AutismKB 2.0

Annotation Detail for RARRES3


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Basic Information Top
Gene Symbol:RARRES3 ( HRASLS4,MGC8906,PLA1/2-3,RIG1,TIG3 )
Gene Full Name: retinoic acid receptor responder (tazarotene induced) 3
Band: 11q12.3
Quick LinksEntrez ID:5920; OMIM: 605092; Uniprot ID:TIG3_HUMAN; ENSEMBL ID: ENSG00000133321; HGNC ID: 9869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of RARRES3 mRNAincreases expression 17034753
C041819 4-oxoretinol 4-oxoretinol results in increased expression of RARRES3 mRNAincreases expression 17034753
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RARRES3 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of RARRES3 mRNAincreases expression 17034753
C004984 apocarotenal apocarotenal results in decreased expression of RARRES3 mRNAdecreases expression 17034753
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RARRES3 mRNAaffects expression 20382639
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNAaffects cotreatment|decreases expression 12634122
D016572 Cyclosporine Cyclosporine results in increased expression of RARRES3 mRNAincreases expression 20106945
D019833 Genistein Genistein results in increased expression of RARRES3 mRNAincreases expression 15256057
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNAaffects cotreatment|decreases expression 12634122
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of RARRES3 mRNAdecreases expression 12634122
C009277 sodium arsenate sodium arsenate results in decreased expression of RARRES3 mRNAdecreases expression 12727804
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite sodium arsenite results in decreased expression of RARRES3 mRNAdecreases expression 12727804
12634122
D014212 Tretinoin Tretinoin results in increased expression of RARRES3 mRNAincreases expression 16054129
17218384
17034753
D014801 Vitamin A Vitamin A results in increased expression of RARRES3 mRNAincreases expression 17034753
D014810 Vitamin E Vitamin E results in increased expression of RARRES3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 4.8210992263
MESH:D000230 Adenocarcinoma Genistein 2.4711473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000740 Anemia Vitamin A 4.4816960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.7616960172
MESH:D001169 Arthritis, Experimental Tretinoin 3.0516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 5.1716456186
MESH:D001249 Asthma Vitamin A 5.1716732791
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5716197459 16206674
MESH:D001943 Breast Neoplasms alitretinoin 2.0616344269
MESH:D001943 Breast Neoplasms Genistein 2.0617200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tretinoin 2.0616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.9016813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.9017377406 17426644
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.5521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.5516924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5515276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.551917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6516051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 3.2716332659
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.8220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.8212371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 15.822727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.8219524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.4516153327
MESH:D002779 Cholestasis Cyclosporine 8.1919486331
MESH:D002779 Cholestasis Vitamin A 8.1916175620
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tretinoin 6.289407595
MESH:D002972 Cleft Palate Vitamin A 6.2816054864
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms Genistein 4.1217182828
MESH:D003110 Colonic Neoplasms Vitamin A 4.1217219422 16267017
MESH:D019465 Craniofacial Abnormalities lead acetate 7.3519769572
MESH:D019465 Craniofacial Abnormalities sodium arsenate 7.3510525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.358800419 9211117 17551590 16925845 9125849 9224671 9142499 14991402 9664655 10589399
MESH:D019465 Craniofacial Abnormalities Vitamin A 7.3510992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.3519769572
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4916506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4816647724
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 2.9918186108
MESH:D015352 Dry Eye Syndromes Vitamin A 5.7716146918
MESH:C538011 Eales disease Vitamin A 13.039068938
MESH:C538011 Eales disease Vitamin E 13.039068938
MESH:D004480 Ectromelia Vitamin A 5.7916054864
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.5516402032
MESH:D016889 Endometrial Neoplasms Genistein 7.4611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4616569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0620426865
MESH:D005124 Eye Abnormalities Tretinoin 3.5416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 2.8219224547
MESH:D005317 Fetal Growth Retardation lead acetate 5.3419769572
MESH:D005327 Fetal Resorption Vitamin A 5.3416054864
MESH:D005355 Fibrosis Cyclosporine 8.5612168785 12639820
MESH:D005355 Fibrosis Tretinoin 8.5617994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Genistein 7.1116598420
MESH:D005909 Glioblastoma Tretinoin 7.1117312396
MESH:D018149 Glucose Intolerance sodium arsenate 5.0419446573
