AutismKB 2.0

Annotation Detail for RANBP1


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Basic Information Top
Gene Symbol:RANBP1 ( HTF9A,MGC88701 )
Gene Full Name: RAN binding protein 1
Band: 22q11.21
Quick LinksEntrez ID:5902; OMIM: 601180; Uniprot ID:RANG_HUMAN; ENSEMBL ID: ENSG00000099901; HGNC ID: 9847
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RANBP1 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RANBP1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RANBP1 proteindecreases expression 20097212
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RANBP1 mRNAdecreases expression 20504355
C053541 bicalutamide bicalutamide results in decreased expression of RANBP1 mRNAdecreases expression 15638997
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RANBP1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of RANBP1 mRNAincreases expression 20106945
D004317 Doxorubicin RANBP1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RANBP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RANBP1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RANBP1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of RANBP1 mRNA]affects reaction|decreases expression 15016801
C027869 lingzhi lingzhi results in decreased expression of RANBP1 proteindecreases expression 18422750
C037219 quinoline quinoline analog results in decreased expression of RANBP1 proteindecreases expression 18645022
C025462 sulindac sulfide sulindac sulfide results in increased expression of RANBP1 mRNAincreases expression 12734198
D013629 Tamoxifen Tamoxifen affects the expression of RANBP1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RANBP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RANBP1 mRNAincreases expression 17942748
D019772 Topotecan RANBP1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin affects the expression of RANBP1 proteinaffects expression 15789344
D014315 Triterpenes Triterpenes results in decreased expression of RANBP1 proteindecreases expression 18422750
D014635 Valproic Acid Valproic Acid results in decreased expression of RANBP1 mRNAdecreases expression 19101580
D014747 Vinblastine RANBP1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1915322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.198875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8919490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 10.1017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1014692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.1017638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0818759972
MESH:D000550 Amblyopia Valproic Acid 5.2017688650
MESH:D000740 Anemia Fluorouracil 8.5515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001321 Autistic Disorder Valproic Acid 2.0118177632 18985861 17688650 18396377 18316065 18558336 18775368 20603192 16609825 15238991 17157402 19232924 18940202 19460635 17507914
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0520046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.938888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7717150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9420146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9415994142 17369602 16264153 18234424 18695136 16322301 15136595 16595493 15692762 11325840 15993339 15567936 16826403 19526202 15939500 15668708 18382427 17426702 16096432 15634643 18628466 16115903 17983394 16935488
MESH:D001943 Breast Neoplasms Fluorouracil 2.9419217205 16110121 16557594 16595493 15136595 18357371 18608205
MESH:D001943 Breast Neoplasms Tamoxifen 2.9419011961 21152245 19142967 17440819 20544844 18997820 17049068 16873071 21138602 19155303 18815881 20005174 19115204 18984771 18855134 19200415 19288272 16273361 19189212 19244106 19410462 17261762 19487384 18821012 17893378 19059307 15668708 16202921 19189210 20859285 19084267 20065188 15565566 16818667 19221464 19103187 18351453 19066611 19289846 20135344 11161223 17242785 18425577 20390343 18629630
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9416443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.5015673190 16011737 15700767 16050911 15721981 16124888 16227642 16097048 18705752 3786805 16192424 10355542
MESH:D002252 Carbon Tetrachloride Poisoning lingzhi 10.5015673190
MESH:D002276 Carcinoid Tumor Doxorubicin 12.2616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.2616051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 14.007296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.0018788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 14.0016023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.0016332177 17971768 17045692 18930000 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular quinoline 14.00598648
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.001917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4312391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 15.237296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 15.2316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 15.2318695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 15.231485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.7120419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.716189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.7116757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5017007740 15811867 16455267 16109756 17928571 17351982 17924179 17308081 16278810 18627295 16242529 15476868 16952015 16731534 17974986 17382496 17131338 17519947 16364871 15792986 17329180 15505089 16612575 16269455 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9317334414 16243910
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.477505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.1919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.1919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1916919318 17333356 16105132 11677210 17681005 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2317172411 16510598 18772588 17725105 17016597 15001691 17169374 16340194 17287894 17018589
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5818288408 17255274 18448328 20501625 17594712 16524972 15289873 16282729 17016601 16331619 16391804 17094418 18949393 18509181 18802399 16303861 17454858 15148649 14970324 18383874 17695437 17401013
MESH:D015179 Colorectal Neoplasms Vinblastine 3.5818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7316925845 9224671 10589399 9664655 17551590 9211117 8800419 9125849 9142499 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7317688650 8888407 16575769
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 11906362 11298694 14531868 8970840 2524372 18759878 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.452952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.8918289764 1440618 18692083 11289319 8291058 18648102 9022650 6679447 7440962 9653073 9328219 16192314 6482804
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.8921278145 2869522 7179309 19336974 3732212 9327722 6623471 7120509 10092053 17522070 6884620 4309450 10915739 7440962 15998439 16227642 15027814 16177239 11566570 19085960 15968718 3786805
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.8917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.891733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 8.0018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0011462148
MESH:D004421 Dystonia Valproic Acid 4.011851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.3217359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.3220544844 19155303 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.893922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.556426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.033659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.173581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1716337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.729664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2216045604 17595544 12795759 16239168 19224547 12631006 61145 15959796
MESH:D005234 Fatty Liver Cyclosporine 24.2219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2215345470
MESH:D005234 Fatty Liver Tamoxifen 24.2214986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 24.2214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0918558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.3219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.3219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.8218705752
MESH:D005355 Fibrosis Cyclosporine 20.8212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.8220067830
MESH:D005355 Fibrosis Tretinoin 20.8217994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Doxorubicin 7.1517150277
MESH:D005909 Glioblastoma Tretinoin 7.1517312396
