AutismKB 2.0

Annotation Detail for RAC3


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Basic Information Top
Gene Symbol:RAC3 ( - )
Gene Full Name: ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
Band: 17q25.3
Quick LinksEntrez ID:5881; OMIM: 602050; Uniprot ID:RAC3_HUMAN; ENSEMBL ID: ENSG00000169750; HGNC ID: 9803
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa05416Viral myocarditis
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa04510Focal adhesion
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Signaling by Rho GTPases
No data
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P00018EGF receptor signaling pathway
P00010B cell activation
P00008Axon guidance mediated by Slit/Robo
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00007Axon guidance mediated by semaphorins
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RAC3 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of RAC3 mRNAincreases expression 19774075
C015001 arsenite arsenite results in decreased expression of RAC3 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of RAC3 mRNA]affects reaction|decreases expression 18929588
D004041 Dietary Fats Dietary Fats results in increased expression of RAC3 mRNAincreases expression 18042831
C051890 irinotecan irinotecan metabolite results in increased expression of RAC3 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of RAC3 mRNAincreases expression 15956246
D007529 Isoflavones Isoflavones results in decreased expression of RAC3 mRNAdecreases expression 17374662
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of RAC3 mRNAincreases expression 20024957
C041786 palm oil palm oil results in increased expression of RAC3 mRNAincreases expression 18042831
C059514 resveratrol resveratrol results in decreased expression of RAC3 mRNAdecreases expression 17804521
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.0616538975
MESH:D000236 Adenoma resveratrol 3.4215688382
MESH:D000505 Alopecia Isoflavones 4.8817569567
MESH:D000544 Alzheimer Disease resveratrol 2.6016183991 16162502
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001169 Arthritis, Experimental resveratrol 3.6217115116
MESH:D050197 Atherosclerosis resveratrol 3.3816873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 4.0519698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1119483382
MESH:D002545 Brain Ischemia resveratrol 4.5717600658
MESH:D001943 Breast Neoplasms Dietary Fats 2.3320435547
MESH:D001943 Breast Neoplasms resveratrol 2.3317651959 16393696 17534123
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.103084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.1016227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7616227395
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9519225199 15710769
MESH:D002318 Cardiovascular Diseases Isoflavones 8.2817689850
MESH:D002318 Cardiovascular Diseases resveratrol 8.2815458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 4.0619716837
MESH:D003092 Colitis resveratrol 4.3916474422
MESH:D003110 Colonic Neoplasms arsenite 6.1915037631
MESH:D003110 Colonic Neoplasms irinotecan 6.1917725105 17287894
MESH:D003110 Colonic Neoplasms resveratrol 6.1916338953
MESH:D015179 Colorectal Neoplasms irinotecan 3.7717454858 16391804 16303861 17159606 15273666 18509181 18259882
MESH:D015179 Colorectal Neoplasms Isoflavones 3.7717116718
MESH:D015179 Colorectal Neoplasms resveratrol 3.7716550006
MESH:D003327 Coronary Disease resveratrol 3.8716507316
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9416873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.1416286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0412392966 16177239 12594235 10774834 11529661 19739265 19370779 11834606 11461765 19420014 19923254 15619225 16393943 17522070 2444490 16227642 10915739 11421492 19416960 16109766 10663392 19085960 18713872 12958197 14725611 15968718 16485898 11287661 17562736 14986274 19164858 17906064 14550746 16081117 16781746 18071297 11743745 12705907 11739529 12153990 12540782
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0415265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema resveratrol 3.578985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2617872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1117923197
MESH:D005234 Fatty Liver Amiodarone 14.5214986274
MESH:D005234 Fatty Liver arsenite 14.5218296743
MESH:D005234 Fatty Liver Dietary Fats 14.5219004024 17967931 19551842 18296743
MESH:D005355 Fibrosis arsenite 9.9118296743
MESH:D005355 Fibrosis Dietary Fats 9.9118296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006529 Hepatomegaly Amiodarone 4.0115265979
MESH:D006561 Herpes Simplex resveratrol 4.4616876885
MESH:D019584 Hot Flashes Isoflavones 5.3014716179 17290160
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Amiodarone 16.598137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 16.5921332399
MESH:D006937 Hypercholesterolemia resveratrol 16.5917188708
MESH:D006949 Hyperlipidemias Dietary Fats 10.0421332399
MESH:D006949 Hyperlipidemias resveratrol 10.0416873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5017488730
MESH:D007037 Hypothyroidism Amiodarone 4.7717991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9117600658
MESH:D007249 Inflammation Dietary Fats 5.6020412841
MESH:D007249 Inflammation resveratrol 5.6016366677
MESH:D007251 Influenza, Human resveratrol 4.8616624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7016087638
MESH:D008064 Lipidoses Amiodarone 3.6515342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 7.2018296743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.2018296743
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 19460945 19784758 12587719 16610002 19014921 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms resveratrol 2.7719073162 19812893 19321006 20405173
MESH:D008133 Long QT Syndrome Amiodarone 3.7315350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms arsenite 2.3616809336
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.238985016 11606380
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008659 Metabolic Diseases resveratrol 4.5817112576
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009101 Multiple Myeloma resveratrol 3.6116267019 16490592 17049120 14749477 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1617962980
MESH:D009181 Mycoses Amiodarone 5.2212754197 17974566
MESH:D009203 Myocardial Infarction resveratrol 3.1016317513 17188708 16456233 16525036 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 4.1717015251 17125593
MESH:D009205 Myocarditis resveratrol 5.0417322642
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009374 Neoplasms, Experimental resveratrol 4.268985016
MESH:D009389 Neovascularization, Pathologic arsenite 4.7015738583
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.9317652729
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.6217929310
MESH:D009765 Obesity Dietary Fats 2.3318674790 21332399 19632207 17217161 20132043 18457598 20518802 11836018 16723640
MESH:D010024 Osteoporosis Isoflavones 4.2216562857
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4817513867
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.4616679765
MESH:D011471 Prostatic Neoplasms Isoflavones 3.7617571952 17219775 17374662 16365062
MESH:D011471 Prostatic Neoplasms resveratrol 3.7617675339 16731767 17636462 15767336 17718901 17804756
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9212490602 11597910 12832656
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9016325855
MESH:D015427 Reperfusion Injury resveratrol 3.3616317513 16314181 17520802 17058453 15827377
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4217431481
MESH:D012878 Skin Neoplasms resveratrol 3.1115837718 8985016
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6716321402
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D013959 Thyroid Diseases Amiodarone 5.0819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1218020914 19584973
MESH:D014062 Tongue Neoplasms resveratrol 4.4116227395
MESH:D016171 Torsades de Pointes Amiodarone 4.4711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 3.5120375083
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2917473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3717044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5617488730
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:05210 Colorectal cancer
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04510 Focal adhesion
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
REACT:11044 Signaling by Rho GTPases
KEGG:04620 Toll-like receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:05416 Viral myocarditis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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