AutismKB 2.0

Annotation Detail for HIVEP3


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Basic Information Top
Gene Symbol:HIVEP3 ( FLJ16752,KBP-1,KBP1,KIAA1555,KRC,SHN3,Schnurri-3,ZAS3,ZNF40C )
Gene Full Name: human immunodeficiency virus type I enhancer binding protein 3
Band: 1p34.2
Quick LinksEntrez ID:59269; OMIM: 606649; Uniprot ID:ZEP3_HUMAN; ENSEMBL ID: ENSG00000127124; HGNC ID: 13561
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HIVEP3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HIVEP3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HIVEP3 mRNAdecreases expression 18648102
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of HIVEP3 mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of HIVEP3 mRNA]decreases reaction|increases expression 12205029
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HIVEP3 mRNAaffects expression 17484886
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of HIVEP3 mRNAaffects expression 16962184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016050911 15673190 3786805 15721981 10355542 15700767 16192424 16097048 18705752 16227642 16124888 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.907296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.9018788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.366135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.367505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111298694 18759878 2524372 8156756 14531868 12868966 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.8618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.8618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.8618692083 9022650 18289764 7440962 6482804 8291058 11289319 18648102 6679447 9653073 1440618 9328219 16192314
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.8610915739 16177239 6623471 2869522 4309450 7440962 19336974 9327722 10092053 17522070 15027814 16227642 11566570 21278145 6884620 15968718 7179309 19085960 3786805 15998439 3732212 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4916045604 17595544 15959796 61145 12631006 19224547 12795759 16239168
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0220067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.526705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.5219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 18606429 8697196 16959395 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.006582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9616221502 16943688 16239168 11408273 17157831 17334410 11903743 17174718 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3613678700 16015684 18205269 18472332 15123356 15730626 17631135 12445418 15876570 17869086 18317297 12586293 12445421 14748882 16192424 18210741 17640975 16136751 12958196 16248980 17976157 12666154 12667390 14620537 17525996 15931870 17766677 17922224 16011737 14716496 18418968 18395914 12632512 15370692 12741479 17708605 18156304 18006644 18263696 17823541 14716833 15673190 18429990 17557913 18339082 14512876 16116963 15338365 16027843 12632514 15052691 17761835 18279442 12898905 15959796 18054572 17721639 15925388 18187930 12546737 10355542 15818738 15893842 17805973 17565644 16638106 15650968 18412020 15996030 12649538 18395095 18472094 12609069 17714472 15362042 12389079 11481614 18251166 16097048 17698563 18166357 17481882 15057751 18376398 20821823 18277467 16033810 14724832 17900296 18481824 17944888 18705752 18420326
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1415720792 17285989 15830285 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.977678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.652876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.65598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.6512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.6512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009041 Motion Sickness Dextroamphetamine 6.041613127
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.9012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.9016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.906482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11222880 11399792
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.898074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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