AutismKB 2.0

Annotation Detail for RAGE


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAGE ( MOK,RAGE1 )
Gene Full Name: renal tumor antigen
Band: 14q32
Quick LinksEntrez ID:5891; OMIM: 605762; Uniprot ID:MOK_HUMAN; ENSEMBL ID: ENSG00000080823; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
periodontitis
diabetic nephropathy
cardiovascular disease
atherosclerosis, coronary
CARDIOVASCULAR
diabetes, type 1
lung cancer, non-small cell
heart disease, ischemic
CANCER
nephropathy in other diseases
Proteinuria
Inflammation
RENAL
IMMUNE
Arthritis, Rheumatoid
METABOLIC
Stomach Neoplasms
diabetes, type 1 diabetes, type 2 diabetic nephropathy retinopathy, diabetic
obesity
psoriasis
C-reactive protein glycation inflammation insulin oxidative stress prostaglandin tumor necrosis factor alpha
retinopathy, diabetic
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RAGE mRNAdecreases expression 16788091
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of RAGE mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of RAGE mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of RAGE mRNAincreases expression 16002434
D004317 Doxorubicin RAGE protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of RAGE mRNAincreases expression 15223131
D016685 Mitomycin RAGE protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D017239 Paclitaxel RAGE protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RAGE mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in decreased expression of RAGE mRNAdecreases expression 17450228
D019772 Topotecan RAGE protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in decreased expression of RAGE mRNAdecreases expression 16140955
D014747 Vinblastine RAGE protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.5617418594
MESH:D000230 Adenocarcinoma Estradiol 4.5611473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2516206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.6515867366
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms Calcitriol 2.3811237771
MESH:D001943 Breast Neoplasms Doxorubicin 2.3818234424 15567936 16096432 15993339 18695136 16115903 16264153 15136595 18628466 17369602 19526202 17983394 16322301 15939500 16595493 18382427 16826403 15668708 15692762 17426702 16935488 11325840 15994142 15634643
MESH:D001943 Breast Neoplasms Estradiol 2.3817289903 16675129 17018787 18497071 17261762 14630087 19861407 12948864
MESH:D001943 Breast Neoplasms Paclitaxel 2.3818323546 16115903 16273361 18234424 16244791 11325840 15136595 18223236
MESH:D001943 Breast Neoplasms Tretinoin 2.3816873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.0318059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.0316924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 9.0316313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.0316507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.031917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.0716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.071485588
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 11.0211237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 11.026189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 11.0218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.0216096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.5815476868 17974986 17519947 16269455 16364871 17007740 16455267 15792986 17329180 16612575 17131338 16952015 16731534 17924179 16242529 17382496 16651473 16278810 17308081 15505089 16109756 18627295 15811867 17351982 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9716243910 17334414
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.5020056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.7018802399 18259882
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.7018802399
MESH:D015179 Colorectal Neoplasms Vinblastine 3.7018802399
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 14991402 9142499 9664655 9211117 10589399 9224671 17551590 8800419 9125849
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.4617416283
MESH:D004362 Drug Toxicity Doxorubicin 3.7318602426
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0315138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.7917359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.7911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 12.7916569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9116481741
MESH:D005124 Eye Abnormalities Tretinoin 3.6416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 7.8319224547
MESH:D005234 Fatty Liver pirinixic acid 7.8319236843 20131406
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Cyclosporine 9.0412168785 12639820
MESH:D005355 Fibrosis Tretinoin 9.0417994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Doxorubicin 7.4117150277
MESH:D005909 Glioblastoma Tretinoin 7.4117312396
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.0215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.939664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.5416244371 12587719 14766674 16707910 18674790 16330681 16879835 16495754 17875725 16144979 17888722 16244372 18006777
MESH:D006333 Heart Failure Doxorubicin 7.2117481944
MESH:D006333 Heart Failure pirinixic acid 7.2120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1016221962 19772884 18467677 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease Doxorubicin 12.8215147373 18501091 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 12.8212676792
MESH:D006689 Hodgkin Disease Vinblastine 12.8218180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007248 Infertility, Male sodium arsenite 3.0412646999 15346721
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 14.838314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 14.8315369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 14.8315618244
MESH:D007674 Kidney Diseases sodium arsenite 14.8320008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2017294898 17107899 16766008 16788101 15748426 17339181 12679006 19642359 16331271 9834237 17506722 19075265 17301526 19035177 17217047 17712046 17368321 16823087 17649720 19029980 16891316 17361223 16935935 19225113 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008080 Liposarcoma Paclitaxel 4.9117353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.0416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0416248980 18397230
MESH:D008113 Liver Neoplasms Mitomycin 7.7315113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.7320007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.7316712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.0616842330 17085340
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms Doxorubicin 2.6617418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 2.6617306315 16712894 15276417 19931552 17077188
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.1917654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 9.1914749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.2915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2917203775 11408345 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Doxorubicin 9.9816827129
MESH:D008545 Melanoma Paclitaxel 9.9816342250 12040289 12025231
MESH:D008545 Melanoma sodium arsenite 9.9819082730 16487513
MESH:D008545 Melanoma Tretinoin 9.9816752155
MESH:D008545 Melanoma Vinblastine 9.9815577323 16432458 16248763 16809738 17761969 15577320 18332650 18505091 12374674 18176117
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.7414749477
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.8115857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.8119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.2318259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.2315867366
MESH:D009369 Neoplasms pirinixic acid 8.4617405874
MESH:D009369 Neoplasms sodium arsenite 8.4611559025
MESH:D009369 Neoplasms Tretinoin 8.4616594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009401 Nephrosis Doxorubicin 4.8716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.5416889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 9.9916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 9.999125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.4812854658
MESH:D009436 Neural Tube Defects Tretinoin 7.489142499
MESH:D009447 Neuroblastoma Doxorubicin 7.4215555623
MESH:D009447 Neuroblastoma Topotecan 7.4215176712
MESH:D009503 Neutropenia Vinblastine 4.6617378895
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010014 Osteolysis Paclitaxel 5.1015867366
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010051 Ovarian Neoplasms Estradiol 11.5219401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 11.5211161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.5215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 11.5216936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.7215113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7215976015
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8816289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8816888761 15897917 15749863 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8817172428 17136230 16356831 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.3317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012509 Sarcoma Doxorubicin 4.0617203757 15625365 15675481 17710206 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012878 Skin Neoplasms Doxorubicin 13.9115692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.9119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.918532709
MESH:D012878 Skin Neoplasms Tretinoin 13.9116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6716767912 17203757 15625365
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6918396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 2.6917261132
MESH:D024801 Tauopathies Paclitaxel 4.9316930453
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.5217909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.3617653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.3617306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.6711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317678736 17638931 17334414 16364871
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34187
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved