AutismKB 2.0

Annotation Detail for GNB4


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Basic Information Top
Gene Symbol:GNB4 ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 4
Band: 3q26.33
Quick LinksEntrez ID:59345; OMIM: 610863; Uniprot ID:GBB4_HUMAN; ENSEMBL ID: ENSG00000114450; HGNC ID: 20731
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Transmembrane transport of small molecules
Hemostasis
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P05730Endogenous cannabinoid signaling
P04386Histamine H2 receptor mediated signaling pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00048PI3 kinase pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GNB4 mRNAincreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GNB4 mRNAincreases expression 20713471
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNB4 mRNAaffects expression 16483693
D001464 Barium [GNB4 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB4 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB4 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D004041 Dietary Fats Dietary Fats results in increased expression of GNB4 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GNB4 mRNAaffects expression 17555576
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GNB4 mRNAincreases expression 20713471
C041786 palm oil palm oil results in increased expression of GNB4 mRNAincreases expression 18042831
D020849 Raloxifene Raloxifene results in increased expression of GNB4 mRNAincreases expression 19429434
D013629 Tamoxifen Tamoxifen results in increased expression of GNB4 mRNAincreases expression 19429434
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GNB4 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma Methylcholanthrene 3.5710545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000419 Albuminuria Raloxifene 4.7617308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.0311921183
MESH:D001943 Breast Neoplasms Dietary Fats 3.0320435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.0317474063
MESH:D001943 Breast Neoplasms Raloxifene 3.0317893378 17242785 17440819 15775269 17049068 16837676 16912660 17595753 15572757 17261762 15758505 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 3.0320859285 19084267 19410462 19115204 17261762 19011961 20005174 17893378 18997820 18351453 20544844 18815881 17440819 19221464 19289846 15565566 19244106 19142967 21152245 18855134 20390343 19189212 19066611 16202921 19103187 19189210 20065188 18629630 18984771 15668708 19288272 16273361 16873071 11161223 19487384 19155303 19059307 20135344 18821012 21138602 18425577 19200415 17049068 17242785 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0320435547
MESH:D002277 Carcinoma Methylcholanthrene 8.7110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9811677210 16105132 17110522 17681005 17333356 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 15668235 8697196 12621046 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D015179 Colorectal Neoplasms marker/mechanism 17892325
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4517451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.4519279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Raloxifene 7.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.3315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.3319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1319155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 20.0018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.0015345470
MESH:D005234 Fatty Liver Raloxifene 20.0017473493
MESH:D005234 Fatty Liver Tamoxifen 20.0014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1314633661 10962813
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 8697196 16959395 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Raloxifene 5.3917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 8.6820412841
MESH:D007249 Inflammation Tamoxifen 8.6819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6812200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1911836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5516984957
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.28598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2812151625
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.5310545420 9230183 6695378 16337739 11893704 7750092 21163286 20970405 20512841 1399818 17909032 15390079 16271038
MESH:D008175 Lung Neoplasms Tamoxifen 3.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 6.6311921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6319196722 16827153 11731420 19196723 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity Dietary Fats 2.3116723640 19632207 21332399 18674790 17217161 11836018 18457598 20132043 20518802
MESH:D010024 Osteoporosis Raloxifene 3.4717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3815758505 17893378 17823083 15579764
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3316220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013978 Tibial Fractures Raloxifene 5.4319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3916712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134864200
    • No data
    Releated disease ID Related disease Name
    PA443512Urinary Bladder Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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