AutismKB 2.0

Annotation Detail for RBBP5


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Basic Information Top
Gene Symbol:RBBP5 ( RBQ3,SWD1 )
Gene Full Name: retinoblastoma binding protein 5
Band: 1q32.1
Quick LinksEntrez ID:5929; OMIM: 600697; Uniprot ID:RBBP5_HUMAN; ENSEMBL ID: ENSG00000117222; HGNC ID: 9888
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RBBP5 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RBBP5 mRNAincreases expression 20064835
C007262 deoxynivalenol deoxynivalenol results in increased expression of RBBP5 mRNAincreases expression 19438726
C051890 irinotecan irinotecan metabolite results in decreased expression of RBBP5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan metabolite results in increased expression of RBBP5 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of RBBP5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of RBBP5 mRNAincreases expression 15956246
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of RBBP5 mRNAincreases expression 12634122
C004648 testosterone enanthate testosterone enanthate affects the expression of RBBP5 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.817505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.812727394
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D003110 Colonic Neoplasms irinotecan 2.6317287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 17159606 15273666 17454858 18509181 18259882 16303861
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2114531868 11906362 8970840 12868966 2524372 8156756 11298694 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318692083 8291058 16192314 9653073 6679447 7440962 9022650 18648102 1440618 9328219 6482804 18289764 11289319
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5816530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 5.2515173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1321137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.711399818 6587162 598648 3712494
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18520028 18569708 20135361 6695378 20869020 18816296 20064080 17053015
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.3517671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D052016 Mucositis irinotecan 5.4717159606
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.273581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.2718259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009447 Neuroblastoma irinotecan 3.628761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.612093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.6115723263
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 3712494 6582329 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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