AutismKB 2.0

Annotation Detail for RALGDS


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Basic Information Top
Gene Symbol:RALGDS ( FLJ20922,RGDS,RGF,RalGEF )
Gene Full Name: ral guanine nucleotide dissociation stimulator
Band: 9q34.13-q34.2
Quick LinksEntrez ID:5900; OMIM: 601619; Uniprot ID:GNDS_HUMAN; ENSEMBL ID: ENSG00000160271; HGNC ID: 9842
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200113ErbB1 downstream signaling
Pathway IDPathway Name
P04393Ras Pathway
Pathway IDPathway Name
500627p38MAPK events
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RALGDS mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of RALGDS mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of RALGDS mRNAaffects expression 17562736
D000499 Allylamine Allylamine affects the expression of RALGDS mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RALGDS mRNAaffects expression 16483693
D002118 Calcium Calcium affects the expression of RALGDS mRNAaffects expression 15913539
D002713 Chlorine Chlorine results in increased expression of RALGDS mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 18636392
C014347 decitabine decitabine affects the expression of RALGDS mRNAaffects expression 17145863
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RALGDS mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RALGDS mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 17183730
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 18636392
C488333 Ro 65-7199 Ro 65-7199 affects the expression of RALGDS mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of RALGDS mRNAaffects expression 14610520
D013629 Tamoxifen Tamoxifen affects the expression of RALGDS mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 17942748
C402769 tipifarnib tipifarnib results in decreased expression of RALGDS mRNAdecreases expression 16403772
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RALGDS mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2811752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury Chlorine 4.3120601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0910965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 17688650 15238991 19460635 18316065 18940202 17157402 18775368 20603192 16609825 18177632 18558336 19232924 18985861 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.0620046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D001943 Breast Neoplasms decitabine 1.8719208741 18320071
MESH:D001943 Breast Neoplasms Tamoxifen 1.8717893378 18821012 20135344 19103187 19084267 18997820 18629630 16873071 19155303 19200415 18351453 16818667 11161223 17261762 19011961 21152245 19142967 19410462 18855134 20544844 18815881 17440819 19059307 19189210 16202921 21138602 19189212 19115204 19221464 17242785 19244106 20005174 16273361 18425577 18984771 20390343 19289846 20859285 19066611 15565566 19288272 17049068 19487384 15668708 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6616777450 18315731 14754758 17626835 19059883 18417511 15516495
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.503084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.5016924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5919215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8611677210 16105132 15861022 16919318 17333356 17681005 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4717688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9018071297 19739265 14550746 17522070 16393943 11287661 17562736 19164858 10663392 12958197 15619225 2444490 19370779 11421492 16781746 11834606 11529661 19085960 11739529 19923254 11461765 10915739 11743745 16109766 12392966 14986274 14725611 16081117 19416960 16227642 12540782 17906064 10774834 15968718 12153990 12594235 19420014 16177239 18713872 16485898 12705907
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.9019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0320544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.923922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.576254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0115345470
MESH:D005234 Fatty Liver Tamoxifen 13.0114986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 13.0114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4719215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0515340226 18606429 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6116612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male decitabine 6.6717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1912587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.0516316344
MESH:D007938 Leukemia decitabine 3.0618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.9817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9818460780 18206229 18704418 19010910 17679729 19387464
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9816294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6219784758 12587719 12969438 19460945 16611625 11587558 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 4.3716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0912151625
MESH:D008171 Lung Diseases Ozone 3.368266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Ozone 4.918597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 4.9118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9119555203 11884234
MESH:D008175 Lung Neoplasms tipifarnib 4.9116885199
MESH:D008223 Lymphoma decitabine 3.4019470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5711731420 19196722 14580682 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 6.5716648579
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008545 Melanoma decitabine 3.3817785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.3819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D008881 Migraine Disorders Valproic Acid 3.1718803445 18765137
MESH:D009101 Multiple Myeloma decitabine 3.3318172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.4718608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms decitabine 2.7019470736 17925555 19116145
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4116049721 12819281
MESH:D010024 Osteoporosis Calcium 3.7717882678
MESH:D010051 Ovarian Neoplasms decitabine 2.6419259094 19331143
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7619294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5011550810
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4411896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.4420603192
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.5411422049 12752131
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.9219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.9219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8918551238
MESH:D012640 Seizures Valproic Acid 5.8916876388 1511512 11738929 3137016 14763951 11044598 15475178 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3117967635
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.3017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.308653321 17572228 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014604 Uveal Neoplasms decitabine 4.9117785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:05210 Colorectal cancer
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34200
    • No data
    No data
    Releated drug ID Related drug Name
    PA450191lecithin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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