AutismKB 2.0

Annotation Detail for RAP1A


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Basic Information Top
Gene Symbol:RAP1A ( KREV-1,KREV1,RAP1,SMGP21 )
Gene Full Name: RAP1A, member of RAS oncogene family
Band: 1p13.2
Quick LinksEntrez ID:5906; OMIM: 179520; Uniprot ID:RAP1A_HUMAN; ENSEMBL ID: ENSG00000116473; HGNC ID: 9855
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04972Pancreatic secretion
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Diabetes pathways
Signalling by NGF
Hemostasis
Signaling in Immune system
Integration of energy metabolism
Integrin cell surface interactions
Pathway IDPathway Name
200157EPO signaling pathway
200062TCR signaling in naive CD8+ T cells
200098Class I PI3K signaling events
200022TCR signaling in naive CD4+ T cells
200051Reelin signaling pathway
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00034Integrin signalling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500630Frs2-mediated activation
500631ARMS-mediated activation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1850Herpes
1942Emphysema
1969Azoospermia
1976Squamous cell cancer
1986Eating disorder
No data
Desease Name
Osteoporosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RAP1A mRNAaffects expression 21346803
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of RAP1A mRNAdecreases expression 16514628
C534317 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RAP1A proteinincreases expression 12671036
C534317 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol Mevalonic Acid affects the reaction [6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAP1A mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of RAP1A mRNAdecreases expression 18191166
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
D002118 Calcium Calcium promotes the reaction [ibandronic acid results in decreased prenylation of RAP1A protein]decreases prenylation|increases reaction 18190680
D004317 Doxorubicin [zoledronic acid co-treated with Doxorubicin] results in decreased expression of RAP1A protein modified formaffects cotreatment|decreases expression 19789217
C479799 (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of RAP1A mRNAdecreases expression 15528975
D004958 Estradiol Estradiol results in increased expression of RAP1A mRNAincreases expression 16514628
C065180 fluvastatin fluvastatin results in decreased prenylation of RAP1A proteindecreases prenylation 16996129
C070081 fulvestrant fulvestrant results in decreased expression of RAP1A mRNAdecreases expression 16514628
C017338 geranylgeraniol [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified formaffects cotreatment|decreases expression 19819230
C017338 geranylgeraniol geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein]decreases geranoylation|decreases reaction 16539721
C015234 geranyl pyrophosphate [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified formaffects cotreatment|decreases expression 19819230
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RAP1A mRNAaffects cotreatment|increases expression 17183730
C073007 ibandronic acid Calcium promotes the reaction [ibandronic acid results in decreased prenylation of RAP1A protein]decreases prenylation|increases reaction 18190680
C073007 ibandronic acid ibandronic acid results in decreased prenylation of RAP1A proteindecreases prenylation 18190680
D007657 Ketone Bodies Ketone Bodies results in decreased expression of RAP1A mRNAdecreases expression 16807920
D008610 Menthol Menthol results in increased expression of RAP1A proteinincreases expression 12671036
D008610 Menthol Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008610 Menthol Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
C104820 N-(3-(aminomethyl)benzyl)acetamidine N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
D009569 Nitric Oxide Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]increases activity|increases reaction 16963453
C032208 perilla alcohol Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
C032208 perilla alcohol perilla alcohol results in increased expression of RAP1A proteinincreases expression 12671036
C033342 perillaldehyde Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]affects reaction|increases expression 12671036
C033342 perillaldehyde perillaldehyde results in increased expression of RAP1A proteinincreases expression 12671036
D020849 Raloxifene Raloxifene results in decreased expression of RAP1A mRNAdecreases expression 16514628
C073008 risedronic acid risedronic acid results in decreased prenylation of RAP1A proteindecreases prenylation 16675582
C017947 sodium arsenite sodium arsenite results in increased expression of RAP1A mRNAincreases expression 12016162
C416927 SU 6656 SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RAP1A mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of RAP1A mRNAincreases expression 19101580
C009687 wortmannin wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C087958 YM 529 YM 529 results in decreased prenylation of RAP1A proteindecreases prenylation 17874104
