AutismKB 2.0

Annotation Detail for ENPP5


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Basic Information Top
Gene Symbol:ENPP5 ( KIAA0879 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
Band: 6p21.1
Quick LinksEntrez ID:59084; OMIM: NA; Uniprot ID:ENPP5_HUMAN; ENSEMBL ID: ENSG00000112796; HGNC ID: 13717
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ENPP5 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENPP5 mRNAaffects cotreatment|increases expression 18164116
C004541 biochanin A biochanin A results in decreased expression of ENPP5 mRNAdecreases expression 12111696
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ENPP5 mRNAdecreases expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENPP5 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENPP5 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of ENPP5 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENPP5 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 7.316695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.3617162532 19052882 16434500 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816124888 3786805 16011737 10355542 16050911 15700767 16097048 15673190 16192424 16227642 18705752 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7110672840 17428255 16878318 19171122 20214788 16288022 19919837 17138121 19701751 17978847 20727157 20935162 18788625 17761372 18210153 17173139 19539802 16681979 18506893 20524982 16935385 18978308 19052882 20084675 16569478 16698587 18393292 20512989 3084413 18785209 17055752 19107877 20514400 18971187 16540662 16328049 20007298 16807293 19418558 19208518 16779866 3581430 20432363 11831363 18665156 17162532 18056438 18494052 19383236 18691550 19335982 21159647 16502159 19519916 20101231 16830150 19394651 10737359 19822196
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.017505956 21159647 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.0519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.0516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3317333356 17110522 15861022 17681005 16105132 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 15668235 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4618713872 11834606 2444490 17522070 19923254 11529661 16393943 19739265 15619225 17906064 19164858 16781746 19370779 12705907 12594235 11287661 17562736 11421492 12540782 14725611 12153990 10915739 16485898 14986274 11743745 18071297 14550746 10663392 11739529 19416960 16177239 12958197 16081117 16227642 12392966 11461765 15968718 16109766 19085960 10774834 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.462869522 15027814 4309450 6884620 3732212 7120509 7440962 6623471 16177239 3786805 16227642 15998439 21278145 19336974 17522070 7179309 15968718 11566570 19085960 10092053 10915739 9327722
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.4619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8615959796 12631006 12795759 61145 16239168 16045604 19224547 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8615345470
MESH:D005234 Fatty Liver pirinixic acid 20.8620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma biochanin A 4.6116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.3018467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3012621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.2718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0111408273 17174718 16239168 17334410 16943688 11903743 17157831 21278145 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0119638242 18407596 18522880 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5115650968 18187930 17869086 18420326 16116963 18395095 12649538 12741479 20821823 14716833 11481614 18481824 12445418 17976157 15893842 15052691 14620537 17565644 14512876 18279442 15370692 17631135 17698563 10355542 15925388 15959796 15931870 16192424 18054572 17721639 18472094 15362042 17481882 17766677 14724832 17708605 16136751 12632512 18006644 15123356 15057751 13678700 18705752 15818738 12389079 18166357 15730626 16033810 18395914 18205269 16015684 16097048 17823541 18263696 12666154 18156304 18376398 18418968 18210741 12609069 14716496 17761835 18251166 18317297 16248980 12445421 17714472 12958196 16638106 12667390 18412020 15996030 15338365 18339082 17805973 18429990 17922224 12586293 14748882 17944888 18472332 17900296 12632514 17525996 12898905 16011737 17557913 16027843 18277467 15876570 15673190 17640975 12546737
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Acetaminophen 6.7819460945 16610002 12969438 12587719 19014921 11587558 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7816246199 16964402 17285989 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7817034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 15.0921295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.0919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.0918644402 19254457 19499222 20583210 18977376 21071580 19426721 20434301 21278145 15885732 19294768 18648771 18754104 20101389 19690152 19551842 12112319 15175105 19833225 19255062 19256749 19642983 19812893 19996281 9163691 19427195 19638242 19073162 10737359 18978307 20137499 21167192 12771043 19850985 20492335 16942905 20452335 2422723 19090486 20501860 20405173 20118626 21047994 2862719
MESH:D008113 Liver Neoplasms pirinixic acid 15.0920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.3218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.3212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.3219539802 18093689 16267830 18775883 19009564 18079962 19004024 18544905 18308698 9362446 19126423 21159647 2563599 3124819 16842330 17942915 18282651 18164116 17854601 19519916 18253720 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.3212151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3120970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3111884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms biochanin A 4.6312111696
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27795
    • No data
    Releated disease ID Related disease Name
    PA445499Raynaud Disease
    Releated drug ID Related drug Name
    PA10333tadalafil
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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