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 11.2214991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 11.2216080930 10992263
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2216080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.1217436238 16292552 16490937 16877224 16863852 15707848
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.1216490937 16863852
MESH:D015658 HIV Infections Vitamin A 3.8016960176
MESH:D006679 HIV Seropositivity Vitamin A 5.5617209195
MESH:D006689 Hodgkin Disease sodium arsenite 3.1112676792
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006973 Hypertension Cyclosporine 2.0810903974
MESH:D006986 Hypervitaminosis A Vitamin A 6.1416054864
MESH:D007248 Infertility, Male sodium arsenite 2.9612646999 15346721
MESH:D007251 Influenza, Human Vitamin E 4.1916624496
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.7915955940
MESH:D007569 Jaw Abnormalities Tretinoin 3.8617551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6016144296
MESH:D007674 Kidney Diseases Cadmium Chloride 14.2816962696
MESH:D007674 Kidney Diseases Cyclosporine 14.2818776723 8314463 10903974
MESH:D007674 Kidney Diseases sodium arsenite 14.2820008137
MESH:D007674 Kidney Diseases Vitamin E 14.2812488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7012371664
MESH:D007938 Leukemia Genistein 6.3418980019 17468513
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219642359 19225113 16935935 9834237 17301526 17217047 17361223 17712046 17649720 17368321 17339181 16140955 16823087 16766008 17294898 15748426 19035177 16331271 19075265 19029980 17107899 12679006 16788101 17506722 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.409224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.4016054864
MESH:D008103 Liver Cirrhosis Vitamin A 3.8516256175
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0017823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0018397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 5.0016248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0016169303
MESH:D008107 Liver Diseases Vitamin A 3.1416175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.1216762690
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.6315890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms sodium arsenite 4.6315276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.298603461
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 6.2917113696
MESH:D008171 Lung Diseases sodium arsenite 12.2919095001
MESH:D008171 Lung Diseases Vitamin A 12.2916863852
MESH:D008171 Lung Diseases Vitamin E 12.2916863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8814755239
MESH:D008175 Lung Neoplasms alitretinoin 4.8816413115
MESH:D008175 Lung Neoplasms sodium arsenite 4.8816712894 15276417 17077188 17306315 19931552
MESH:D008175 Lung Neoplasms Vitamin E 4.8811062179
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9112929590 14578162
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma sodium arsenite 3.3219082730 16487513
MESH:D008545 Melanoma Tretinoin 3.3216752155
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.8517671175
MESH:D009101 Multiple Myeloma Vitamin A 4.0216374440
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.8118186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction Genistein 2.8417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6317141266
MESH:D009369 Neoplasms alitretinoin 8.2916946489
MESH:D009369 Neoplasms sodium arsenite 8.2911559025
MESH:D009369 Neoplasms Tretinoin 8.2916946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6320056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Genistein 9.6816427766
MESH:D009421 Nervous System Malformations Tretinoin 9.689125849
MESH:D009436 Neural Tube Defects sodium arsenate 17.1910525206 18186108 19446573 11749123
MESH:D009436 Neural Tube Defects sodium arsenite 17.1912854658
MESH:D009436 Neural Tube Defects Tretinoin 17.199142499
MESH:D009436 Neural Tube Defects Vitamin A 17.1917400914
MESH:D010024 Osteoporosis Genistein 3.2219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0416169203
MESH:D010051 Ovarian Neoplasms Genistein 7.8519005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.8517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8516936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4515976015
MESH:D017499 Porokeratosis alitretinoin 5.9816144296
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011471 Prostatic Neoplasms Genistein 2.6315256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6316039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6315084515
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.7716877224
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012871 Skin Diseases Vitamin A 5.2318709164
MESH:D012871 Skin Diseases Vitamin E 5.2318709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.7318572023 19524636
MESH:D012878 Skin Neoplasms Tretinoin 5.7316467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.4816517955
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4916452187 11723127 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.2811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.2816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D014802 Vitamin A Deficiency Vitamin A 5.2416175781 16146918 16960172
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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