C088658 zoledronic acid geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein]decreases geranoylation|decreases reaction 16539721
C088658 zoledronic acid zoledronic acid results in decreased geranoylation of RAP1A proteindecreases geranoylation 16539721
C088658 zoledronic acid zoledronic acid results in decreased prenylation of RAP1A proteindecreases prenylation 19621390
16996129
16602111
C088658 zoledronic acid [zoledronic acid co-treated with Doxorubicin] results in decreased expression of RAP1A protein modified formaffects cotreatment|decreases expression 19789217
C088658 zoledronic acid zoledronic acid results in decreased prenylation of RAP1A proteindecreases prenylation 16675582
19442620
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.158875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6219490988
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.1619715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.1420200999
MESH:D000230 Adenocarcinoma Doxorubicin 4.1917418594
MESH:D000230 Adenocarcinoma Estradiol 4.1911473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5616712894 17306315
MESH:D000419 Albuminuria Doxorubicin 10.3821441931
MESH:D000419 Albuminuria Raloxifene 10.3817308373 17451421
MESH:D000544 Alzheimer Disease Nitric Oxide 4.4117556102
MESH:D000544 Alzheimer Disease Raloxifene 4.4115800139
MESH:D000550 Amblyopia Valproic Acid 4.8917688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.3117497229
MESH:D001284 Atrophy fulvestrant 4.5211514358
MESH:D001321 Autistic Disorder Valproic Acid 2.0418558336 18177632 18985861 17507914 18316065 18940202 19460635 17157402 15238991 17688650 20603192 16609825 19232924 18396377 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 2.9017594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.188888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3514601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.6417312309 19442620 15867366 11697798 16778634 16121404
MESH:D001862 Bone Resorption zoledronic acid 4.4018404659 18496637 15845617 8053405 11869084 16769263
MESH:D001930 Brain Injuries Raloxifene 4.1416580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.5217150277
MESH:D001943 Breast Neoplasms Doxorubicin 3.5416826403 16322301 19526202 15939500 15668708 15567936 17983394 16264153 17369602 16096432 18382427 15136595 11325840 18628466 18234424 16935488 16115903 18695136 15994142 15634643 15993339 16595493 15692762 17426702
MESH:D001943 Breast Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 3.5415528975
MESH:D001943 Breast Neoplasms Estradiol 3.5412948864 17018787 16675129 19861407 17261762 17289903 14630087 18497071
MESH:D001943 Breast Neoplasms fulvestrant 3.5418984771
MESH:D001943 Breast Neoplasms Nitric Oxide 3.5415631943
MESH:D001943 Breast Neoplasms Raloxifene 3.5416912660 15572757 16837676 17440819 17595753 17261762 15758505 17242785 17952589 17893378 15775269 17049068
MESH:D001943 Breast Neoplasms zoledronic acid 3.5418695136 16096432
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4616051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.0916705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.0918059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0916924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.0915276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.4219233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.441485588 16201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.4418507039
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.466189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4618572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7817572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.3117928571 16269455 16952015 15792986 17007740 16364871 17382496 16109756 16278810 17131338 16612575 15811867 17974986 17329180 16455267 16731534 17308081 18627295 15476868 17351982 17924179 16651473 17519947 15505089 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8316243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2115775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.856135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.8518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.8520056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D002779 Cholestasis Nitric Oxide 4.2016919318
MESH:D003072 Cognition Disorders Raloxifene 4.2915800139
MESH:D003110 Colonic Neoplasms arsenite 2.5315037631
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003327 Coronary Disease fluvastatin 4.5916142594
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.8816575769 17688650 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6918551238
MESH:D015140 Dementia, Vascular Nitric Oxide 5.6217556102
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8817474826
MESH:D003928 Diabetic Nephropathies Estradiol 8.0719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.0717308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.6917416283
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.691733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 3.4218602426
MESH:D004421 Dystonia Valproic Acid 3.741851702
MESH:D004487 Edema bisindolylmaleimide I 6.618273558
MESH:D004487 Edema Raloxifene 6.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.6815845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 11.3319148513
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.3317359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.3319148513 11473722 18566989
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8118037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.823659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.316426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.723659116
MESH:D005234 Fatty Liver arsenite 11.5618296743
MESH:D005234 Fatty Liver Raloxifene 11.5617473493
MESH:D005234 Fatty Liver Valproic Acid 11.5614986274 19224547
MESH:D005264 Femoral Fractures zoledronic acid 5.4916234978
MESH:D005315 Fetal Diseases Valproic Acid 4.5416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.818888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2519069698
MESH:D005355 Fibrosis arsenite 3.7418296743
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005909 Glioblastoma Doxorubicin 3.1317150277
MESH:D006261 Headache Nitric Oxide 4.8311284996 11554966
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3015692506
MESH:D006331 Heart Diseases Doxorubicin 7.0618006777 16244371 16495754 16707910 16244372 18674790 17875725 12587719 16879835 16144979 14766674 17888722 16330681
MESH:D006331 Heart Diseases Raloxifene 7.0611110106
MESH:D006333 Heart Failure Doxorubicin 3.1317481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6015692506
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease Doxorubicin 6.5415147373 17606976 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 6.5412676792
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5317688650
MESH:D006930 Hyperalgesia zoledronic acid 3.9816769263
MESH:D006934 Hypercalcemia zoledronic acid 4.7418089816 19622757
MESH:D006940 Hyperemia Nitric Oxide 5.2711156591
MESH:D006973 Hypertension Raloxifene 2.7417577099 15787275
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2916612254
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.1815838368
MESH:D006996 Hypocalcemia zoledronic acid 5.8512669777
MESH:D007248 Infertility, Male fulvestrant 6.3511514358
MESH:D007248 Infertility, Male sodium arsenite 6.3512646999 15346721
MESH:D007249 Inflammation bisindolylmaleimide I 3.728273558
MESH:D007333 Insulin Resistance Estradiol 2.7516627594 16393666
MESH:D007410 Intestinal Diseases N-(3-(aminomethyl)benzyl)acetamidine 9.8511713966
MESH:D007410 Intestinal Diseases Nitric Oxide 9.8510210152 11713966 11574821
MESH:D007674 Kidney Diseases Doxorubicin 9.0015699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 9.0015618244
MESH:D007674 Kidney Diseases sodium arsenite 9.0020008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8516707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.4616705839
MESH:D007680 Kidney Neoplasms Estradiol 6.4615610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7016316344
MESH:D007889 Leiomyoma Raloxifene 4.1816973256
MESH:D007896 Leishmaniasis Nitric Oxide 4.3717218153
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.6312970779
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.4718089816
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0916294345 17596541
MESH:D008103 Liver Cirrhosis arsenite 3.2318296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4814659978 14716833
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.177678174
MESH:D008113 Liver Neoplasms sodium arsenite 4.1716712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.366135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.3617085340 16842330
MESH:D008171 Lung Diseases sodium arsenite 2.9519095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9217228818
MESH:D055370 Lung Injury Nitric Oxide 4.3911395602
MESH:D008175 Lung Neoplasms arsenite 4.6316809336
MESH:D008175 Lung Neoplasms Doxorubicin 4.6317418594 6189445
MESH:D008175 Lung Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 4.6315528975
MESH:D008175 Lung Neoplasms sodium arsenite 4.6316712894 19931552 17077188 15276417 17306315
MESH:D008223 Lymphoma Doxorubicin 7.2416098063
MESH:D008223 Lymphoma Nitric Oxide 7.2416166326
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.8715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8711807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 8.8717312309
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D008545 Melanoma Doxorubicin 3.2616827129
MESH:D008545 Melanoma sodium arsenite 3.2616487513 19082730
MESH:D008654 Mesothelioma Doxorubicin 9.8717638057
MESH:D008654 Mesothelioma risedronic acid 9.8716675582
MESH:D008654 Mesothelioma zoledronic acid 9.8716675582
MESH:D008881 Migraine Disorders Nitric Oxide 7.1411701602
MESH:D008881 Migraine Disorders Valproic Acid 7.1418765137 18803445
MESH:D020326 Migraine without Aura Nitric Oxide 4.7914659530 11304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1915792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2115863610
