AutismKB 2.0

Annotation Detail for RBP1


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Basic Information Top
Gene Symbol:RBP1 ( CRABP-I,CRBP,CRBP1,CRBPI,RBPC )
Gene Full Name: retinol binding protein 1, cellular
Band: 3q23
Quick LinksEntrez ID:5947; OMIM: 180260; Uniprot ID:RET1_HUMAN; ENSEMBL ID: ENSG00000114115,ENSG00000248478; HGNC ID: 9919
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200142Retinoic acid receptors-mediated signaling
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1781Rheumatoid arthritis
1934Cancer
2233Cirrhosis
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RBP1 mRNAaffects expression 21346803
C022776 2-bromopalmitate 2-bromopalmitate results in increased expression of RBP1 mRNAincreases expression 12576510
C054189 3,5-di-tert-butylchalcone 4'-carboxylic acid 3,5-di-tert-butylchalcone 4'-carboxylic acid results in increased expression of RBP1 mRNAincreases expression 7556191
C038864 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of RBP1 mRNAincreases expression 12576510
C520164 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of RBP1 mRNAincreases expression 12576510
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of RBP1 mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of RBP1 proteinaffects expression 16099942
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RBP1 proteinaffects expression 20106945
C096920 AGN 193109 AGN 193109 results in decreased expression of RBP1 mRNAdecreases expression 12576510
C430898 AGN 194204 AGN 194204 results in decreased expression of RBP1 mRNAdecreases expression 12576510
C068073 Am 580 Am 580 results in increased expression of RBP1 mRNAincreases expression 16982809
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RBP1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RBP1 mRNAincreases expression 20106945
D002104 Cadmium Cadmium results in increased expression of RBP1 mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of RBP1 mRNAincreases expression 17327699
D002118 Calcium Calcium affects the expression of RBP1 mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RBP1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of RBP1 proteindecreases expression 12889522
D003345 Corticosterone Corticosterone results in decreased expression of RBP1 mRNAdecreases expression 15755911
C030123 coumarin coumarin results in decreased expression of RBP1 mRNAdecreases expression 18480146
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA]decreases reaction|increases expression 18200517
D016572 Cyclosporine Cyclosporine results in decreased expression of RBP1 mRNAdecreases expression 20106945
C014347 decitabine decitabine promotes the reaction [Tretinoin results in increased expression of RBP1 mRNA]increases expression|increases reaction 17079450
C014347 decitabine decitabine results in decreased metabolism of RBP1 genedecreases metabolic processing 17079450
C014347 decitabine decitabine results in increased expression of RBP1 mRNAincreases expression 16367923
D002945 Cisplatin RBP1 protein results in increased susceptibility to Cisplatinincreases response to substance 16734730
D004041 Dietary Fats Dietary Fats results in increased expression of RBP1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RBP1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RBP1 mRNA]decreases reaction|increases expression 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of RBP1 mRNAdecreases expression 19371625
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RBP1 mRNAincreases expression 17011747
D004958 Estradiol Estradiol results in increased expression of RBP1 mRNAincreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of RBP1 mRNAincreases expression 11509816
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RBP1 mRNAdecreases expression 17161848
15834898
D004997 Ethinyl Estradiol Tretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RBP1 mRNA]decreases expression|decreases reaction 17161848
D015025 Zearalenone Zearalenone results in decreased expression of RBP1 mRNAdecreases expression 19371625
D005472 Fluorouracil Fluorouracil results in decreased expression of RBP1 proteindecreases expression 15352031
D005472 Fluorouracil RBP1 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D019833 Genistein Genistein results in decreased expression of RBP1 mRNAdecreases expression 19371625
C029424 hydrazine hydrazine results in increased expression of RBP1 proteinincreases expression 15370871
C007350 nitrofen nitrofen results in increased expression of RBP1 mRNAincreases expression 17270546
D017239 Paclitaxel RBP1 protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
C041786 palm oil palm oil results in increased expression of RBP1 mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of RBP1 mRNAdecreases expression 17681415
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RBP1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of RBP1 mRNAincreases expression 19270015
19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RBP1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of RBP1 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein inhibits the reaction [pirinixic acid results in increased expression of RBP1 mRNA]decreases reaction|increases expression 17950772
D011374 Progesterone [Progesterone results in increased activity of PGR protein] which results in increased expression of RBP1 mRNAincreases activity|increases expression 15845616
D012172 Retinaldehyde ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]affects binding|affects metabolic processing 10559215
D012176 Retinoids RBP1 protein affects the abundance of Retinoidsaffects abundance 16109390
C089730 rosiglitazone rosiglitazone results in increased expression of RBP1 mRNAincreases expression 16982809
C009277 sodium arsenate sodium arsenate results in decreased expression of RBP1 mRNAdecreases expression 16882884
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RBP1 mRNAdecreases expression 17035482
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RBP1 mRNAdecreases expression 16960034
11752688
D014212 Tretinoin decitabine promotes the reaction [Tretinoin results in increased expression of RBP1 mRNA]increases expression|increases reaction 17079450
D014212 Tretinoin Tretinoin promotes the reaction [HIST4H4 protein modified form binds to RBP1 gene]affects binding|increases reaction 17079450
D014212 Tretinoin Tretinoin promotes the reaction [RARB protein alternative form binds to RBP1 promoter]affects binding|increases reaction 17079450
D014212 Tretinoin Tretinoin results in increased expression of RBP1 mRNAincreases expression 17431108
17079450
16012519
7556191
16249480
D014212 Tretinoin Tretinoin results in increased expression of RBP1 mRNAincreases expression 16505366
16604517
D014212 Tretinoin Tretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RBP1 mRNA]decreases expression|decreases reaction 17161848
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNAincreases expression 17982090
18200517
C025643 vinclozolin vinclozolin affects the expression of RBP1 mRNAaffects expression 19015723
D014801 Vitamin A RBP1 protein results in increased uptake of Vitamin Aincreases uptake 16150442
D014801 Vitamin A Vitamin A results in increased expression of RBP1 mRNAincreases expression 16793012
D014801 Vitamin A Vitamin A affects the expression of RBP1 mRNAaffects expression 12576510
D014801 Vitamin A Vitamin A binds to and affects the transport of RBP1 proteinaffects binding|affects transport 16968212
D014810 Vitamin E Vitamin E results in increased expression of RBP1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.2217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.226195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2211752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.3910992263
MESH:D000138 Acidosis Ammonium Chloride 8.7218287403
MESH:D000138 Acidosis Ethanol 8.7211192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4017505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.4915814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 2.6318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 14.9620127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 14.9617638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 14.9611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 14.9614692618
MESH:D000230 Adenocarcinoma Fluorouracil 14.9617638652
MESH:D000230 Adenocarcinoma Genistein 14.9611473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.556695378
MESH:D000236 Adenoma Diethylnitrosamine 5.5510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.5318056438 16434500 17620307 17162532 19052882 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.5317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.5316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.5316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7815451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5417887948
MESH:D000505 Alopecia Tretinoin 3.1915955085
MESH:D000544 Alzheimer Disease Curcumin 4.0615590663
MESH:D000544 Alzheimer Disease rosiglitazone 4.0619621015
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9815469931
MESH:D000740 Anemia Fluorouracil 12.2615504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 12.2611748828
MESH:D000740 Anemia Vitamin A 12.2616960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.3416960172
MESH:D000799 Angioedema Acetaminophen 3.3110982225
MESH:D000853 Anophthalmos Ethanol 4.3015513904
MESH:D001008 Anxiety Disorders Ethanol 7.6111141031
MESH:D001008 Anxiety Disorders vinclozolin 7.6119015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5619183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.2015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.2011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.0716412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.2216807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2216292516
MESH:D001249 Asthma Tretinoin 4.5816456186
MESH:D001249 Asthma Vitamin A 4.5816732791
MESH:D050197 Atherosclerosis Cadmium 5.9515687053
MESH:D050197 Atherosclerosis Curcumin 5.9518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001327 Autoimmune Diseases Curcumin 3.9819761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.5412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.5416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.3514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0815867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8017868700
MESH:D001930 Brain Injuries Progesterone 3.7415380490 15845082 15665606
MESH:D002545 Brain Ischemia Curcumin 3.8116770732
MESH:D001932 Brain Neoplasms Curcumin 3.4817596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 13.0620146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 13.0618382427 19526202
MESH:D001943 Breast Neoplasms Curcumin 13.0619250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms decitabine 13.0618320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 13.0620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 13.0617474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 13.0615324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 13.0614630087 12948864 17261762 16675129 18497071 17018787 19861407 17289903
MESH:D001943 Breast Neoplasms Fluorouracil 13.0616595493 16557594 19217205 16110121 15136595 18357371 18608205
MESH:D001943 Breast Neoplasms Genistein 13.0616541309 16873071 17200150
MESH:D001943 Breast Neoplasms Paclitaxel 13.0618223236 16115903 18234424 18323546 11325840 15136595 16244791 16273361
MESH:D001943 Breast Neoplasms Progesterone 13.0616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Retinoids 13.0617491551 19340624 17368321
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 13.0620435547
MESH:D001943 Breast Neoplasms Tretinoin 13.0616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.2616813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.2617377406 17426644
MESH:D002056 Burns Ethanol 4.1416374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.2316097048 15673190 16011737 10355542 16124888 15700767 16192424 15721981 16050911 3786805 18705752 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.2316050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1316051944
MESH:D002277 Carcinoma Curcumin 11.5318593918
MESH:D002277 Carcinoma Fluorouracil 11.5317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.5316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 32.8516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 32.853084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 32.8512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 32.8518788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 32.8517982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 32.8518393292 3581430 16807293 19335982 19171122 16681979 19919837 18691550 17173139 18056438 18506893 18978308 20084675 18494052 19539802 20432363 19701751 16328049 20935162 19107877 3084413 19383236 11831363 16878318 17761372 16935385 17138121 20101231 20514400 17162532 19394651 16540662 16288022 20007298 18788625 16502159 10672840 19822196 19052882 19208518 18210153 20524982 18785209 20512989 17428255 16779866 17978847 19418558 19519916 10737359 17055752 20214788 21159647 18665156 16698587 16569478 20727157 18971187 16830150
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 32.8515948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 32.8516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 32.8515289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 32.8518930000 17088986 16332177 16799960 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 32.8516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 32.8516313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 32.8520007298 6705139 1701930 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 32.851917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.0716685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.0718414057
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.7518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 15.6620419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 15.6617066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Curcumin 15.6618462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 15.6619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 15.6617066447 18986760 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.6616051514 16096774
MESH:D006332 Cardiomegaly Ethanol 5.8019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8018670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 2.9316332659
MESH:D002386 Cataract Acetaminophen 10.5710977129
MESH:D002386 Cataract Am 580 10.5717460283
MESH:D002386 Cataract Tretinoin 10.5717460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 12.9817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.9812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.987505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.9818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.744080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0616129372
MESH:D015362 Child Nutrition Disorders Vitamin A 4.9416153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.8416835633
MESH:D002779 Cholestasis Cyclosporine 16.0019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.0017110522 16105132 17333356 11677210 15861022 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 16.0019176532
MESH:D002779 Cholestasis Vitamin A 16.0016175620
MESH:D002822 Choriocarcinoma Tretinoin 4.6216461808
MESH:D002971 Cleft Lip Ethanol 3.2915513904
MESH:D002972 Cleft Palate Ethanol 12.0815513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.0812621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 12.089407595
MESH:D002972 Cleft Palate Vitamin A 12.0816054864
MESH:D003092 Colitis Am 580 18.7117035595
MESH:D003092 Colitis Curcumin 18.7116804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 18.7117035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 18.7117991707 16474422 11698051 17936198 16782535 18023891 16867261 16804969 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.2417276891
MESH:D003103 Coloboma Curcumin 4.0718809619
MESH:D003110 Colonic Neoplasms Curcumin 9.7319359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 9.7317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 9.7317016597 18772588 17725105 16340194 17018589 15001691 17169374 16510598 17172411 17287894
MESH:D003110 Colonic Neoplasms Genistein 9.7317182828
MESH:D003110 Colonic Neoplasms Vitamin A 9.7316267017 17219422
MESH:D015179 Colorectal Neoplasms Cisplatin 4.3115273666
MESH:D015179 Colorectal Neoplasms decitabine 4.3118981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.3118949393 20501625 17016601 17695437 16303861 15289873 16282729 14970324 17594712 18448328 17401013 17094418 15148649 16524972 17255274 18802399 18288408 16391804 16331619 17454858 18383874 18509181
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.3118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.3818497527
MESH:D019465 Craniofacial Abnormalities Ethanol 10.5810194807 11198716 15513904 15451039 15451040 19302082 11873399
MESH:D019465 Craniofacial Abnormalities nitrofen 10.5811405365
MESH:D019465 Craniofacial Abnormalities sodium arsenate 10.5810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 10.5810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 10.5816925845 9142499 9211117 8800419 9224671 9125849 17551590 10589399 14991402 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin A 10.5810992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 10.5819769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.7016002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 9.7014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5018551238
MESH:D007644 Darier Disease Fluorouracil 4.2616733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1618249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.8617446233
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3216506275
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 15.1219647726
