 10.9816487513 19082730
MESH:D008545 Melanoma Tretinoin 10.9816752155
MESH:D008545 Melanoma trichostatin A 10.9816505122
MESH:D008546 Melanoma, Experimental 4-hydroxycoumarin 6.0518492274
MESH:D008569 Memory Disorders Ethanol 3.7018411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9216940565
MESH:D001523 Mental Disorders Haloperidol 3.5116856516
MESH:D008659 Metabolic Diseases resveratrol 3.9117112576
MESH:D009101 Multiple Myeloma arsenic trioxide 10.0615949261 19417148 14977855 11468182 19549372
MESH:D009101 Multiple Myeloma resveratrol 10.0616490592 17935668 16267019 17164350 17049120 14749477
MESH:D009101 Multiple Myeloma trichostatin A 10.0618172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3517962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3918186108
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.3416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.3417596541
MESH:D009203 Myocardial Infarction resveratrol 2.8016456233 16317513 16525036 17125593 17188708 17015251
MESH:D017202 Myocardial Ischemia resveratrol 3.5917125593 17015251
MESH:D009205 Myocarditis Particulate Matter 10.7012563109
MESH:D009205 Myocarditis resveratrol 10.7017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4716624393
MESH:D009362 Neoplasm Metastasis 4-hydroxycoumarin 4.8618492274
MESH:D009369 Neoplasms Diethylstilbestrol 6.7315313581
MESH:D009369 Neoplasms sodium arsenite 6.7311559025
MESH:D009369 Neoplasms Tretinoin 6.7316946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 7.568985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.5620056578
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.2211399458
MESH:D009421 Nervous System Malformations Tretinoin 8.229125849
MESH:D009436 Neural Tube Defects arsenic trioxide 14.4910525206
MESH:D009436 Neural Tube Defects sodium arsenate 14.4918186108 10525206 19446573 11749123
MESH:D009436 Neural Tube Defects sodium arsenite 14.4912854658
MESH:D009436 Neural Tube Defects Tretinoin 14.499142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.6817168769
MESH:D019636 Neurodegenerative Diseases resveratrol 3.3917652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9217929310
MESH:D009765 Obesity Plant Extracts 3.0020132043 19056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6412819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 7.6414694615
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7817513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 9.7412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.7415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 9.7416936753
MESH:D010051 Ovarian Neoplasms trichostatin A 9.7419331143
MESH:D010146 Pain Tretinoin 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 17.7315580305
MESH:D010190 Pancreatic Neoplasms Ethanol 17.7312384795
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 17.7315580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 17.7315976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.7315976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 17.7319294695
MESH:D010212 Papilloma Plant Extracts 8.0916517061 15173996
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.098330346 12065085 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.6819927285
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1616977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.4217184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.4216679765
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.4218042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis trichostatin A 4.7417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4218220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0119131511
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0115046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.0117804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 2.0116731767 17675339 17804756 15767336 17636462 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0116039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0118760546
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0119789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.4218629315
MESH:D011507 Proteinuria Tretinoin 3.1316636307
MESH:D011595 Psychomotor Agitation Haloperidol 4.4511575062
MESH:D011618 Psychotic Disorders Haloperidol 3.8711575062
MESH:D011625 Pterygium Tretinoin 4.2716723453
MESH:D011658 Pulmonary Fibrosis Particulate Matter 3.9712475806
MESH:D012021 Reflex, Abnormal Pentobarbital 5.5010930210
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0516325855
MESH:D015427 Reperfusion Injury resveratrol 3.0016314181 15827377 17058453 17520802 16317513
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6216283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4716646077
MESH:D012559 Schizophrenia Haloperidol 2.7319369910 1830565 18513383 20107430
MESH:D012640 Seizures 2,4-dinitrotoluene 14.8518551238
MESH:D012640 Seizures Ethanol 14.859754883
MESH:D012640 Seizures Pentobarbital 14.859754883 10087439
MESH:D012640 Seizures Secobarbital 14.859806000
MESH:D012640 Seizures Thiamylal 14.859046859
MESH:D012852 Sinusitis Phenylephrine 4.197327846
MESH:D012871 Skin Diseases monomethylarsonous acid 3.2317431481
MESH:D012878 Skin Neoplasms Plant Extracts 15.1116517061 15173996
MESH:D012878 Skin Neoplasms resveratrol 15.1115837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 15.1119524636 18572023
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.118985016 18404319 11807781 12065085 8330346
MESH:D012878 Skin Neoplasms Tretinoin 15.1116467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.1816709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3912854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.7217007042
MESH:D013274 Stomach Neoplasms Ethanol 5.7218456281
MESH:D013274 Stomach Neoplasms Sodium Chloride 5.7216646055
MESH:D013274 Stomach Neoplasms styrene oxide 5.7212562636
MESH:D013274 Stomach Neoplasms Tretinoin 5.7217261132
MESH:D013276 Stomach Ulcer Ethanol 6.199211565 11906479 9562338 17918041 16755016 17189318
MESH:D013276 Stomach Ulcer Plant Extracts 6.1918237397 17135157 12787963 15255614 18193104
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0316321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 8.769754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.769754883 11529278
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.2220210726
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 11.5117997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 11.5117997062
MESH:D013964 Thyroid Neoplasms arsenic trioxide 5.8919014326
MESH:D013964 Thyroid Neoplasms Tretinoin 5.8917045167 16026305
MESH:D014062 Tongue Neoplasms resveratrol 8.4116227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.4116051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4515213294
MESH:D014376 Tuberculosis Tretinoin 2.8916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.8916049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 16.8915289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 16.8912845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.8916452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 16.8920375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 16.8916452187 16712894 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8010091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.9516175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 18.9517473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 18.9511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.9516129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.1516690809 15809267
MESH:D014594 Uterine Neoplasms resveratrol 8.1517044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.0816752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9316002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.9117056641
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 8.8518097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.8517488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.8018097624
MESH:D014820 Vitiligo Tretinoin 3.5616761959
MESH:D009396 Wilms Tumor Tretinoin 3.5316287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.8319894650 20213670
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04662 B cell receptor signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05210 Colorectal cancer
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:6185 HIV Infection
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04670 Leukocyte transendothelial migration
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:04972 Pancreatic secretion
KEGG:05200 Pathways in cancer
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
KEGG:05131 Shigellosis
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04620 Toll-like receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:05416 Viral myocarditis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34162
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA448515azathioprine
    PA450379mercaptopurine
    PA448948chloroquine
    PA450191lecithin
    PA448478l-arginine
    PA450635nitric oxide
    PA448976choline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved