AutismKB 2.0

Annotation Detail for PLEKHA2


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Basic Information Top
Gene Symbol:PLEKHA2 ( FLJ25921,TAPP2 )
Gene Full Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Band: 8p11.22
Quick LinksEntrez ID:59339; OMIM: 607773; Uniprot ID:PKHA2_HUMAN; ENSEMBL ID: ENSG00000169499; HGNC ID: 14336
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200098Class I PI3K signaling events
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLEKHA2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLEKHA2 mRNAdecreases expression 19150397
20018196
20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLEKHA2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of PLEKHA2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PLEKHA2 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of PLEKHA2 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLEKHA2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PLEKHA2 mRNAincreases expression 17942748
C041786 palm oil palm oil results in decreased expression of PLEKHA2 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PLEKHA2 mRNAdecreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of PLEKHA2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9911237771
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.9919189210 19244106 15565566 16818667 11161223 17242785 19221464 21138602 19189212 19059307 20859285 20390343 19200415 19289846 18855134 16873071 18351453 16273361 15668708 18984771 21152245 18425577 20135344 16202921 20544844 19288272 17440819 19487384 17893378 18821012 19084267 18997820 19115204 17049068 18629630 19142967 18815881 20065188 19011961 19066611 19155303 19103187 17261762 19410462 20005174
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.993786805 16050911 15673190 16124888 16227642 18705752 15700767 16192424 15721981 16097048 10355542 16011737
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0818788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0816924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8320419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8311237771
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D002779 Cholestasis Cyclosporine 14.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.0911677210 17681005 17333356 16105132 17110522 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 14.0919176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.086884620 11566570 3732212 16177239 7120509 9327722 10092053 17522070 3786805 19085960 19336974 21278145 7179309 15998439 15027814 15968718 2869522 4309450 10915739 7440962 6623471 16227642
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 16.5415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.5419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1519155303 16202921 20544844 17893378
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.2161145 12795759 16045604 12631006 19224547 15959796 17595544 16239168
MESH:D005234 Fatty Liver Cyclosporine 33.2119224547
MESH:D005234 Fatty Liver Dietary Fats 33.2118296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.2115345470
MESH:D005234 Fatty Liver pirinixic acid 33.2119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 33.2119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 16.1018705752
MESH:D005355 Fibrosis Cyclosporine 16.1012639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.1018296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Dietary Fats 5.3720412841
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7818625569
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9216239168 17157831 11408273 11903743 21278145 17174718 16943688 16221502 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5512649538 12586293 17823541 13678700 18166357 11481614 17557913 15730626 16116963 17761835 18317297 18339082 18481824 17900296 18395914 12632514 14716496 12609069 15931870 17640975 17944888 15959796 15650968 12667390 14512876 20821823 12445418 18418968 12389079 18420326 15893842 18205269 17698563 18395095 18054572 16033810 18006644 15362042 17805973 18263696 15925388 16011737 18412020 17708605 18376398 18187930 16638106 15052691 15370692 15876570 15818738 16192424 14724832 12958196 12898905 17525996 18472332 15996030 17869086 16097048 18705752 18156304 12546737 12632512 17481882 17766677 17922224 15123356 17714472 14716833 15057751 17721639 14748882 12445421 16136751 17631135 14620537 10355542 12666154 16027843 16015684 15673190 18277467 12741479 17565644 18429990 18251166 18279442 16248980 17976157 18472094 18210741 15338365
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16964402 16246199 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1719294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.1715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 11.1716684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7115583823 12014681
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4117053015 18816296 20464547 20135361 18520028 6695378 20869020 20064080 18569708
MESH:D008175 Lung Neoplasms Tamoxifen 2.4118625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7314580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009765 Obesity Dietary Fats 4.5619632207 18674790 21332399 20132043 17217161 20518802 18457598 16723640 11836018
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5316289102 18247401 12479363 16644109 15754350
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4410029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1917572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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