AutismKB 2.0

Annotation Detail for RAC2


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Basic Information Top
Gene Symbol:RAC2 ( EN-7,Gx,HSPC022 )
Gene Full Name: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Band: 22q13.1
Quick LinksEntrez ID:5880; OMIM: 602049; Uniprot ID:RAC2_HUMAN; ENSEMBL ID: ENSG00000128340; HGNC ID: 9802
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04010MAPK signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa05416Viral myocarditis
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by GPCR
Axon guidance
Hemostasis
Signaling by Rho GTPases
No data
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P00018EGF receptor signaling pathway
P00010B cell activation
P00008Axon guidance mediated by Slit/Robo
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00007Axon guidance mediated by semaphorins
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00099Leukocyte adhesion deficiency
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1860Brain tumor
Desease Name
IMMUNE
neutrophil immunodeficiency syndrome
No data
Desease Name
Neutrophil immunodeficiency syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RAC2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RAC2 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of RAC2 mRNAaffects expression 18414638
C006632 arsenic trioxide arsenic trioxide results in decreased expression of RAC2 mRNAdecreases expression 19128835
C423222 cotylenin A cotylenin A results in increased expression of RAC2 mRNAincreases expression 16129123
C014347 decitabine decitabine affects the expression of RAC2 mRNAaffects expression 17145863
D009240 N-Formylmethionine Leucyl-Phenylalanine N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 proteinincreases activity 16621998
D009240 N-Formylmethionine Leucyl-Phenylalanine RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11145705
D009240 N-Formylmethionine Leucyl-Phenylalanine RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11145705
D009240 N-Formylmethionine Leucyl-Phenylalanine RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]decreases reaction|increases activity 16621998
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of RAC2 mRNAincreases expression 15458575
D010269 Paraquat Paraquat results in increased expression of RAC2 mRNAincreases expression 15458575
C006253 pirinixic acid pirinixic acid results in decreased expression of RAC2 mRNAdecreases expression 17426115
D018038 Sodium Selenite Sodium Selenite results in increased expression of RAC2 mRNAincreases expression 18175754
D013755 Tetradecanoylphorbol Acetate RAC2 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11145705
D013755 Tetradecanoylphorbol Acetate RAC2 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11145705
D014212 Tretinoin Tretinoin results in increased expression of RAC2 mRNAincreases expression 17218384
D014415 Tunicamycin Tunicamycin results in increased expression of RAC2 mRNAincreases expression 15458575
C025643 vinclozolin vinclozolin affects the expression of RAC2 mRNAaffects expression 19015723
D014750 Vincristine RAC2 protein affects the susceptibility to Vincristineaffects response to substance 19783987
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 5.0111798837 19825857
MESH:D000230 Adenocarcinoma Vincristine 5.0119825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.753712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2417306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7811874814
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D020261 Arsenic Poisoning Arsenic 2.8718414634 12569548 16835338 16251483
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D050197 Atherosclerosis Arsenic 3.2512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0511289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3916197459 16206674
MESH:D001943 Breast Neoplasms decitabine 2.3119208741 18320071
MESH:D001943 Breast Neoplasms Tretinoin 2.3116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5915504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.883084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.8817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8814691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.881917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.997296757
MESH:D002292 Carcinoma, Renal Cell Vincristine 6.9916201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 14.4017687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.4019215824
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.4018922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.4016096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Vincristine 14.406189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0818640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.5915738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.5916936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.3118022660 16973168
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.767505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.8519486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.8519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5820501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5818981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6810525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.688800419 10589399 9211117 9664655 9224671 9125849 9142499 17551590 16925845 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.828156756 11298694 18759878 14531868 2524372 8970840 12868966 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.502952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.227440962 6679447 1440618 8291058 18289764 9653073 16192314 18692083 9022650 11289319 6482804 9328219 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2212392966 11834606 12540782 16081117 11739529 14986274 16393943 15619225 17562736 19420014 2444490 16227642 11529661 19085960 12594235 16109766 10663392 15968718 19923254 17522070 19370779 17906064 11461765 12958197 10915739 10774834 12705907 11287661 14725611 11421492 16485898 16177239 16781746 19739265 18713872 14550746 19164858 19416960 11743745 18071297 12153990
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004487 Edema pirinixic acid 7.0112083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.018273558 16716910 7812673 11698051 9599246 8113982 15177302
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4712903497
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 7.7415073043
MESH:D005234 Fatty Liver pirinixic acid 7.7420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D005355 Fibrosis Tretinoin 3.5317994277
MESH:D005534 Foot Diseases Arsenic 5.596392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D005911 Gliosis Paraquat 5.1911124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006258 Head and Neck Neoplasms decitabine 7.8419215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.909664655 14991402
MESH:D006331 Heart Diseases marker/mechanism 16330681
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0118467677 19772884 16221962 19176532
MESH:D006689 Hodgkin Disease Vincristine 4.6015147373 16794504 17606976 16135485
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4617050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Arsenic 2.879931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 5.5916093927
MESH:D007248 Infertility, Male decitabine 11.3517581917
MESH:D007248 Infertility, Male Paraquat 11.354850670
MESH:D007248 Infertility, Male vinclozolin 11.3516467254
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.0915177302 7562506 8273558 11698051 7812673
MESH:D007333 Insulin Resistance pirinixic acid 7.3216306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.3214714311
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.059022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007642 Keratosis Arsenic 5.0112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.2015629191 12587719
