AutismKB 2.0

Annotation Detail for RAN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAN ( ARA24,Gsp1,TC4 )
Gene Full Name: RAN, member RAS oncogene family
Band: 12q24.33
Quick LinksEntrez ID:5901; OMIM: 601179; Uniprot ID:RAN_HUMAN; ENSEMBL ID: ENSG00000132341; HGNC ID: 9846
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Regulatory RNA pathways
Influenza Infection
HIV Infection
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
200097Sumoylation by RanBP2 regulates transcriptional repression
200091FoxO family signaling
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200166Aurora A signaling
200026Canonical NF-kappaB pathway
No data
Pathway IDPathway Name
500734Late Phase of HIV Life Cycle
500696NEP/NS2 Interacts with the Cellular Export Machinery
500749Interactions of Rev with host cellular proteins
500744Rev-mediated nuclear export of HIV-1 RNA
500750Nuclear import of Rev protein
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RAN mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RAN mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAN mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of RAN proteinincreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of RAN mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RAN proteinincreases expression 17292933
C032036 bromobenzene bromobenzene results in increased expression of RAN mRNAincreases expression 12628495
D002104 Cadmium Cadmium results in increased expression of RAN mRNAincreases expression 16624402
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of RAN mRNAincreases expression 16624402
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAN mRNAaffects cotreatment|affects expression 17602206
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA]decreases reaction|increases expression 19172522
C014347 decitabine decitabine affects the expression of RAN mRNAaffects expression 17524140
C014347 decitabine [decitabine co-treated with trichostatin A] results in decreased expression of RAN mRNAaffects cotreatment|decreases expression 17524140
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAN mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RAN mRNAincreases expression 19638242
D004610 Ellagic Acid Ellagic Acid results in decreased expression of RAN mRNAdecreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RAN mRNAincreases expression 16174780
19400957
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RAN mRNAincreases expression 16174780
17108234
19400957
D006918 Hydroxyurea Hydroxyurea results in decreased expression of RAN mRNAdecreases expression 12929121
D007052 Ibuprofen Ibuprofen affects the expression of RAN proteinaffects expression 18351690
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA]decreases reaction|increases expression 19172522
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of RAN mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of RAN mRNAincreases expression 16221962
18301758
D011374 Progesterone Progesterone results in decreased expression of RAN mRNAdecreases expression 18037150
C045950 propiconazole propiconazole results in increased expression of RAN mRNAincreases expression 19363144
C487081 PXD101 PXD101 results in decreased expression of RAN mRNAdecreases expression 19606018
C059514 resveratrol resveratrol results in decreased expression of RAN mRNAdecreases expression 12002526
12569576
C009277 sodium arsenate sodium arsenate results in increased expression of RAN mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of RAN mRNAincreases expression 19822182
C017947 sodium arsenite sodium arsenite results in decreased expression of RAN proteindecreases expression 19072884
D013629 Tamoxifen Tamoxifen results in increased expression of RAN mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of RAN mRNAincreases expression 19400957
D013853 Thioacetamide Thioacetamide results in increased expression of RAN mRNAincreases expression 16297948
C066340 tolcapone tolcapone binds to RAN proteinaffects binding 19783845
C032910 triadimefon triadimefon results in increased expression of RAN mRNAincreases expression 19363144
C012589 trichostatin A trichostatin A results in decreased expression of RAN mRNAdecreases expression 19606018
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in decreased expression of RAN mRNAaffects cotreatment|decreases expression 17524140
D014501 Uranium Uranium affects the expression of RAN mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of RAN mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.6919106084
MESH:D058186 Acute Kidney Injury Ibuprofen 8.156375363
MESH:D058186 Acute Kidney Injury resveratrol 8.1516538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.0911850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.0918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6614692618
MESH:D000230 Adenocarcinoma Ibuprofen 6.6610697514
MESH:D000236 Adenoma Benzo(a)pyrene 10.156695378
MESH:D000236 Adenoma Diethylnitrosamine 10.1510737359 6695378
MESH:D000236 Adenoma resveratrol 10.1515688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0618056438 17620307 17162532 16434500 19052882 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5917306315 16712894
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.9811080934
MESH:D000544 Alzheimer Disease Ibuprofen 6.4618351690
MESH:D000544 Alzheimer Disease resveratrol 6.4616183991 16162502
MESH:D000544 Alzheimer Disease tolcapone 6.4620150427
MESH:D000707 Anaphylaxis Ibuprofen 4.949532969
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7215885639
MESH:D001169 Arthritis, Experimental resveratrol 6.7217115116
MESH:D050197 Atherosclerosis Cadmium 6.4215687053
MESH:D050197 Atherosclerosis resveratrol 6.4216873680 17967414
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2619483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 8.2619483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 3.9515665606 15380490 15845082
MESH:D002545 Brain Ischemia Ibuprofen 9.4915837124
MESH:D002545 Brain Ischemia resveratrol 9.4917600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8017474063 20146248
MESH:D001943 Breast Neoplasms decitabine 2.8019208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8017474063