MESH:D052016 Mucositis Doxorubicin 4.4517415656
MESH:D009101 Multiple Myeloma fluvastatin 11.0716996129
MESH:D009101 Multiple Myeloma Raloxifene 11.0716497877
MESH:D009101 Multiple Myeloma zoledronic acid 11.0719621390 18089719 16996129
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.728888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9617596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.8119429709 15857846
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0216810080
MESH:D009232 Myxoma Raloxifene 5.2116343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.527678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8018259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.8017312309 15867366 19139120
MESH:D009369 Neoplasms sodium arsenite 2.3411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009389 Neovascularization, Pathologic arsenite 9.0215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.0217289903
MESH:D009401 Nephrosis Doxorubicin 4.4416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7216889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 3.3311399458 16427766
MESH:D009436 Neural Tube Defects sodium arsenite 6.6012854658
MESH:D009436 Neural Tube Defects Valproic Acid 6.6016359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1416049721
MESH:D010014 Osteolysis zoledronic acid 5.0315867366
MESH:D010024 Osteoporosis Calcium 15.3817882678
MESH:D010024 Osteoporosis Raloxifene 15.3819059307 17882678 15775268
MESH:D010024 Osteoporosis risedronic acid 15.3817882678
MESH:D010024 Osteoporosis zoledronic acid 15.3817882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9215579764 17823083 15758505 17893378
MESH:D012516 Osteosarcoma Doxorubicin 3.8515930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10.4716211241
MESH:D010051 Ovarian Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 10.4715528975
MESH:D010051 Ovarian Neoplasms Estradiol 10.4719401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.4717306315 15276417
MESH:D010146 Pain zoledronic acid 3.6716475674
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8117638057
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.9918573544
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.4920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9118437689 16868541 16729912 15897917 16888761 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9116220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9116039940
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.9112438248 19103299
MESH:D019310 Pseudolymphoma Valproic Acid 4.1912752131 11422049
MESH:D011693 Purpura Raloxifene 5.2115770314
MESH:D051437 Renal Insufficiency Doxorubicin 3.8917922066
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8619155313
MESH:D012509 Sarcoma Doxorubicin 3.7016767912 17710206 17203757 18313854 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.5614601052 16326096
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.5616121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4517846226
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.129673227
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.1818551238
MESH:D012640 Seizures Valproic Acid 5.1811738929 11044598 17978042 16876388 15475178 1511512 14763951 3137016
MESH:D012878 Skin Neoplasms Doxorubicin 5.3815692506
MESH:D012878 Skin Neoplasms sodium arsenite 5.3818572023 19524636
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2317203757 15625365 16767912
MESH:D016135 Spinal Dysraphism sodium arsenite 8.6812854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1912833885
MESH:D013276 Stomach Ulcer Nitric Oxide 3.9015138204
MESH:D020521 Stroke Raloxifene 3.5616837676
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 7.1216940797
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.1217909728 16010429
MESH:D013978 Tibial Fractures Estradiol 12.5619048282
MESH:D013978 Tibial Fractures Raloxifene 12.5619048282
MESH:D014178 Translocation, Genetic Valproic Acid 4.8917262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.183119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.8116049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.8117653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.8117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.8116712894 17306315 11723127 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.318888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9810091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.8616837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8917678736 16364871 17334414 17638931
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2116343187
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:13552 Integrin cell surface interactions
KEGG:04670 Leukocyte transendothelial migration
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04972 Pancreatic secretion
KEGG:05211 Renal cell carcinoma
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34217
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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