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 15.1218403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 15.1220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 15.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 15.1212642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 15.1217107852
MESH:D003928 Diabetic Nephropathies Curcumin 7.5618204486
MESH:D003928 Diabetic Nephropathies Estradiol 7.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9817187935
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 16099942
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.762444490 19085960 15619225 10915739 19420014 11287661 10774834 12153990 16485898 12540782 19164858 17906064 19923254 16177239 18713872 12705907 11743745 19739265 12392966 16081117 15968718 17522070 17562736 11529661 12594235 11834606 19370779 16227642 16393943 11421492 11739529 16781746 14550746 18071297 11461765 14986274 19416960 10663392 16109766 14725611 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.7610092053 19085960 7179309 7120509 19336974 3786805 2869522 3732212 15027814 6623471 11566570 17522070 21278145 15968718 6884620 4309450 15998439 10915739 16227642 7440962 9327722 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.7619107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 15.7611566570
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 15.7618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5619426721
MESH:D004362 Drug Toxicity Cisplatin 6.8512649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8511462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.2716146918
MESH:D004381 Duodenal Ulcer Curcumin 3.5517351913
MESH:D050171 Dyslipidemias Dietary Fats 3.0718367378
MESH:D004421 Dystonia Phenobarbital 3.521851702
MESH:C538011 Eales disease Vitamin A 11.339068938
MESH:C538011 Eales disease Vitamin E 11.339068938
MESH:D004480 Ectromelia Vitamin A 5.2816054864
MESH:D004487 Edema perfluorooctanoic acid 12.6417259670 12083418
MESH:D004487 Edema pirinixic acid 12.6412083418
MESH:D004487 Edema rosiglitazone 12.6412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.6412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.1518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.3817692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5819294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.1416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.1416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.8516804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 14.8518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 14.8511473722
MESH:D016889 Endometrial Neoplasms Tretinoin 14.8516569247
MESH:D004715 Endometriosis Progesterone 7.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.4110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.343922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.106401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.493659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5816302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.0516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.0516481741 15173087 17638652 15464296 16785472
MESH:D004938 Esophageal Neoplasms Ethanol 12.0516704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.0516481741 16337965 16785472 15173087 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 12.0516481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.509664655 16938888
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.4716968212
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.5312795759 17595544 12631006 15959796 16239168 19224547 61145 16045604
MESH:D005234 Fatty Liver Curcumin 40.5319297423
MESH:D005234 Fatty Liver Cyclosporine 40.5319224547
MESH:D005234 Fatty Liver Dietary Fats 40.5318296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 40.5320387270 21071580
MESH:D005234 Fatty Liver Ethanol 40.5318620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.5315345470
MESH:D005234 Fatty Liver pirinixic acid 40.5320131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 40.5319196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1317920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3216534752 15751030 16002989 16611131 16513791
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7716946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005327 Fetal Resorption Vitamin A 4.8316054864
MESH:D005355 Fibrosis Carbon Tetrachloride 33.6118705752
MESH:D005355 Fibrosis Curcumin 33.6118705752
MESH:D005355 Fibrosis Cyclosporine 33.6112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 33.6118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 33.6120067830
MESH:D005355 Fibrosis Tretinoin 33.6117994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 33.6117994277
MESH:D005756 Gastritis Acetaminophen 9.3416983495
MESH:D005756 Gastritis Ethanol 9.3415046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1818462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7616417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.4216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.698708960
MESH:D005909 Glioblastoma Curcumin 9.8717596214
MESH:D005909 Glioblastoma Genistein 9.8716598420
MESH:D005909 Glioblastoma Tretinoin 9.8717312396
MESH:D005910 Glioma Fluorouracil 2.6416145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.5919446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 25.3815102660 15464296
MESH:D006258 Head and Neck Neoplasms Curcumin 25.3818462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 25.3819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 25.3818337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Retinoids 25.3817368321
MESH:D006258 Head and Neck Neoplasms Tretinoin 25.3816096774
MESH:D034381 Hearing Loss Cisplatin 3.8519898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6216084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9815464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 22.4120471113
MESH:D006330 Heart Defects, Congenital nitrofen 22.4116080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 22.4110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 22.4114991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 22.4110992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 22.4116080930