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2816518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.976582329
MESH:D007938 Leukemia arsenic trioxide 10.5115070760
MESH:D007938 Leukemia decitabine 10.5118980019 19235587
MESH:D007938 Leukemia Tretinoin 10.5117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 16.0419077051
MESH:D007951 Leukemia, Myeloid decitabine 16.0417236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 16.0416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1616968895 20471514 16467208 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1618460780 19010910 17679729 18704418 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1619850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 12.7917339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.7916966277 17649720 12018890 11468182 11161223 9834237 16331271 17107899 17869043 12712474 19075265 19642359 15748426 16112521 15336539 16330433 12679006 16891316 15622746 19035177 17217047 15213294 19225113 17712046 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.7912679006 17712046 17217047 19075265 16823087 19035177 17368321 9834237 16766008 17107899 16935935 19642359 19225113 17339181 16891316 16788101 19029980 16140955 17294898 16331271 17361223 17649720 17301526 15748426 17506722
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.209327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.0712587719 12969438 16610002 19784758 19460945 16611625 19014921 11587558
MESH:D008107 Liver Diseases Arsenic 4.0711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 7.4916368122
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4914682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.4916377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.966587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008175 Lung Neoplasms Arsenic 5.0017976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0011798837 19825857
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.0011807781
MESH:D008175 Lung Neoplasms Vincristine 5.0019825857 6189445
MESH:D008223 Lymphoma marker/mechanism 19783987
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.368985016
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma marker/mechanism 17145863
MESH:D008545 Melanoma decitabine 3.4216505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4216752155
MESH:D018328 Melanoma, Amelanotic Vincristine 5.8015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 7.3811468182 14977855 19417148 15949261 19549372
MESH:D009101 Multiple Myeloma decitabine 7.3818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.3516882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 12.3518608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.3517596541
MESH:D009203 Myocardial Infarction pirinixic acid 6.1519151258
MESH:D009203 Myocardial Infarction Vincristine 6.1517284715
MESH:D017202 Myocardial Ischemia Arsenic 3.9815371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.473581430
MESH:D009369 Neoplasms decitabine 8.2719470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 8.2717405874
MESH:D009369 Neoplasms Tretinoin 8.2716946489 16594593
MESH:D009410 Nerve Degeneration Paraquat 3.7216893418
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 17.366679447
MESH:D009436 Neural Tube Defects Arsenic 17.3616620997
MESH:D009436 Neural Tube Defects arsenic trioxide 17.3610525206
MESH:D009436 Neural Tube Defects Tretinoin 17.369142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D017599 Neuroectodermal Tumors Vincristine 5.7312837982
MESH:D020078 Neurogenic Inflammation Arsenic 4.3817056641
OMIM:608203 NEUTROPHIL IMMUNODEFICIENCY SYNDROME marker/mechanism
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.426482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D010051 Ovarian Neoplasms Arsenic 11.3417306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.3416624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 11.3419331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3416936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.3915580305
MESH:D010190 Pancreatic Neoplasms decitabine 12.3919294695
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 12.3915976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.3915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 15.727296757
MESH:D010212 Papilloma Hydrogen Peroxide 15.7212065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 15.7212065085 18922899 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010300 Parkinson Disease Paraquat 2.8115451049 15824117 11445065 11124998 12911755 11181820 16140633 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4416190885
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.016392382 16905509 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D011014 Pneumonia Paraquat 4.4712504350
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.6221297632
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9219015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms Arsenic 2.6516140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6519131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6518760546
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011507 Proteinuria Arsenic 9.3021343184
MESH:D011507 Proteinuria Tretinoin 9.3016636307
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9116324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.9111700416
MESH:D012135 Respiratory Sounds Paraquat 4.0711874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.923692021
MESH:D012162 Retinal Degeneration Paraquat 8.9216458197
MESH:D012208 Rhabdomyosarcoma decitabine 10.9719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.9716283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012871 Skin Diseases Arsenic 2.7519834688 6392382 18709164 17548696 15952646 17050553 16702368 17938729 17453740 16759981 16353154
MESH:D012878 Skin Neoplasms Arsenic 13.6717976673 19538983 17029826 15504454 16251483 17050553
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.6712065085
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.6712065085 11807781 8985016 18404319 8330346
MESH:D012878 Skin Neoplasms Tretinoin 13.6716467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4217007042
MESH:D013274 Stomach Neoplasms decitabine 3.4219037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.4217261132
MESH:D015173 Supratentorial Neoplasms Vincristine 5.8912837982
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.147505956 1399818 6587162 3712494 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 17.1419014326
MESH:D013964 Thyroid Neoplasms decitabine 17.1417967635
MESH:D013964 Thyroid Neoplasms Tretinoin 17.1417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.988074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.9811144890 15987713 19322015 17306315 18640142 17976673 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.9812973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.9817616700 19087683
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms decitabine 12.9317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.9316752155
MESH:D014652 Vascular Diseases Arsenic 4.7517056641
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05210 Colorectal cancer
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
KEGG:04370 VEGF signaling pathway
KEGG:05416 Viral myocarditis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34163
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443421Arrhythmias, Cardiac
    PA445018Cardiomyopathies
    PA443937Drug Toxicity
    PA444845Lymphoma, Non-Hodgkin
    Releated drug ID Related drug Name
    PA448515azathioprine
    PA450379mercaptopurine
    PA449412doxorubicin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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