AutismKB 2.0

Annotation Detail for REL


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Basic Information Top
Gene Symbol:REL ( C-Rel )
Gene Full Name: v-rel reticuloendotheliosis viral oncogene homolog (avian)
Band: 2p16.1
Quick LinksEntrez ID:5966; OMIM: 164910; Uniprot ID:REL_HUMAN; ENSEMBL ID: ENSG00000162924; HGNC ID: 9954
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200017Atypical NF-kappaB pathway
200102Regulation of Androgen receptor activity
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00007Hodgkin lymphoma
Desease IDDesease Name
1788Infiltrating cancer
1944Breast cancer
1976Squamous cell cancer
2161Hodgkin's disease
2220Dermatitis
Desease Name
rheumatoid arthritis
Celiac Disease
ulcerative colitis
IMMUNE
Desease Name
Rheumatoid arthritis
Celiac disease
Ulcerative colitis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C417207 2,2',4,6,6'-pentachlorobiphenyl 2,2',4,6,6'-pentachlorobiphenyl results in increased activity of REL proteinincreases activity 16611624
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of REL mRNAincreases expression 16014739
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of REL protein]decreases reaction|increases activity 15772366
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of REL mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of REL mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of REL proteindecreases expression 18349030
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of REL mRNAdecreases expression 12419474
D002258 Carbonyl Cyanide m-Chlorophenyl Hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of REL proteinincreases expression 15978749
C503589 cis-9, trans-11-conjugated linoleic acid cis-9, trans-11-conjugated linoleic acid affects the activity of REL proteinaffects activity 17327424
C007262 deoxynivalenol 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of REL protein]decreases reaction|increases activity 15772366
C007262 deoxynivalenol deoxynivalenol affects the localization of REL proteinaffects localization 12604842
C007262 deoxynivalenol deoxynivalenol results in decreased activity of [REL protein binds to NFKB1 protein]affects binding|decreases activity 8887449
C007262 deoxynivalenol deoxynivalenol results in increased activity of REL proteinincreases activity 15772366
D004041 Dietary Fats Dietary Fats results in decreased expression of REL mRNAdecreases expression 18042831
D015127 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]]affects binding|decreases reaction|increases reaction 14678569
D004317 Doxorubicin Doxorubicin affects the localization of REL proteinaffects localization 15870702
D004317 Doxorubicin Doxorubicin results in decreased expression of REL mRNAdecreases expression 16404146
D004317 Doxorubicin REL protein affects the susceptibility to Doxorubicinaffects response to substance 17890907
D005033 Ethylmaleimide Ethylmaleimide results in decreased phosphorylation of REL proteindecreases phosphorylation 11085954
D005620 Freund's Adjuvant [Urethane co-treated with Freund's Adjuvant] results in increased expression of REL mRNAaffects cotreatment|increases expression 12400877
C007789 fucoidan fucoidan results in decreased activity of REL proteindecreases activity 16201850
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased localization of REL proteindecreases localization 16249388
D006861 Hydrogen Peroxide Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]decreases localization|decreases reaction 16249388
C050016 lipoarabinomannan lipoarabinomannan results in decreased localization of and results in decreased activity of REL proteindecreases activity|decreases localization 16263713
D008070 Lipopolysaccharides 9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]]affects binding|decreases reaction|increases reaction 14678569
D008070 Lipopolysaccharides Lipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]affects binding|increases reaction 14678569
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of and results in increased localization of REL proteinincreases activity|increases localization 19159680
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of REL mRNAincreases expression 20423518
12057914
D008070 Lipopolysaccharides Lithium promotes the reaction [Lipopolysaccharides results in increased localization of REL protein]increases localization|increases reaction 19159680
D008070 Lipopolysaccharides phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]decreases reaction|increases expression 20423518
D008094 Lithium Lithium promotes the reaction [Lipopolysaccharides results in increased localization of REL protein]increases localization|increases reaction 19159680
C029938 nickel sulfate nickel sulfate results in decreased expression of REL mRNAdecreases expression 16780908
C029938 nickel sulfate nickel sulfate results in increased expression of REL mRNAincreases expression 16780908
D009761 Nystatin Nystatin results in increased activity of REL proteinincreases activity 16374455
C041786 palm oil palm oil results in decreased expression of REL mRNAdecreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]decreases reaction|increases expression 20423518
C008922 piperine piperine results in decreased localization of REL proteindecreases localization 15531295
C526689 punarnavine punarnavine results in decreased localization of REL proteindecreases localization 20192578