MESH:D006333 Heart Failure pirinixic acid 2.2020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1019900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.483609246
MESH:D006529 Hepatomegaly Phenobarbital 16.4816109766
MESH:D006529 Hepatomegaly pirinixic acid 16.4818467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.4815340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5217701891
MESH:D006548 Hernia, Diaphragmatic nitrofen 8.5812904592 9476886 15578192 11051153 16863852 17245593 11057544 9473106 18280292 17618886 11329586 12547725 12021965 11588001 7576705 16080930 11409163 16473863 7520565 12505043 10898224 12194112 15756563 9575882 18958481 18280291 11584395 10898222 9859898 17270546 10541330 16490937 10370016 15088113 12759764 15707848 10646786 10370017 15185205 7760232 16292651 10359170 9698600 11076806 10693666 15764645 12407540 8863223 16720372 11685700 15793718 15136996 12746050
MESH:D006548 Hernia, Diaphragmatic Vitamin A 8.5816877224 16490937 16292552 16863852 15707848 17436238
MESH:D006548 Hernia, Diaphragmatic Vitamin E 8.5816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4915709030
MESH:D015658 HIV Infections Vitamin A 3.5316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.0717209195
MESH:D006689 Hodgkin Disease Cisplatin 3.1616170182 16200630
MESH:D019584 Hot Flashes Estradiol 8.2617088409
MESH:D019584 Hot Flashes Vitamin E 8.2614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5116354765 18606429 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 20.0516870215
MESH:D006930 Hyperalgesia Ethanol 20.0518783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 20.0512083418
MESH:D006930 Hyperalgesia rosiglitazone 20.0512083418
MESH:D006930 Hyperalgesia Tretinoin 20.0516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0016899240
MESH:D006937 Hypercholesterolemia Curcumin 7.6618704882
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0516778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1321332399
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9212960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.1910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5715338365
MESH:D006986 Hypervitaminosis A Vitamin A 5.6316054864
MESH:D007021 Hypospadias Diethylstilbestrol 9.5316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.5316569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8915869954
MESH:D007246 Infertility Diethylstilbestrol 3.8515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9812013081
MESH:D007248 Infertility, Male decitabine 9.1217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.1217937319
MESH:D007248 Infertility, Male vinclozolin 9.1216467254
MESH:D007249 Inflammation Curcumin 19.6718403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 19.6720412841
MESH:D007249 Inflammation Diethylnitrosamine 19.6718785209
MESH:D007249 Inflammation perfluorooctanoic acid 19.6712083418
MESH:D007249 Inflammation Progesterone 19.6715869954
MESH:D007249 Inflammation rosiglitazone 19.6712083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.6712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 5.8918200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 5.8918200517
MESH:D007251 Influenza, Human Vitamin E 3.6816624496
MESH:D007333 Insulin Resistance Dietary Fats 14.7211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.7216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 14.7216306350
MESH:D007333 Insulin Resistance rosiglitazone 14.7216306350
MESH:D007410 Intestinal Diseases Tretinoin 8.2817994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 8.2817994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.7610783313
MESH:D019586 Intracranial Hypertension Vitamin A 5.2815955940
MESH:D007569 Jaw Abnormalities Ethanol 14.4415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.4416580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.4417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9015604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.6015464296
MESH:D007674 Kidney Diseases Acetaminophen 23.9012587719 15629191
MESH:D007674 Kidney Diseases Cadmium 23.9016226777 16962696 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 23.9016962696
MESH:D007674 Kidney Diseases Cisplatin 23.9012231392 12649298 18289764 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 23.9018776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 23.9015618244
MESH:D007674 Kidney Diseases Vitamin E 23.9012488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.7816762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 18.7815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 18.7816985049
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 10.1016316344
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 10.1011231351
MESH:D007859 Learning Disorders Diethylstilbestrol 8.0817184923
MESH:D007859 Learning Disorders Ethanol 8.0815451040
MESH:D007889 Leiomyoma Curcumin 4.0818555241
MESH:D007938 Leukemia Curcumin 12.6318462866
MESH:D007938 Leukemia decitabine 12.6319235587 18980019
MESH:D007938 Leukemia Genistein 12.6317468513 18980019
MESH:D007938 Leukemia Tretinoin 12.6317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.7316106398
MESH:D007951 Leukemia, Myeloid decitabine 13.5018454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Retinoids 13.5016482212
MESH:D007951 Leukemia, Myeloid Tretinoin 13.5016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.5719387464 18704418 18460780 18206229 19010910 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5719850784 17596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9218055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8017506722 16331271 19075265 19225113 17649720 17368321 17712046 17107899 9834237 15748426 17361223 17217047 16891316 19642359 16788101 16140955 12679006 16766008 19035177 17339181 17294898 19029980 16823087 17301526 16935935
MESH:D015458 Leukemia, T-Cell Curcumin 4.2616106398
