AutismKB 2.0

Annotation Detail for RAP1GAP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAP1GAP ( KIAA0474,RAP1GA1,RAP1GAP1,RAP1GAPII,RAPGAP )
Gene Full Name: RAP1 GTPase activating protein
Band: 1p36.12
Quick LinksEntrez ID:5909; OMIM: 600278; Uniprot ID:RPGP1_HUMAN; ENSEMBL ID: ENSG00000076864; HGNC ID: 9858
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1767Immunologic deficiency syndrome
1848Embryoma
2106Pancreas cancer
Desease Name
plasma levels of liver enzymes
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of RAP1GAP mRNAdecreases expression 16982809
D001554 Benzene Benzene results in decreased expression of RAP1GAP mRNAdecreases expression 17905399
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RAP1GAP mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RAP1GAP mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of RAP1GAP mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased methylation of RAP1GAP promoterdecreases methylation 19147557
C014347 decitabine decitabine results in increased expression of RAP1GAP mRNAincreases expression 19147557
C014347 decitabine decitabine results in increased expression of RAP1GAP proteinincreases expression 19147557
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RAP1GAP mRNAaffects cotreatment|increases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RAP1GAP mRNAincreases expression 15766595
D004958 Estradiol Estradiol affects the expression of RAP1GAP mRNAaffects expression 15598610
C511689 (N)-methanocarba-2MeSADP RAP1GAP protein inhibits the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
C089730 rosiglitazone rosiglitazone results in decreased expression of RAP1GAP mRNAdecreases expression 16982809
C025462 sulindac sulfide sulindac sulfide results in increased expression of RAP1GAP mRNAincreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RAP1GAP mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000236 Adenoma Benzo(a)pyrene 11.476695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.4719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.4710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4517162532 19052882 17620307 19061943 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D000544 Alzheimer Disease rosiglitazone 4.7819621015
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7818759972
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000741 Anemia, Aplastic Benzene 4.4311369114 17661222 14761424
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001855 Bone Marrow Diseases Benzene 5.3616183116
MESH:D001943 Breast Neoplasms Benzene 3.8211921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.8220146248 17474063
MESH:D001943 Breast Neoplasms decitabine 3.8219208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.8217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.8215324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.8217289903 17261762 19861407 12948864 17018787 16675129 14630087 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7017055752 3581430 18978308 20432363 16830150 16681979 16569478 10737359 16878318 18665156 16502159 19383236 19208518 19052882 20727157 20935162 19919837 18785209 18788625 19394651 19701751 19418558 16328049 20101231 16698587 19107877 20214788 18971187 16288022 20084675 17173139 11831363 20514400 19822196 17978847 20007298 16540662 18210153 16935385 17162532 10672840 20512989 17138121 19335982 19171122 19519916 18506893 16807293 17761372 20524982 18056438 18691550 16779866 17428255 19539802 21159647 3084413 18494052 18393292
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4712391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002386 Cataract Am 580 4.3917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.482727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4818566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 8697196 16354765 12621046 15668235
MESH:D003092 Colitis Am 580 5.0617035595
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 2.7015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7020055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6516002989 12952375
MESH:D003872 Dermatitis Benzene 4.8715902427
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3717446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.2812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema rosiglitazone 7.2412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.7216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 7.7219148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.6919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.6920387270 21071580
MESH:D005234 Fatty Liver rosiglitazone 13.6919196556
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016513791 16611131 16002989 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006402 Hematologic Diseases Benzene 4.7416183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia rosiglitazone 3.9812083418
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5414722030 12960047
MESH:D006973 Hypertension Benzene 8.7817940673
MESH:D006973 Hypertension Cyclosporine 8.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7818850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.6816002989
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007248 Infertility, Male decitabine 3.2517581917
MESH:D007249 Inflammation Diethylnitrosamine 8.6118785209
MESH:D007249 Inflammation rosiglitazone 8.6112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.8016627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 7.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.088314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.8412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.8415003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 12.8415610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D007938 Leukemia Benzene 6.7817119257 15935818 18335105 14694614
MESH:D007938 Leukemia decitabine 6.7819235587 18980019
MESH:D007951 Leukemia, Myeloid Benzene 10.0617506065
MESH:D007951 Leukemia, Myeloid decitabine 10.0617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.2419478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.2418206229 19010910 19387464 18704418 17679729 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718665156 18407596 18522880 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.5817347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5620195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.5619389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5620405173 19638242 9163691 21278145 20434301 20452335 19850985 18978307 19427195 20583210 19073162 15175105 2422723 19294768 19551842 19499222 19256749 20137499 18754104 21071580 20492335 20101389 16942905 12771043 10737359 19812893 21047994 12112319 19090486 18977376 20501860 19254457 19690152 20118626 18644402 19255062 19833225 19642983 15885732 2862719 18648771 19996281 19426721 21167192
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.5615890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5616984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.5812562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.5818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5819519916 3124819 19009564 17174075 18079962 2563599 16267830 17942915 16842330 19126423 18775883 19004024 18544905 17854601 19539802 18164116 18308698 18253720 18282651 18093689 9362446 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5812151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9414698565
MESH:D008175 Lung Neoplasms Benzene 4.9212562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.926695378 18816296 20064080 18569708 17053015 20464547 20869020 18520028 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9220970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9219555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Benzene 13.0217119257 17584886
MESH:D008223 Lymphoma decitabine 13.0219470736
MESH:D008223 Lymphoma Diethylstilbestrol 13.0215700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.5612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 10.4411921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.4411807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.4416827153
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma marker/mechanism 19147557
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4417261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009101 Multiple Myeloma Benzene 7.7717119195
MESH:D009101 Multiple Myeloma decitabine 7.7718172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4319010910 18608210 16882708 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5711141357
MESH:D009369 Neoplasms decitabine 8.5717925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 8.5715313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.9511399458
MESH:D009421 Nervous System Malformations Estradiol 16.9516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9514600291
MESH:D009436 Neural Tube Defects Benzene 3.7215643154
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases Benzene 4.2615576619 15612468 17178637 15913788 17479406 17119257 15727169 16737584 15935809
MESH:D010051 Ovarian Neoplasms Benzene 8.1312562636
MESH:D010051 Ovarian Neoplasms decitabine 8.1319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 8.1319401270
MESH:D010190 Pancreatic Neoplasms decitabine 5.4519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4516540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7715687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.9617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9611896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5415846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.8516002989 16709447
MESH:D013274 Stomach Neoplasms Benzene 4.8112562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.812093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.8119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8118456281
MESH:D013953 Thymus Neoplasms Benzene 5.0710850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.497505956
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5617053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.5617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.5617306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Benzene 16.8612562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 16.8615809267 16690809
MESH:D014594 Uterine Neoplasms sulindac sulfide 16.8618645019
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34220
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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