D019438 Ritonavir Ritonavir results in decreased activity of REL proteindecreases activity 16174765
C018145 scoparone scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein]affects localization|decreases reaction 16376386
C017947 sodium arsenite sodium arsenite results in increased expression of REL mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of REL mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [TNF protein results in increased localization of REL protein]decreases reaction|increases localization 12181450
D013755 Tetradecanoylphorbol Acetate scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein]affects localization|decreases reaction 16376386
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of REL proteinaffects localization 16376386
D014212 Tretinoin Tretinoin results in increased expression of REL mRNAincreases expression 16140955
D014268 Trifluoperazine Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]decreases localization|decreases reaction 16249388
D014415 Tunicamycin Tunicamycin results in increased expression of REL mRNAincreases expression 17127020
D014520 Urethane [Urethane co-treated with Freund's Adjuvant] results in increased expression of REL mRNAaffects cotreatment|increases expression 12400877
D014520 Urethane Urethane results in increased expression of REL mRNAincreases expression 12400877
D014635 Valproic Acid Valproic Acid results in increased expression of REL mRNAincreases expression 19101580
D015215 Zidovudine REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]affects cotreatment|decreases response to substance 17138822
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0514514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.459612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.3211850527 18653653
MESH:D055371 Acute Lung Injury nickel sulfate 8.3219131640 16100012 11954676 12718980
MESH:D000230 Adenocarcinoma 9,10-Dimethyl-1,2-benzanthracene 9.4412844480 10697514
MESH:D000230 Adenocarcinoma arsenic trioxide 9.4411798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.4417418594
MESH:D000230 Adenocarcinoma Urethane 9.4418316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.3215814487
MESH:D000236 Adenoma 9,10-Dimethyl-1,2-benzanthracene 7.0011376689
MESH:D000236 Adenoma Urethane 7.0011497255 16926031 10822126 10530776 6695378 17195641 17093202
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5117306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.1821441931
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000544 Alzheimer Disease Lithium 3.3819621015
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.2717497229
MESH:D001161 Arteriosclerosis Dietary Fats 3.5215238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.8416412693
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 19503088 20453842
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518775368 18316065 17157402 18940202 16609825 20603192 18177632 18558336 17688650 15238991 19232924 18396377 17507914 18985861 19460635
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001714 Bipolar Disorder Lithium 6.9520338123 19153942 20046352 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 6.9520046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.3716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.3716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3114601052
MESH:D001862 Bone Resorption Freund's Adjuvant 4.7916769263
MESH:D001932 Brain Neoplasms Doxorubicin 3.4817150277
MESH:D001943 Breast Neoplasms 9,10-Dimethyl-1,2-benzanthracene 2.2315565634 20435547 17127718 18840765 16153821
MESH:D001943 Breast Neoplasms Dietary Fats 2.2320435547
MESH:D001943 Breast Neoplasms Doxorubicin 2.2317369602 16096432 15993339 15136595 16115903 18695136 15567936 18628466 16826403 18382427 17426702 15939500 15692762 16935488 18234424 16264153 11325840 15634643 19526202 16595493 15994142 17983394 15668708 16322301
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9811589617
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4216051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.113084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.1114691202 15553829 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.1116023760 16234567 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.1116507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.111917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4919014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.981485588 16201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7912490120
MESH:D002294 Carcinoma, Squamous Cell 9,10-Dimethyl-1,2-benzanthracene 13.0611376689
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.066189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.0618572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.0618922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.0616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.2816109756 17928571 17924179 17007740 17351982 16455267 18627295 16952015 17382496 16278810 17308081 17519947 16651473 16364871 15505089 15792986 15476868 16612575 16269455 15811867 17974986 16242529 16731534 17131338 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8117334414 16243910
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2516936243
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.7320056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9415668235 16354765 12621046 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 8.949407595
MESH:D002972 Cleft Palate Urethane 8.9412810352
MESH:D003092 Colitis Tretinoin 3.3317035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5120423518
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5020501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5018259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.9910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.9917551590 8800419 10589399 9224671 16925845 14991402 9664655 9211117 9142499 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.998888407 17688650 16575769
MESH:D007644 Darier Disease Lithium 5.5320338123
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7415213294
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.3211298694 16780908 16823706
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.3719244398
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.7011739529 12594235 11287661 16227642 19739265 19420014 11743745 19923254 16177239 14986274 12705907 11834606 16781746 16081117 17906064 16393943 19416960 16485898 18071297 2444490 18713872 11529661 11461765 16109766 11421492 19164858 17522070 12392966 10915739 10774834 15968718 17562736 19085960 19370779 14725611 12958197 12153990 15619225 10663392 14550746 12540782
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 10.7017416283
MESH:D056486 Drug-Induced Liver Injury Ritonavir 10.7014986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.7020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.701733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Doxorubicin 12.1618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.1611462148
MESH:D004362 Drug Toxicity Zidovudine 12.1615040536
MESH:D050171 Dyslipidemias Dietary Fats 3.1818367378
MESH:D004421 Dystonia Valproic Acid 3.701851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 5.8516716910 7812673 9599246 11698051 8273558 8113982 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.7517359293
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.699294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7718037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0215328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.783659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.276426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.683659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.909664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 16.0515073043
MESH:D005234 Fatty Liver Dietary Fats 16.0517967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Valproic Acid 16.0514986274 19224547
MESH:D005234 Fatty Liver Zidovudine 16.0518299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.7718558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.6911852909 9205823
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2119069698
MESH:D005355 Fibrosis Dietary Fats 12.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6220067830
MESH:D005355 Fibrosis Tretinoin 12.6217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9016904648
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3016452187
MESH:D005909 Glioblastoma Doxorubicin 6.4117150277
MESH:D005909 Glioblastoma Tretinoin 6.4117312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.7115173396 16524712
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.9915692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006330 Heart Defects, Congenital Lithium 10.1019638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.109664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 7.2216879835 12587719 16244372 16244371 18006777 18674790 16495754 14766674 17875725 17888722 16144979 16330681 16707910
MESH:D006331 Heart Diseases Urethane 7.2216046796
MESH:D006333 Heart Failure Doxorubicin 3.1117481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5615692506
MESH:D006402 Hematologic Diseases Zidovudine 4.3612579204
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5316120746 12621046 15340226
MESH:D015658 HIV Infections Ritonavir 6.6817378895 11363243 15388451 11141242
MESH:D015658 HIV Infections Zidovudine 6.6811141242 20032539 11363243 11698656 17358032
MESH:D006689 Hodgkin Disease marker/mechanism 21037568
MESH:D006689 Hodgkin Disease Doxorubicin 6.4317606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 6.4312676792
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.668697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 11.4716870215
MESH:D006930 Hyperalgesia Freund's Adjuvant 11.4716769263
MESH:D006930 Hyperalgesia Tretinoin 11.4716870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 2.7412646999 15346721
MESH:D007249 Inflammation Dietary Fats 13.7220412841
MESH:D007249 Inflammation Freund's Adjuvant 13.7216793879
MESH:D007249 Inflammation Lipopolysaccharides 13.7217237260 9205823 12878042 17963957 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.7212878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 13.7211698051 7812673 15177302 8273558 7562506
MESH:D007333 Insulin Resistance Dietary Fats 2.8618457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8015992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 8.8012587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 8.8016775033 15369732 15699352
MESH:D007674 Kidney Diseases sodium arsenite 8.8020008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.9916707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.9916518626
MESH:D007680 Kidney Neoplasms Zidovudine 3.4812579204
