AutismKB 2.0

Annotation Detail for RAD52


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAD52 ( - )
Gene Full Name: RAD52 homolog (S. cerevisiae)
Band: 12p13.33
Quick LinksEntrez ID:5893; OMIM: 600392; Uniprot ID:RAD52_HUMAN; ENSEMBL ID: ENSG00000002016; HGNC ID: 9824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
Pathway IDPathway Name
DNA Repair
No data
No data
Pathway IDPathway Name
501013Presynaptic phase of homologous DNA pairing and strand exchange
500047Assembly of the RAD51-ssDNA nucleoprotein complex
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
1944Breast cancer
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RAD52 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RAD52 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RAD52 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of RAD52 mRNAdecreases expression 15073043
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAD52 mRNAdecreases expression 20504355
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]decreases reaction|increases expression 16417649
D005047 Etoposide Etoposide results in increased expression of RAD52 proteinincreases expression 16417649
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of RAD52 mRNAdecreases expression 12057914
C031280 pyrazole pyrazole results in increased expression of RAD52 mRNAincreases expression 17945193
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2918653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.023712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.026695378
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.5414601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3817474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 2.3816322251
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.827296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8214691202 16217749 15553829 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1011298694 11906362 2524372 8156756 14531868 12868966 8970840 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.531440618 18692083 9328219 9653073 18648102 6679447 9022650 8291058 11289319 16192314 7440962 6482804 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5312540782 16485898 10663392 19739265 12153990 12958197 14550746 16781746 12594235 16109766 17906064 14986274 11739529 12392966 11529661 10774834 15619225 16227642 19420014 19416960 10915739 15968718 2444490 18071297 12705907 11461765 19164858 14725611 19923254 11834606 11743745 17562736 18713872 19085960 11287661 16177239 16081117 11421492 16393943 17522070 19370779
MESH:D056486 Drug-Induced Liver Injury pyrazole 9.5312499123
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7315328337 17637181 15821434
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.523581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5216530937
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D005334 Fever Lipopolysaccharides 4.2411852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006561 Herpes Simplex Etoposide 4.9010809021
MESH:D006689 Hodgkin Disease Etoposide 4.0817606976 15147373 16135485 16200630 18180244
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007249 Inflammation Lipopolysaccharides 2.9812878042 17963957 17237260 17255318 9205823
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 16467208 16968895 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616891316 16966277 16331271 17869043 15748426 19225113 15336539 17649720 9834237 12018890 19075265 11161223 19035177 15622746 19642359 12679006 16330433 16823087 16112521 17217047 17712046 11468182 12712474 15213294 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712587719 19014921 16611625 12969438 19784758 19460945 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8221137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.43598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4719825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4720064080 18816296 20135361 18569708 17053015 20464547 6695378 18520028 20869020
MESH:D008223 Lymphoma Etoposide 4.0912854902 12556972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2711468182 15949261 19417148 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.756679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7510525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6512819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.8315580305
MESH:D010190 Pancreatic Neoplasms Etoposide 5.8319003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.8912224865 11605937
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.6017172428
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 11.4016646077
MESH:D012512 Sarcoma, Ewing's Etoposide 11.4014601052
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013733 Testicular Diseases pyrazole 5.156499806
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.776582329 7505956 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.7719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.5916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.598074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.5911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.5917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
REACT:216 DNA Repair
KEGG:03440 Homologous recombination
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34180
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved