AutismKB 2.0

Annotation Detail for RDX


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RDX ( DFNB24 )
Gene Full Name: radixin
Band: 11q23
Quick LinksEntrez ID:5962; OMIM: 179410; Uniprot ID:RADI_HUMAN; ENSEMBL ID: ENSG00000137710; HGNC ID: 9944
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200007RhoA signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1904Diabetes mellitus
2052Infection
2207Deafness
No data
No data
Desease Name
Deafness, autosomal recessive, 24
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RDX mRNAaffects expression 17562736
D003913 Dextroamphetamine Dextroamphetamine affects the expression of RDX mRNAaffects expression 12205029
D003913 Dextroamphetamine SOD1 affects the reaction [Dextroamphetamine affects the expression of RDX mRNA]affects expression|affects reaction 12205029
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RDX mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of RDX mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of RDX mRNAincreases expression 19194470
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of RDX mRNAdecreases expression 16498641
D004958 Estradiol Estradiol results in increased expression of RDX mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the localization of RDX proteinaffects localization 17681005
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RDX mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RDX protein modified formdecreases expression 17681005
D005472 Fluorouracil Fluorouracil affects the expression of RDX mRNAaffects expression 16584549
C029424 hydrazine hydrazine results in increased expression of RDX mRNAincreases expression 15282401
D007529 Isoflavones Isoflavones results in increased expression of RDX mRNAincreases expression 17374662
C015329 lycopene lycopene results in decreased expression of RDX mRNAdecreases expression 16886892
C006253 pirinixic acid pirinixic acid results in decreased expression of RDX mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RDX mRNAdecreases expression 18796159
D019772 Topotecan RDX protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014501 Uranium Uranium affects the expression of RDX mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of RDX mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin results in decreased expression of RDX mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Estradiol 7.0011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0014692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0017638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.7616487989
MESH:D000505 Alopecia Isoflavones 4.6817569567
MESH:D000740 Anemia Fluorouracil 8.5517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms decitabine 2.3519208741 18320071
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 2.3515061365
MESH:D001943 Breast Neoplasms Estradiol 2.3517018787 19861407 12948864 17289903 17261762 18497071 16675129 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.3516110121 16595493 18357371 16557594 19217205 18608205 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.513084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.5116332177 17045692 16799960 17971768 18930000 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0018695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8019215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8018986760 17066447 16280240 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Isoflavones 4.1217689850
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.9620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.9618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis marker/mechanism 17681005
MESH:D002779 Cholestasis Cyclosporine 13.1519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1515861022 17333356 16105132 11677210 16919318 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 13.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.088697196 15668235 16354765 15340226 12621046
MESH:D003110 Colonic Neoplasms decitabine 3.8417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8417725105 17169374 15001691 17018589 16510598 17172411 17016597 17287894 16340194 18772588
MESH:D015179 Colorectal Neoplasms decitabine 3.5918981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5915148649 16303861 15289873 18509181 17016601 16391804 17401013 17454858 17594712 18802399 17094418 18383874 18448328 16282729 17255274 17695437 18949393 16524972 14970324 20501625 18288408 16331619
MESH:D015179 Colorectal Neoplasms Isoflavones 3.5917116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
OMIM:611022 DEAFNESS, AUTOSOMAL RECESSIVE, 24 marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5116485898 19420014 17562736 16081117 10774834 11834606 10663392 2444490 12153990 15968718 16393943 19085960 12540782 14986274 19416960 15619225 11743745 12594235 14550746 12705907 18713872 16177239 12392966 11421492 16781746 19923254 11739529 17906064 11529661 12958197 14725611 18071297 19370779 17522070 19739265 10915739 11461765 19164858 11287661 16109766 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.2416487989
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0919294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.9518566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4720426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4716481741 16337965 16785472 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Cyclosporine 12.7719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.7715345470
MESH:D005234 Fatty Liver pirinixic acid 12.7720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 8.3512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.8019215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8015102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 5.0016487989
MESH:D006529 Hepatomegaly pirinixic acid 8.1319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1312621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 10.3317088409
MESH:D019584 Hot Flashes Isoflavones 10.3314716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male decitabine 15.8817581917
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 15.8817192596 12948891
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.8817937319
MESH:D007248 Infertility, Male vinclozolin 15.8816467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.838314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 9.8315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2012371664
MESH:D007680 Kidney Neoplasms Estradiol 12.2015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.2016985049
MESH:D007938 Leukemia decitabine 3.0518980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.9617236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3719010910 18704418 18460780 19387464 17679729 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.6612745335
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6216610002 12969438 11587558 19784758 19460945 16611625 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 7.2716603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 7.2716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3315246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008223 Lymphoma decitabine 3.3919470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5311408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008545 Melanoma decitabine 2.2416505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009041 Motion Sickness Dextroamphetamine 5.491613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6016757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.3118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3619010910 19157545 18608210 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009369 Neoplasms decitabine 11.7619470736 17925555 19116145
MESH:D009369 Neoplasms Fluorouracil 11.7618239605 16928823 18600527
MESH:D009369 Neoplasms lycopene 11.7617051425
MESH:D009369 Neoplasms pirinixic acid 11.7617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.3311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D009447 Neuroblastoma Topotecan 3.8315176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D010024 Osteoporosis Isoflavones 4.0716562857
MESH:D010051 Ovarian Neoplasms decitabine 4.8719331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 4.8719401270
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.4019294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4015113037 16929163 16500647 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3711399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.3718042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.6917616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.2016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2019082440 18626508
MESH:D011471 Prostatic Neoplasms Isoflavones 2.2017374662 17219775 17571952 16365062
MESH:D011471 Prostatic Neoplasms lycopene 2.2015084515 17337101
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9715538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3619155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms decitabine 2.6119037991
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6118396642 19084572 17522103 16424979 18567086 15786421 16951190 17172411 19015929 17498489
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.2917967635
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9516280240
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7017616700 19087683
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.7116487989
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms decitabine 4.8817785578
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34311
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03401 - D-Myo-Inositol-1,4,5-Triphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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