AutismKB 2.0

Annotation Detail for RBMS1


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Basic Information Top
Gene Symbol:RBMS1 ( C2orf12,DKFZp564H0764,HCC-4,MGC15146,MGC3331,MGC70597,MGC97258,MGC97270,MGC97282,MGC99543,MSSP,MSSP-1,MSSP-2,MSSP-3,SCR2,YC1 )
Gene Full Name: RNA binding motif, single stranded interacting protein 1
Band: 2q24.2
Quick LinksEntrez ID:5937; OMIM: 602310; Uniprot ID:RBMS1_HUMAN; ENSEMBL ID: ENSG00000153250; HGNC ID: 9907
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
Desease Name
Type 2 diabetes
Amyotrophic lateral sclerosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RBMS1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of RBMS1 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RBMS1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBMS1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of RBMS1 mRNAincreases expression 20106945
C051890 irinotecan RBMS1 protein results in decreased susceptibility to irinotecandecreases response to substance 16734730
D008727 Methotrexate RBMS1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D011794 Quercetin Quercetin results in decreased expression of RBMS1 mRNAdecreases expression 15309432
D012643 Selenium Selenium results in decreased expression of RBMS1 mRNAdecreases expression 19244175
D012643 Selenium Selenium results in increased expression of RBMS1 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin affects the expression of RBMS1 mRNAaffects expression 16054129
D014810 Vitamin E Vitamin E results in decreased expression of RBMS1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.4412039119
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9018414634 16251483 12569548 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.9717286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9716292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7516197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0320146248 17474063
MESH:D001943 Breast Neoplasms Methotrexate 2.0316978400
MESH:D001943 Breast Neoplasms Quercetin 2.0318628248
MESH:D001943 Breast Neoplasms Tretinoin 2.0316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.773084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.7719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.771917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.7718922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.7716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D006332 Cardiomegaly Quercetin 3.3919794523
MESH:D002318 Cardiovascular Diseases Arsenic 3.5419152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4318022660 16973168
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Selenium 10.0917936198
MESH:D003092 Colitis Tretinoin 10.0917035595
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003110 Colonic Neoplasms irinotecan 4.1117287894 17725105
MESH:D003110 Colonic Neoplasms Quercetin 4.1117191121 15741050 19056647 11134977 16640504 17148506 19440933
MESH:D015179 Colorectal Neoplasms irinotecan 2.8317454858 15273666 18509181 18259882 16391804 17159606 16303861
MESH:D015179 Colorectal Neoplasms Quercetin 2.8318095365 18852136
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.0312039119 9562676
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.039224671 17551590 9211117 14991402 16925845 10589399 8800419 9664655 9125849 9142499
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.0319769572
MESH:D003550 Cystic Fibrosis Methotrexate 4.3719747007
MESH:D003882 Dermatomyositis Methotrexate 5.2920191521
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116485898 18071297 12594235 16081117 17522070 16177239 18713872 11834606 11421492 16109766 15619225 17906064 15968718 16227642 2444490 19416960 19370779 11743745 19164858 10663392 10774834 11529661 17562736 12153990 19923254 19739265 19420014 14550746 12392966 11287661 16393943 11739529 11461765 12958197 12540782 16781746 14725611 10915739 14986274 12705907 19085960
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005355 Fibrosis Cyclosporine 15.9112168785 12639820
MESH:D005355 Fibrosis Quercetin 15.9119474275
MESH:D005355 Fibrosis Tretinoin 15.9117994277
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Quercetin 7.5519804834
MESH:D005909 Glioblastoma Tretinoin 7.5517312396
MESH:D005910 Glioma Quercetin 3.1017643826
MESH:D006086 Graft vs Host Disease Methotrexate 5.3216518429
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5820471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.589664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5816080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia Quercetin 4.1618262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 8.999931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 8.9910903974
MESH:D006973 Hypertension Quercetin 8.9918356687
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007251 Influenza, Human Quercetin 19.9616624496
MESH:D007251 Influenza, Human Selenium 19.9616624496
MESH:D007251 Influenza, Human Vitamin E 19.9616624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 15.0815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.0818776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 15.0816962696
MESH:D007674 Kidney Diseases Vitamin E 15.0812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007805 Language Development Disorders Methotrexate 5.259562676
MESH:D007938 Leukemia Quercetin 6.6717468513
MESH:D007938 Leukemia Tretinoin 6.6717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0517339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.0517301526 16140955 17649720 17339181 16823087 19642359 19029980 16766008 17294898 16935935 19035177 15748426 9834237 19225113 16788101 17712046 12679006 16331271 17361223 17368321 16891316 17107899 19075265 17217047 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008103 Liver Cirrhosis Methotrexate 3.7714986274
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6812741479
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6816169303
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 11587558 19014921 16611625 12969438 16610002 19784758 12587719
MESH:D008107 Liver Diseases Arsenic 4.1711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 7.8416368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8420195826 21137059
MESH:D008113 Liver Neoplasms Quercetin 7.8418980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.1419519916
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2418516814
MESH:D008175 Lung Neoplasms Arsenic 5.0117976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0118816296 17053015 18569708 6695378 20064080 18520028 20464547 20135361 20869020
MESH:D008175 Lung Neoplasms Quercetin 5.0116280456
MESH:D008175 Lung Neoplasms Vitamin E 5.0111062179
MESH:D008223 Lymphoma Methotrexate 4.0517352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D052016 Mucositis irinotecan 13.2617159606
MESH:D052016 Mucositis Methotrexate 13.2617488658
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction Quercetin 3.0419595682
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9019207477
MESH:D009362 Neoplasm Metastasis irinotecan 3.2218259882
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6811141357
MESH:D009369 Neoplasms Quercetin 8.6815185748
MESH:D009369 Neoplasms Tretinoin 8.6816594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects Arsenic 7.7216620997
MESH:D009436 Neural Tube Defects Tretinoin 7.729142499
MESH:D009447 Neuroblastoma irinotecan 3.548761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.928761367
MESH:D020078 Neurogenic Inflammation Arsenic 11.1917056641
MESH:D020078 Neurogenic Inflammation Quercetin 11.1917929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3719495926
MESH:D010051 Ovarian Neoplasms Arsenic 8.2217306315
MESH:D010051 Ovarian Neoplasms Quercetin 8.2219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 8.2216936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5615976015
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.5212371664
MESH:D011230 Precancerous Conditions Quercetin 9.5219056647
MESH:D011471 Prostatic Neoplasms Arsenic 2.0816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Quercetin 2.0814715546 17292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011507 Proteinuria Arsenic 9.7821343184
MESH:D011507 Proteinuria Tretinoin 9.7816636307
MESH:D011565 Psoriasis Cyclosporine 6.0516882103
MESH:D011565 Psoriasis Methotrexate 6.0517410198
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D051437 Renal Insufficiency Methotrexate 4.8917352296
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012871 Skin Diseases Arsenic 5.1517548696 16353154 17453740 16759981 17938729 16702368 18709164 6392382 19834688 15952646 17050553
MESH:D012871 Skin Diseases Vitamin E 5.1518709164
MESH:D012878 Skin Neoplasms Arsenic 9.8717976673 17029826 17050553 15504454 16251483 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8719755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 9.8716467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4720155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 3.4715723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.4717261132
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013576 Syndactyly Methotrexate 5.209562676
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7018640142 15987713 19429237 17976673 17306315 11144890 19322015
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7017053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.7016720314
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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