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.188812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.1816417039
MESH:D017880 Limb Deformities, Congenital Ethanol 11.5917676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 11.599224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 11.5916054864
MESH:D008080 Liposarcoma Paclitaxel 4.3317353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 21.8717157831 16221502 17174718 11408273 11903743 16239168 17334410 16943688 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 21.8718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 21.8718665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Ethanol 21.8715289165
MESH:D008103 Liver Cirrhosis Phenobarbital 21.8721047994
MESH:D008103 Liver Cirrhosis Vitamin A 21.8716256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5718295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 21.3515925388 18187930 18054572 17714472 18210741 16027843 15338365 15123356 17698563 15818738 17976157 12958196 18006644 18279442 15673190 10355542 18472332 17944888 15730626 17721639 18263696 17761835 12445418 15052691 18472094 18420326 16136751 12741479 17922224 18395914 16638106 15996030 17481882 13678700 12389079 15057751 17823541 18705752 14716496 18376398 15370692 18339082 17565644 16192424 12632514 18205269 16116963 15362042 16011737 12609069 15650968 18395095 14620537 16097048 15931870 17900296 16248980 15876570 18412020 17631135 17805973 17708605 18277467 14716833 15959796 11481614 16015684 17640975 18317297 12445421 12649538 17525996 14748882 18481824 17557913 18166357 17869086 12667390 15893842 12586293 12546737 12632512 12898905 18418968 14512876 16033810 12666154 17766677 14724832 18429990 18156304 20821823 18251166
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 21.3518006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 21.3514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 21.3518166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 21.3517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 21.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 21.3516248980
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 21.3517347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 21.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 21.3516248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 21.3516248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 21.3516169303
MESH:D008107 Liver Diseases Acetaminophen 13.6719460945 16611625 12969438 12587719 19784758 11587558 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 13.6716246199 16964402 15720792 15830285 17285989
MESH:D008107 Liver Diseases Curcumin 13.6716956363
MESH:D008107 Liver Diseases Diethylnitrosamine 13.6717034775
MESH:D008107 Liver Diseases Phenobarbital 13.6719363144
MESH:D008107 Liver Diseases Vitamin A 13.6716175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 9.8317347304 17207112
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 9.8316762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.352125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.3521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.3519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.3512771043 18977376 9163691 20583210 20452335 15885732 19638242 19427195 10737359 19254457 20137499 20118626 19690152 15175105 12112319 18978307 19426721 20101389 18754104 21071580 21278145 19255062 20405173 19996281 19812893 20501860 19256749 19833225 18644402 16942905 19499222 21167192 20492335 18648771 19551842 19642983 19073162 21047994 19850985 20434301 19294768 2862719 19090486 2422723
MESH:D008113 Liver Neoplasms Diethylstilbestrol 29.3516712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 29.3517045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 29.3514757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 29.3519812893 19482888 15975961 8742319 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 29.3520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.3516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.908603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.9015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.9016267830 9362446 18079962 18164116 18544905 19004024 18775883 19126423 17942915 18253720 19009564 16842330 18308698 17174075 21159647 19519916 18282651 2563599 3124819 18093689 17854601 19539802
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.9017172636 1399818 6150874 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.9012151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 18.9017113696
MESH:D008171 Lung Diseases nitrofen 10.5017245593 16863852 9614859 9859898
MESH:D008171 Lung Diseases Vitamin A 10.5016863852
MESH:D008171 Lung Diseases Vitamin E 10.5016863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 11.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.4520064080 17053015 20464547 6695378 20869020 18520028 18569708 20135361 18816296
MESH:D008175 Lung Neoplasms Cisplatin 11.4511798837 6189445 17225452
MESH:D008175 Lung Neoplasms Curcumin 11.4519359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.4521163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 11.4515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.4519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 11.4511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6215166399
MESH:D008223 Lymphoma Curcumin 10.4218462866
MESH:D008223 Lymphoma decitabine 10.4219470736
MESH:D008223 Lymphoma Diethylstilbestrol 10.4215700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.6614749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1816173963
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9816002989
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 15.1012807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.1017203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 15.1012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.1011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 15.1016827153
MESH:D020149 Manganese Poisoning Estradiol 3.9419453300