MESH:D001943 Breast Neoplasms Progesterone 2.8016175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 2.8017651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 2.8016273361 19142967 19244106 19221464 20859285 20135344 19059307 11161223 21138602 17242785 19288272 18855134 15668708 18997820 17440819 17893378 19103187 19155303 17049068 19011961 19289846 19189212 19200415 19189210 19487384 19084267 19410462 18984771 21152245 19066611 17261762 18821012 15565566 16818667 20390343 16202921 16873071 20065188 18425577 20005174 20544844 18815881 19115204 18629630 18351453
MESH:D002100 Cachexia Ibuprofen 5.1615141370
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.2316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.2316705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.2317173139 16698587 20084675 16878318 17978847 19208518 19519916 20214788 19335982 19701751 19171122 16569478 18978308 16935385 17761372 18971187 20524982 19418558 20935162 17162532 16807293 3084413 21159647 18494052 16540662 10672840 17428255 18056438 11831363 20727157 18506893 19052882 16779866 18788625 20007298 19107877 16288022 18210153 19822196 18691550 18785209 20514400 17138121 18393292 16830150 17055752 19394651 19539802 3581430 16681979 16328049 16502159 20432363 18665156 10737359 20512989 19383236 19919837 20101231
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.2316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.2317306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.2317997003
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2816675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.0220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.0219215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.0216227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.0218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3517572228
MESH:D002318 Cardiovascular Diseases clopidogrel 7.2820180610
MESH:D002318 Cardiovascular Diseases resveratrol 7.2815458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.336135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.3317332340
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.3317174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.3320056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8819052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.8818291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9916919318 17110522 16105132 11677210 15861022 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 6.9919176532
MESH:D002972 Cleft Palate triadimefon 3.6016781842
MESH:D003092 Colitis resveratrol 3.8316474422
MESH:D003110 Colonic Neoplasms decitabine 3.7417616700
MESH:D003110 Colonic Neoplasms resveratrol 3.7416338953
MESH:D015179 Colorectal Neoplasms decitabine 2.6418981723
MESH:D015179 Colorectal Neoplasms resveratrol 2.6416550006
MESH:D003327 Coronary Disease resveratrol 3.5516507316
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.2710525206
MESH:D019465 Craniofacial Abnormalities triadimefon 3.2715834900 16875885
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.8818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.8818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003866 Depressive Disorder tolcapone 4.0911224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.6410440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5216873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1220387270
MESH:D003928 Diabetic Nephropathies resveratrol 8.1816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury bromobenzene 17.1712628495 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.1719107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 17.1718186108
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 17.1712963478
MESH:D056486 Drug-Induced Liver Injury tolcapone 17.1716604736 19783845
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.3018446180 18450898 16133044
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.0811455177
MESH:D004487 Edema pirinixic acid 6.0012083418
MESH:D004487 Edema resveratrol 6.008985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.5012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.5017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 19.5017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.5019031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.9719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.9719294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8420544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Ibuprofen 8.6215652904
MESH:D004715 Endometriosis Progesterone 8.6216134523
MESH:D019446 Endotoxemia Ibuprofen 9.7911545620
MESH:D019446 Endotoxemia Lipopolysaccharides 9.7917637181 15328337 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5417923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3216530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.3215150132 16704527 16805852 15547721 15878914 15547733 16510608 15264214 15623463
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.6319578428
MESH:D005218 Fat Necrosis Thioacetamide 5.4016456712
MESH:D005234 Fatty Liver Diethylnitrosamine 16.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.4715345470
MESH:D005234 Fatty Liver pirinixic acid 16.4720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 16.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0516709447
MESH:D005334 Fever Ibuprofen 8.6316997862
MESH:D005334 Fever Lipopolysaccharides 8.6311852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3716452187
MESH:D005909 Glioblastoma trichostatin A 3.6318801729
MESH:D018149 Glucose Intolerance sodium arsenate 4.7919446573
MESH:D006258 Head and Neck Neoplasms decitabine 3.2819215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.4920471113
MESH:D006333 Heart Failure pirinixic acid 2.3520558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1216366002
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3018665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.9216456712
MESH:D006529 Hepatomegaly pirinixic acid 12.9916221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly propiconazole 12.9917178689 17178688
MESH:D006529 Hepatomegaly triadimefon 12.9917178688 17178689