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.8115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.8115162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.8116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.969664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.4516244372 12587719 17875725 14766674 18006777 16879835 16495754 18674790 16244371 16707910 16330681 16144979 17888722
MESH:D006333 Heart Failure Doxorubicin 3.3117481944
MESH:D006390 Hemangioendothelioma quinoline 5.87598648
MESH:D006394 Hemangiosarcoma Doxorubicin 9.4915692506
MESH:D006394 Hemangiosarcoma quinoline 9.49598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.096705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8512621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 7.6717606976 18501091 15147373
MESH:D006689 Hodgkin Disease Vinblastine 7.6718180244 18501091
MESH:D006849 Hydrocephalus Valproic Acid 4.8317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Tamoxifen 4.8119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8112200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.028314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 6.0215699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1116707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.466582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.4612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 17.4616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.4618625569
MESH:D007938 Leukemia Tretinoin 2.7517143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8617596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8616294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219225113 16766008 17361223 16935935 17506722 16331271 17649720 17301526 19029980 17217047 16823087 17368321 19075265 15748426 16891316 9834237 17107899 17712046 17294898 16140955 19642359 16788101 12679006 17339181 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7816221502 16239168 11408273 17334410 17174718 11903743 16943688 17157831 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6912898905 12445418 16027843 16015684 18251166 18395095 15057751 17823541 18317297 12666154 18339082 17900296 13678700 15370692 12632512 14512876 18279442 16033810 17721639 16248980 12667390 15673190 12741479 18472332 18429990 15931870 10355542 14716496 18395914 14620537 17525996 17698563 18481824 18277467 12445421 17922224 15876570 18263696 15650968 17481882 18418968 15925388 18156304 17976157 17631135 16097048 18166357 12649538 20821823 15818738 15362042 17761835 17557913 17869086 17714472 18054572 18187930 14716833 14724832 14748882 18705752 18420326 15893842 18006644 15996030 15052691 17766677 17805973 18412020 16011737 18376398 15730626 12958196 17565644 17944888 12609069 16192424 12632514 16116963 18472094 12546737 16638106 12586293 15338365 17640975 17708605 18205269 16136751 11481614 18210741 15123356 12389079 15959796
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.6916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental lingzhi 8.6915673190
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6916248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0715830285 16964402 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.0620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.0619294768
MESH:D008113 Liver Neoplasms Fluorouracil 14.0618383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 14.0616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.89598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.8912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.8916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.8912151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2317228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5318520028 18569708 6695378 18816296 20064080 20464547 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Doxorubicin 6.5317418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 6.5315246190
MESH:D008175 Lung Neoplasms Tamoxifen 6.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008223 Lymphoma Doxorubicin 3.4316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5315621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.0515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0514580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Doxorubicin 7.2916827129
MESH:D008545 Melanoma Tamoxifen 7.2912393984 19393235
MESH:D008545 Melanoma Tretinoin 7.2916752155
MESH:D008545 Melanoma Vinblastine 7.2912374674 16809738 17761969 16432458 15577320 15577323 18176117 16248763 18332650 18505091
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008654 Mesothelioma Doxorubicin 3.0417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1618765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7517415656
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.998888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.3117596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9319429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 13.523581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 13.5218259882
MESH:D009362 Neoplasm Metastasis quinoline 13.52598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 13.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.1511141357
MESH:D009369 Neoplasms Fluorouracil 8.1516928823 18600527 18239605
MESH:D009369 Neoplasms Tretinoin 8.1516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19200415 19189210
MESH:D009401 Nephrosis Doxorubicin 4.7316899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.1718481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.1716889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3814600291
MESH:D009421 Nervous System Malformations Tretinoin 9.389125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.966679447
MESH:D009436 Neural Tube Defects Tretinoin 11.969142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.968888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 7.2215555623
MESH:D009447 Neuroblastoma Topotecan 7.2215176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009503 Neutropenia Vinblastine 4.5317378895
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3316936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2915113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3511222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.3520603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bicalutamide 1.8818487222 15638997 17914592 19240160 19011039
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8816729912 15897917 18437689 16888761 16868541 15749863
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.5112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9718286688 15538739 18722050 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.1817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.7316283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.7319155313
MESH:D012509 Sarcoma Doxorubicin 3.9516767912 18313854 15675481 15625365 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7111044598 11738929 1511512 16876388 3137016 15475178 14763951 17978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.3919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.3915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.3916192470
MESH:D012878 Skin Neoplasms Tretinoin 13.3916467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5316767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.342093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3418567086 16424979 19015929 18396642 15786421 17522103 16951190 17498489 17172411 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D013276 Stomach Ulcer lingzhi 4.9712467913
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.803712494 6587162 1399818 7505956 6582329
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.8016010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 11.8017045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.7016280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.7016051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.2017262798
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.493119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.798074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7917053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.7917653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.7916712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.608888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.3216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.3216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5514692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.5518645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.0115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817638931 17334414 16364871 17678736
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
REACT:6185 HIV Infection
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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