MESH:D008415 Mastocytosis Retinoids 6.0616953078
MESH:D008527 Medulloblastoma Tretinoin 2.5517453147
MESH:D008545 Melanoma Cisplatin 8.5111135225 18176117 12393984 15577323 12374674 17761969 12883367 16809738 18332650 16248763 17023156 16432458 18505091
MESH:D008545 Melanoma Curcumin 8.5118462866 17885582
MESH:D008545 Melanoma decitabine 8.5116505122 17785578
MESH:D008545 Melanoma Paclitaxel 8.5112025231 12040289 16342250
MESH:D008545 Melanoma Tretinoin 8.5116752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.2515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0519513568
MESH:D008569 Memory Disorders Curcumin 8.0917263510
MESH:D008569 Memory Disorders Ethanol 8.0918411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9116940565
MESH:D008654 Mesothelioma Cisplatin 3.0117638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.9417261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.1716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.1716757204 18986760
MESH:D009101 Multiple Myeloma Curcumin 14.1919372569
MESH:D009101 Multiple Myeloma decitabine 14.1918172295
MESH:D009101 Multiple Myeloma Paclitaxel 14.1914749477
MESH:D009101 Multiple Myeloma Vitamin A 14.1916374440
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.3917962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9916239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3818186108
MESH:D009190 Myelodysplastic Syndromes decitabine 6.4119010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4117596541
MESH:D009203 Myocardial Infarction Genistein 4.8617141266
MESH:D009203 Myocardial Infarction pirinixic acid 4.8619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.8016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.8017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.8016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9517484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3318551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.8718495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.193581430 9029167
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.1915867366
MESH:D009369 Neoplasms Benzo(a)pyrene 19.6511141357
MESH:D009369 Neoplasms Cisplatin 19.6516773208
MESH:D009369 Neoplasms decitabine 19.6519116145 17925555 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 19.6515313581
MESH:D009369 Neoplasms Fluorouracil 19.6518239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 19.6517405874
MESH:D009369 Neoplasms Tretinoin 19.6516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2117289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.9615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8418481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.4411399458
MESH:D009421 Nervous System Malformations Estradiol 25.4416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.4416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.4414600291
MESH:D009421 Nervous System Malformations Tretinoin 25.449125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0918462866
MESH:D009436 Neural Tube Defects sodium arsenate 10.3119446573 10525206 11749123 18186108
MESH:D009436 Neural Tube Defects Tretinoin 10.319142499
MESH:D009436 Neural Tube Defects Vitamin A 10.3117400914
MESH:D009447 Neuroblastoma Cisplatin 3.168761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.7518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.7520387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.178761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5820387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0716436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.449802331
MESH:D009765 Obesity Curcumin 6.4819297423
MESH:D009765 Obesity Dietary Fats 6.4819632207 16723640 17217161 18457598 21332399 18674790 20518802 11836018 20132043
MESH:D009765 Obesity pirinixic acid 6.4820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9712819281 16049721
MESH:D010014 Osteolysis Paclitaxel 4.4515867366
MESH:D010018 Osteomalacia Phenobarbital 3.8417016548
MESH:D010024 Osteoporosis Calcium 10.0317882678
MESH:D010024 Osteoporosis Curcumin 10.0318719352
MESH:D010024 Osteoporosis Genistein 10.0319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6016169203
MESH:D010051 Ovarian Neoplasms Cisplatin 23.676897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Curcumin 23.6718462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 23.6719259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 23.6719401270
MESH:D010051 Ovarian Neoplasms Genistein 23.6719005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 23.6711161223
MESH:D010051 Ovarian Neoplasms Progesterone 23.6716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 23.6716936753
MESH:D010146 Pain Acetaminophen 5.1816870215
MESH:D010146 Pain Tretinoin 5.1816870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 25.5119003803
MESH:D010190 Pancreatic Neoplasms Curcumin 25.5117440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 25.5119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 25.5116540662
MESH:D010190 Pancreatic Neoplasms Ethanol 25.5112384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 25.5116929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 25.5116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 25.5115976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.7217698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8115464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8515687053
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1516977796 15687265
MESH:D010997 Pleural Neoplasms Cisplatin 4.8017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.6912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.692563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.9517184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 18.9517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.9511896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 18.9519015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.2117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4118220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4120887781
MESH:D011471 Prostatic Neoplasms AGN 194204 3.8616000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.8617292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.8617075824
MESH:D011471 Prostatic Neoplasms Curcumin 3.8612497104 10851300 11398177 18226269 18156803 18769126 15129424
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.8615846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.8615256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.8617136230 16356831 17172428 16729912
MESH:D011471 Prostatic Neoplasms Retinoids 3.8616166285 16724957
MESH:D011471 Prostatic Neoplasms Vitamin E 3.8615084515
MESH:D011472 Prostatitis vinclozolin 4.4118629315
MESH:D011507 Proteinuria Tretinoin 3.1216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9612752131
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011625 Pterygium Tretinoin 4.2616723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.0719168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5618286688 18722050 15538739 16160472
MESH:D051437 Renal Insufficiency Cisplatin 3.9015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5410666014 18379247
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.2716877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma decitabine 9.3319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.3316116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012509 Sarcoma Curcumin 3.6618462866
MESH:D012512 Sarcoma, Ewing's Cisplatin 3.9314601052
MESH:D012640 Seizures 2,4-dinitrotoluene 7.7618551238
MESH:D012640 Seizures Ethanol 7.769754883
MESH:D012640 Seizures Phenobarbital 7.764039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.296407741
MESH:D018805 Sepsis Curcumin 3.6418389075
MESH:D012871 Skin Diseases Vitamin A 4.7118709164
MESH:D012871 Skin Diseases Vitamin E 4.7118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.3719755658 10029692
MESH:D012878 Skin Neoplasms Retinoids 11.3717538947
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.3716192470
MESH:D012878 Skin Neoplasms Tretinoin 11.3716467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8015464296
MESH:D013088 Spermatocele Diethylstilbestrol 9.9216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9216709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7515862959 16503802
MESH:D013274 Stomach Neoplasms marker/mechanism 16134180 16367923
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 11.332093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 11.3317522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 11.3319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 11.3318456281
MESH:D013274 Stomach Neoplasms Ethanol 11.3318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 11.3316424979 19015929 15786421 17498489 18396642 18567086 17522103 16951190 17172411 19084572
MESH:D013274 Stomach Neoplasms Paclitaxel 11.3318396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 11.3317261132
MESH:D013276 Stomach Ulcer Curcumin 6.0119188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 6.0117189318 17918041 9562338 11906479 9211565 16755016
MESH:D020521 Stroke Vitamin E 3.1016517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.809754883
MESH:D024801 Tauopathies Paclitaxel 4.2816930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.1417225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013964 Thyroid Neoplasms decitabine 18.2017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 18.207505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 18.201399818
MESH:D013964 Thyroid Neoplasms Retinoids 18.2016940797
MESH:D013964 Thyroid Neoplasms Tretinoin 18.2016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.1519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.3016280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.3016051514
MESH:D014376 Tuberculosis Tretinoin 2.8816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.8216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.8217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 16.8215464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Curcumin 16.8218593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 16.8217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.8216712894 16452187 17306315
MESH:D014565 Urogenital Neoplasms Curcumin 4.7318462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7910091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 18.8816803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.8816175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.8816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.8816129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.8115809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8114692618
MESH:D014604 Uveal Neoplasms decitabine 11.0417785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.0416752155
MESH:D014605 Uveitis Cyclosporine 3.451336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.3715577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.3716513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D014689 Venous Insufficiency coumarin 5.2412708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0715869587 14671159
MESH:D014802 Vitamin A Deficiency Vitamin A 4.7916960172 16175781 16146918
MESH:D014820 Vitiligo Tretinoin 3.5616761959
MESH:D014839 Vomiting Cisplatin 4.1811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D015430 Weight Gain Dietary Fats 3.2916723640
MESH:D009396 Wilms Tumor Tretinoin 3.5216287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9017120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00760 Nicotinate and nicotinamide metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34286
  • No data
    Releated disease ID Related disease Name
    PA152241952Congenital diaphragmatic hernia
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00162 - Z-Mass Pm Vitamin and Mineral Supplement Essential Vitamin;Anti-acne Agents;Vitamins (Vitamin A);Vitamins
    DB00459 agonist Acitretin Keratolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018