MESH:D006561 Herpes Simplex resveratrol 3.8716876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9012676792
MESH:D006937 Hypercholesterolemia resveratrol 3.7317188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006949 Hyperlipidemias resveratrol 3.7416873680
MESH:D006984 Hypertrophy Ibuprofen 4.7016672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116945680 16569931
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.5216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.4715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.4717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male decitabine 10.0317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.0317937319
MESH:D007248 Infertility, Male sodium arsenite 10.0315346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 17.8518785209
MESH:D007249 Inflammation Ibuprofen 17.853291741
MESH:D007249 Inflammation Lipopolysaccharides 17.8512878042 17255318 17237260 9205823 17963957
MESH:D007249 Inflammation Progesterone 17.8515869954
MESH:D007249 Inflammation resveratrol 17.8516366677
MESH:D007249 Inflammation Tamoxifen 17.8519457130
MESH:D007251 Influenza, Human resveratrol 4.2316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4316306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3417255318
MESH:D007569 Jaw Abnormalities triadimefon 4.6815834900 15992940
MESH:D007674 Kidney Diseases Cadmium 9.2916226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 9.2916962696
MESH:D007674 Kidney Diseases sodium arsenite 9.2920008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.9616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.9616705839
MESH:D007680 Kidney Neoplasms Tamoxifen 10.9618625569
MESH:D007938 Leukemia decitabine 2.9218980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 9.1217236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Hydroxyurea 9.1216532439
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0718460780 18206229 17679729 19010910 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.0718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1518055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3816087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.3915821434
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6518665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.6612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.6618564211
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.6615095483 11682029 18031379 18416461 18032466 15075984 18295389 16098781 18458672 18263696 18615449 17127702 15474484 12531686 12085344 14739098 16248980 12175628 18606216 15362042 15716488 15078482 15158331 11481614 15316131 17050028 17355460 15465738 16489207 12679928 12557150 18395095 16126171 15334695 12891558 15288473 10677585 17629604 15288472 16343077 18380797 16511523 11172339 17292413 16097051
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8017034775
MESH:D008107 Liver Diseases propiconazole 8.8019363144
MESH:D008107 Liver Diseases Thioacetamide 8.8016337175 15158337 18374380
MESH:D008107 Liver Diseases triadimefon 8.8019363144
MESH:D017114 Liver Failure, Acute Thioacetamide 4.0415313186 15633222 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 31.807678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 31.8020195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 31.8017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.8019090486 12771043 18977376 19812893 18978307 16942905 19294768 10737359 19551842 9163691 15885732 19499222 20434301 21071580 20101389 20137499 20501860 20405173 19426721 19833225 18648771 19073162 2422723 20583210 18754104 19427195 19690152 19638242 19850985 19256749 20118626 21167192 15175105 20492335 19254457 21278145 18644402 19642983 2862719 19255062 21047994 20452335 19996281 12112319
MESH:D008113 Liver Neoplasms pirinixic acid 31.8020007298 15890375 16377806
MESH:D008113 Liver Neoplasms propiconazole 31.8019028983
MESH:D008113 Liver Neoplasms resveratrol 31.8019073162 19812893 19321006 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 31.8015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 31.8016684651
MESH:D008113 Liver Neoplasms triadimefon 31.8019028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.642876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.6416267830 19126423 17854601 18079962 17174075 18164116 19539802 9362446 19009564 17942915 2563599 18093689 21159647 18253720 18775883 19519916 19004024 18308698 16842330 3124819 18544905 18282651
MESH:D008114 Liver Neoplasms, Experimental propiconazole 12.6417178689
MESH:D008114 Liver Neoplasms, Experimental triadimefon 12.6417178689
MESH:D008171 Lung Diseases sodium arsenite 2.9719095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.3017365036
MESH:D055370 Lung Injury Lipopolysaccharides 8.3021114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.5220464547 20135361 17053015 18569708 20869020 6695378 18816296 18520028 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.5220970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 4.5216712894 17306315 17077188 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 4.5218625569
MESH:D008223 Lymphoma decitabine 3.2019470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6214749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.9715688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.9719428831
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 12.7110697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.7117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.7111606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.7116827153 19196722 11731420 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.2319453300
MESH:D008545 Melanoma decitabine 9.1616505122 17785578
MESH:D008545 Melanoma resveratrol 9.1617992120
MESH:D008545 Melanoma sodium arsenite 9.1616487513 19082730
MESH:D008545 Melanoma Tamoxifen 9.1612393984 19393235
MESH:D008545 Melanoma trichostatin A 9.1616505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0618303189 16966607 16166281
MESH:D008659 Metabolic Diseases resveratrol 4.1017112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9616381670
MESH:D009101 Multiple Myeloma decitabine 11.0118172295
MESH:D009101 Multiple Myeloma resveratrol 11.0117049120 14749477 17935668 17164350 16267019 16490592
MESH:D009101 Multiple Myeloma trichostatin A 11.0118172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5818186108
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2116882708 18608210 19010910 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 5.3019151258
MESH:D009203 Myocardial Infarction resveratrol 5.3017188708 16317513 16525036 17015251 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 3.7617125593 17015251
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7116411023
MESH:D009205 Myocarditis resveratrol 4.4517322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.3118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.3118551238 7678174
MESH:D009362 Neoplasm Metastasis clopidogrel 8.9411875746
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.943581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.9419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.5611141357
MESH:D009369 Neoplasms decitabine 10.5619116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 10.5617405874
MESH:D009369 Neoplasms sodium arsenite 10.5611559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.228985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.2220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.676375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.1510961664
MESH:D009436 Neural Tube Defects sodium arsenate 6.9711749123 18186108 19446573 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.9712854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6920387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6917652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0016049721
MESH:D010003 Osteoarthritis Ibuprofen 3.947009135
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9717513867
MESH:D010051 Ovarian Neoplasms decitabine 10.5019259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 10.5016525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.5015276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 10.5019331143
MESH:D010146 Pain Ibuprofen 3.683291741
MESH:D010149 Pain, Postoperative Ibuprofen 4.8316678543
MESH:D010190 Pancreatic Neoplasms decitabine 11.4719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4716540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 11.4712384795
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.4719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010300 Parkinson Disease tolcapone 3.4820334432 8635184 11432539 16758261 10651109 19783845 18328768 9591521 17089403 8739811 19578428 7566641 9754991 11586115 11793426 9305320 9333106 20216409 1977408 9708959 11746615
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0715687053
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5910923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.2411605937 12224865
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.292563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.8716679765
MESH:D055728 Primary Myelofibrosis decitabine 11.4117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.4117616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.0517075824
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.0517409433
MESH:D011471 Prostatic Neoplasms resveratrol 2.0517718901 17636462 17804756 15767336 16731767 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0519789329 18798265
MESH:D011507 Proteinuria Ibuprofen 4.346375363
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9117365031 15814490 17975199 17322281
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2716325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.0619058328
MESH:D015427 Reperfusion Injury resveratrol 6.0617058453 16314181 16317513 15827377 17520802
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5310835634
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.8219371211
MESH:D012208 Rhabdomyosarcoma decitabine 4.1219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.1818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.6619755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 8.6615837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 8.6619524636 18572023
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5116709447
MESH:D013088 Spermatocele Tamoxifen 10.5116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.8316503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.8319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4620155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.4612958204 17575124
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2116321402
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013964 Thyroid Neoplasms decitabine 10.8017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.807505956
MESH:D013964 Thyroid Neoplasms triadimefon 10.8017178689
MESH:D014062 Tongue Neoplasms resveratrol 3.9416227395
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.6319578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 18.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 18.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.2417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.2417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.2416452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.2417572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.9510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.9510091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.6717473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.6711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5214692618
MESH:D014594 Uterine Neoplasms resveratrol 8.5217044934
MESH:D014604 Uveal Neoplasms decitabine 4.6017785578
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.8819057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0017488730
MESH:D014820 Vitiligo tolcapone 4.9010573327
Pathway ID Pathway Name
REACT:6185 HIV Infection
REACT:6167 Influenza Infection
REACT:12472 Regulatory RNA pathways
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34205
    • No data
    No data
    Releated drug ID Related drug Name
    PA451578tacrolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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