MESH:D007938 Leukemia arsenic trioxide 5.6915070760
MESH:D007938 Leukemia Tretinoin 5.6917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7716085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 14.5317077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 14.5316174765
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 14.5320370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.3419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.3416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.6419850784 17050201 16968895 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.6419850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.6417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.8012712474 16112521 17107899 16330433 19075265 16331271 12679006 15748426 16823087 16966277 17869043 12018890 15622746 11161223 17649720 17217047 19225113 11468182 19642359 15336539 17712046 9834237 15213294 19035177 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.8017368321 19029980 16766008 16891316 16140955 19642359 15748426 19225113 16331271 19035177 17217047 17107899 17506722 17294898 12679006 16823087 9834237 16935935 17339181 16788101 19075265 17301526 17712046 17649720 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9916882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.3215821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.6718296743
MESH:D008106 Liver Cirrhosis, Experimental cis-9, trans-11-conjugated linoleic acid 6.1917869086
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.1916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.1912878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.5416610002 16611625 19014921 12969438 19784758 11587558 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9117185352 16871587
MESH:D008113 Liver Neoplasms 9,10-Dimethyl-1,2-benzanthracene 12.639643874
MESH:D008113 Liver Neoplasms arsenic trioxide 12.6314682389
MESH:D008113 Liver Neoplasms sodium arsenite 12.6316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.6316984957
MESH:D008113 Liver Neoplasms Urethane 12.6317559639 17093202 16391232
MESH:D008114 Liver Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 12.231399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.2320377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.2317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0615213294
MESH:D008171 Lung Diseases sodium arsenite 2.9219095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8717228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.6421114838
MESH:D008175 Lung Neoplasms 9,10-Dimethyl-1,2-benzanthracene 12.0211376689
MESH:D008175 Lung Neoplasms arsenic trioxide 12.0219825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 12.026189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 12.0216712894 17306315 15276417 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.0219555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 12.0211807781
MESH:D008175 Lung Neoplasms Urethane 12.0212765245 7750092 16926031 16007126 12466968 15902970 14587096 16391232 11807781 11246140 11552296 17093202 17255336 17195641 15136453 12117781 10822126 11062179 11992545 16337739 11074608 10779650 16289808 16788158 12957351 11497255 11544531 10530776 11323394 15166089 10997738 16204055 11307925 6695378 11893704
MESH:D008175 Lung Neoplasms Zidovudine 12.0218800350
MESH:D008223 Lymphoma 9,10-Dimethyl-1,2-benzanthracene 7.3211376689
MESH:D008223 Lymphoma Doxorubicin 7.3216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1915621674
MESH:D008325 Mammary Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 8.9016082771 18840765 1500032 16153821 8985016 12844480 11807958 10697514
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.9015458769
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.908985016
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Doxorubicin 4.7016827129
MESH:D008545 Melanoma sodium arsenite 4.7016487513 19082730
MESH:D008545 Melanoma Tretinoin 4.7016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008654 Mesothelioma Doxorubicin 2.9017638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4517358032
MESH:D008881 Migraine Disorders Valproic Acid 2.9218765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1615792986
MESH:D052016 Mucositis Doxorubicin 4.4117415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8414977855 15949261 19549372 19417148 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009164 Mycobacterium Infections Ritonavir 5.3921442799
MESH:D009181 Mycoses Nystatin 6.3816374455
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.0216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.0217596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.0217596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.8119429709 15857846
MESH:D009203 Myocardial Infarction Lithium 5.8116288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6016624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0818259882
MESH:D009362 Neoplasm Metastasis punarnavine 6.0819171408
MESH:D009369 Neoplasms 9,10-Dimethyl-1,2-benzanthracene 10.3911544531
MESH:D009369 Neoplasms sodium arsenite 10.3911559025
MESH:D009369 Neoplasms Tretinoin 10.3916946489 16594593
MESH:D009369 Neoplasms Urethane 10.3915625555
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.2420056578
MESH:D009374 Neoplasms, Experimental Urethane 8.2415582191
MESH:D009401 Nephrosis Doxorubicin 4.4016899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6816889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3114600291
MESH:D009421 Nervous System Malformations Tretinoin 8.319125849
MESH:D009436 Neural Tube Defects arsenic trioxide 15.2710525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.2712854658
MESH:D009436 Neural Tube Defects Tretinoin 15.279142499
MESH:D009436 Neural Tube Defects Valproic Acid 15.278888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 3.0615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D009503 Neutropenia Ritonavir 5.0217378895
MESH:D009765 Obesity Dietary Fats 2.1916723640 21332399 20132043 19632207 18674790 18457598 17217161 11836018 20518802
MESH:D012516 Osteosarcoma Doxorubicin 3.8115930896
MESH:D010051 Ovarian Neoplasms 9,10-Dimethyl-1,2-benzanthracene 13.6216891317
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.6216624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.6215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 13.6216936753
MESH:D010051 Ovarian Neoplasms Urethane 13.6216391232
MESH:D010146 Pain Acetaminophen 5.5816870215
MESH:D010146 Pain Tretinoin 5.5816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.8515580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.8515976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.8515976015
MESH:D010212 Papilloma 9,10-Dimethyl-1,2-benzanthracene 13.7216517061 15173996 17234724
MESH:D010212 Papilloma Hydrogen Peroxide 13.7212065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 13.7218922899 8330346 18404319 12065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1111550810
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7717983394
MESH:D010911 Pituitary Neoplasms Urethane 5.0416391232
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7717638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1712224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2011399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.2020603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7619131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7616868541 16888761 16729912 15749863 15897917 18437689
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7616039940
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.1512752131 11422049
MESH:D011565 Psoriasis marker/mechanism 20953190
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D051437 Renal Insufficiency Doxorubicin 3.8517922066
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.7016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.7019155313
MESH:D012509 Sarcoma Doxorubicin 3.6615625365 18313854 17710206 15675481 17203757 16767912
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.0816646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.0816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4117846226
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures Lithium 5.6219660546
MESH:D012640 Seizures Valproic Acid 5.6216876388 3137016 17978042 14763951 11738929 11044598 15475178 1511512
MESH:D012878 Skin Neoplasms 9,10-Dimethyl-1,2-benzanthracene 33.3915173996 8985016 16517061 11376689
MESH:D012878 Skin Neoplasms Doxorubicin 33.3915692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 33.3912065085
MESH:D012878 Skin Neoplasms sodium arsenite 33.3919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 33.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 33.3916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 33.3918404319 8985016 8330346 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 33.3916467112
MESH:D012878 Skin Neoplasms Urethane 33.3911807781
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1915625365 16767912 17203757
MESH:D016135 Spinal Dysraphism sodium arsenite 8.5712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.5719490988
MESH:D013226 Status Epilepticus Lithium 11.3719430551 19951488 19570321
MESH:D013226 Status Epilepticus Valproic Acid 11.3712833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2317007042
MESH:D013274 Stomach Neoplasms Tretinoin 3.2317261132
MESH:D013274 Stomach Neoplasms Zidovudine 3.2317696246
MESH:D013276 Stomach Ulcer fucoidan 4.7715138204 18209962
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.5615864552
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8415821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 14.8416940797
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.8419014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.8417909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 14.8416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.4616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5815213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.4712845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.4717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.4717306315 11723127 16712894 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.3216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014625 Vaginal Neoplasms Zidovudine 4.3912579204
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D019043 Vascular Neoplasms Urethane 5.5210620525
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8517334414 17638931 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34321
    • Releated gene ID Related gene Name
    PA248NFKB1
    PA30196KRAS
    PA36348TBK1
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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