AutismKB 2.0

Annotation Detail for RAD21


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Basic Information Top
Gene Symbol:RAD21 ( FLJ25655,FLJ40596,HR21,HRAD21,KIAA0078,MCD1,NXP1,SCC1,hHR21 )
Gene Full Name: RAD21 homolog (S. pombe)
Band: 8q24.11
Quick LinksEntrez ID:5885; OMIM: 606462; Uniprot ID:RAD21_HUMAN; ENSEMBL ID: ENSG00000164754; HGNC ID: 9811
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
Pathway IDPathway Name
500909M Phase
500976Mitotic Prometaphase
500868Mitotic Metaphase/Anaphase Transition
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of RAD21 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RAD21 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of RAD21 mRNAincreases expression 17023530
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD21 mRNAdecreases expression 20382639
D002945 Cisplatin RAD21 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RAD21 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAD21 mRNA]decreases reaction|increases expression 17854601
D017313 Fenretinide Fenretinide results in decreased expression of RAD21 mRNAdecreases expression 16671099
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RAD21 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in decreased expression of RAD21 mRNAdecreases expression 18445702
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RAD21 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D058186 Acute Kidney Injury Cisplatin 4.1317670903 12690470 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Cisplatin 5.0611798837 17638652
MESH:D000230 Adenocarcinoma Fenretinide 5.0610697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.983712494
MESH:D000236 Adenoma Diethylnitrosamine 6.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9017162532 17620307 19052882 19061943 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618177632 18985861 17688650 18396377 17157402 19232924 16609825 18940202 19460635 17507914 18558336 20603192 18775368 15238991 18316065
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1514601052
MESH:D001932 Brain Neoplasms Fenretinide 4.5116187019
MESH:D001943 Breast Neoplasms Cisplatin 2.1019526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1017474063
MESH:D001943 Breast Neoplasms Fenretinide 2.1016601279
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.157296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.153084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 9.1517982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1516569478 19383236 18393292 16830150 18506893 18665156 20727157 20512989 18210153 20524982 20214788 18978308 19539802 19107877 3084413 19919837 17173139 16807293 16288022 18971187 20007298 17162532 17761372 16878318 21159647 20514400 19052882 18056438 17978847 10737359 16328049 11831363 19208518 20432363 19171122 20101231 16502159 19335982 16779866 19394651 17138121 3581430 19822196 18691550 16935385 20084675 19701751 18788625 19519916 17055752 17428255 16698587 18494052 10672840 20935162 19418558 16540662 16681979 18785209
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 9.1516270382 17159502
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0912023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.326189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 5.3216274795
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.867505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.867505956 17174075 2727394 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.7116154183
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D015179 Colorectal Neoplasms Cisplatin 3.0015273666
MESH:D015179 Colorectal Neoplasms Fenretinide 3.0017273769
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.012524372 12868966 14531868 8970840 11906362 8156756 11298694 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.366482804 18289764 8291058 9022650 1440618 18692083 9328219 16192314 7440962 9653073 6679447 11289319 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3614550746 11743745 16485898 11739529 10663392 17906064 12392966 16781746 15619225 11421492 12153990 14725611 12540782 18713872 12958197 10915739 16393943 17522070 19164858 19416960 14986274 15968718 16227642 11461765 17562736 18071297 19085960 16081117 11529661 11287661 19420014 19739265 11834606 12705907 10774834 16109766 19923254 16177239 12594235 2444490 19370779
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3619107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.361733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Cisplatin 3.9812231392 15033597 19839026 12649298
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.523581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220426865
MESH:D004938 Esophageal Neoplasms Cisplatin 7.5217638652 16481741 16785472 15173087 15464296
MESH:D005234 Fatty Liver Diethylnitrosamine 14.1420387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.1419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.1414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Fenretinide 4.0016187019
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8215464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19176532 19772884 18467677
MESH:D006689 Hodgkin Disease Cisplatin 3.7416170182 16200630
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Acetaminophen 6.4315629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 6.4312649298 18289764 12231392 15190930 19839026
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007972 Leukoplakia, Oral Fenretinide 6.3116707609
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9120032147 18407596 18665156 19638242 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0316611625 19784758 12969438 19014921 19460945 12587719 16610002 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6320137499 20501860 19638242 19255062 19294768 19996281 19499222 21047994 19427195 21167192 21278145 21071580 12112319 20118626 16942905 19642983 20101389 10737359 12771043 2862719 18754104 19850985 19254457 20492335 19690152 19090486 19073162 20434301 18977376 18978307 18644402 20583210 18648771 9163691 19426721 2422723 15175105 20405173 19833225 19256749 20452335 19551842 19812893 15885732
MESH:D008113 Liver Neoplasms pirinixic acid 4.6320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.26598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2621159647 18079962 18308698 18544905 2563599 19126423 9362446 18775883 17942915 18093689 19009564 18253720 17174075 18282651 18164116 16267830 19004024 16842330 17854601 19519916 19539802 3124819
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Cisplatin 2.7011798837 17225452 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7021163286 20512841 6695378 20970405
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6710697514
MESH:D008545 Melanoma Cisplatin 3.9115577323 18176117 17023156 16248763 16809738 12883367 18505091 18332650 17761969 12374674 12393984 11135225 16432458
MESH:D008545 Melanoma Fenretinide 3.9116270382
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Cisplatin 3.3017638057
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009062 Mouth Neoplasms Fenretinide 4.4516274795
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.903581430 9029167
MESH:D009369 Neoplasms Cisplatin 8.8716773208
MESH:D009369 Neoplasms Fenretinide 8.8715958647 17353921
MESH:D009369 Neoplasms pirinixic acid 8.8717405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.616679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.618888407 16359493
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.938761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.9216303764
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Cisplatin 5.5319769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Fenretinide 5.5316133793
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 9.1219003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.1216540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 9.1215580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Fenretinide 4.0717024972
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.533692021
MESH:D012162 Retinal Degeneration Fenretinide 9.5316303925
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6314601052
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.853137016 11738929 11044598 17978042 16876388 15475178 14763951 1511512
MESH:D012878 Skin Neoplasms Fenretinide 3.5616467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Cisplatin 2.6515958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6518456281
MESH:D013736 Testicular Neoplasms Cisplatin 4.8115464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.563712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.567505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.868074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.8612973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.8616720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.4416803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 10.4416154183
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D014839 Vomiting Cisplatin 4.9811897121
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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