AutismKB 2.0

Annotation Detail for ACE2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACE2 ( ACEH,DKFZp434A014 )
Gene Full Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Band: Xp22.2
Quick LinksEntrez ID:59272; OMIM: 300335; Uniprot ID:ACE2_HUMAN; ENSEMBL ID: ENSG00000130234; HGNC ID: 13557
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
hsa04614Renin-angiotensin system
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1834Sarcoidosis
2032Kidney disease
2091Hypertension
2107Proteinuria
2180Coronavirus infection
Desease Name
Acute Coronary Syndrome
blood pressure, arterial
CARDIOVASCULAR
left ventricular hypertrophy
PHARMACOGENOMIC
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNAaffects cotreatment|decreases expression 17639512
C081309 irbesartan ACE2 gene polymorphism affects the susceptibility to irbesartanaffects response to substance 11593098
D019808 Losartan Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]decreases expression|decreases reaction 16176966
D019808 Losartan Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]decreases expression|decreases reaction 16176966
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACE2 mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNAaffects cotreatment|decreases expression 17639512
C081489 valsartan valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]decreases expression|decreases reaction 16176966
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000419 Albuminuria Losartan 6.2212586211
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D050197 Atherosclerosis Losartan 4.6610821809
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.6216443354
MESH:D001943 Breast Neoplasms Quercetin 2.6218628248
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D006528 Carcinoma, Hepatocellular Quercetin 2.3012508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D006332 Cardiomegaly Losartan 12.7712586211 15969258
MESH:D006332 Cardiomegaly Quercetin 12.7719794523
MESH:D006332 Cardiomegaly valsartan 12.7719597038
MESH:D009202 Cardiomyopathies valsartan 4.6316247790
MESH:D002318 Cardiovascular Diseases valsartan 4.5111230374
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4619440933 17191121 15741050 19056647 16640504 11134977 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 6.0017323712
MESH:D003324 Coronary Artery Disease valsartan 3.9817719468
MESH:D003384 Coxsackievirus Infections valsartan 6.3120392896
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 9.7719496084
MESH:D003921 Diabetes Mellitus, Experimental valsartan 9.7711508273
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.1516506275
MESH:D003928 Diabetic Nephropathies valsartan 5.0811427623 18630688
MESH:C538011 Eales disease Ascorbic Acid 6.009068938
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005355 Fibrosis Quercetin 10.8619474275
MESH:D005355 Fibrosis valsartan 10.8616893502
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.9216928621
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 3.9016080930
MESH:D006333 Heart Failure Losartan 13.1910979640
MESH:D006333 Heart Failure pirinixic acid 13.1920558911
MESH:D006333 Heart Failure valsartan 13.1919027736
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 16221962 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5616863852 16490937
MESH:D006943 Hyperglycemia pirinixic acid 10.2720558911
MESH:D006943 Hyperglycemia Quercetin 10.2711834736 18262572
MESH:D006973 Hypertension marker/mechanism 15833808 17473847
MESH:D006973 Hypertension irbesartan 13.5015188945 15614026 12022239 18464745 15453913 11910301 13678427 14700505 11593098 12359989
MESH:D006973 Hypertension Losartan 13.5010090350 14597852 12586211 15969258 12512695
MESH:D006973 Hypertension Quercetin 13.5018356687
MESH:D006973 Hypertension valsartan 13.5018344623 10903974 20102058 12692753 16475468 18390891 11427623 12850387
MESH:D006974 Hypertension, Malignant valsartan 6.9311560862
MESH:D007249 Inflammation Losartan 4.2012586211
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Quercetin 7.2716962696
MESH:D007674 Kidney Diseases valsartan 7.2716893502 12164870 10903974
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D008106 Liver Cirrhosis, Experimental Losartan 5.3617900296 12445418 15573910
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.3612741479
MESH:D008106 Liver Cirrhosis, Experimental valsartan 5.3615504291 15619341 16872305
MESH:D008113 Liver Neoplasms pirinixic acid 4.9316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 4.9318980244
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 7.0618544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 7.0619519916
MESH:D008171 Lung Diseases Ascorbic Acid 4.1516863852
MESH:D008175 Lung Neoplasms Ascorbic Acid 3.0116401635
MESH:D008175 Lung Neoplasms Quercetin 3.0116280456
MESH:D008382 Marfan Syndrome Losartan 6.4919430350
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction Losartan 10.3312692751
MESH:D009203 Myocardial Infarction pirinixic acid 10.3319151258
MESH:D009203 Myocardial Infarction Quercetin 10.3319595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.2519207477
MESH:D009369 Neoplasms pirinixic acid 5.5117405874
MESH:D009369 Neoplasms Quercetin 5.5115185748
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009765 Obesity Ascorbic Acid 4.9617217161
MESH:D009765 Obesity pirinixic acid 4.9620558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5517292933 14715546
MESH:D011507 Proteinuria valsartan 5.2118344623 17664856 12164870
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.8514606601
MESH:D011658 Pulmonary Fibrosis valsartan 3.9117241526
MESH:D051437 Renal Insufficiency Losartan 5.9415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3816849425
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012871 Skin Diseases Ascorbic Acid 3.2718709164
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.2118726076
MESH:D020521 Stroke Ascorbic Acid 4.5516517955 16403987
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9016720314
MESH:D020257 Ventricular Remodeling valsartan 6.1619027736
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
KEGG:04614 Renin-angiotensin system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA425
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    PA136400566Severe Acute Respiratory Syndrome
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    PA164712368Angiotensin II antagonists and calcium channel blockers
    PA448499atenolol
    PA448780captopril
    PA449899hydrochlorothiazide
    PA450631nifedipine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00691 antagonist Uniretic Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00722 antagonist Zestoretic Tab 20/25mg Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved