AutismKB 2.0

Annotation Detail for RENBP


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Basic Information Top
Gene Symbol:RENBP ( RBP,RNBP )
Gene Full Name: renin binding protein
Band: Xq28
Quick LinksEntrez ID:5973; OMIM: 312420; Uniprot ID:RENBP_HUMAN; ENSEMBL ID: ENSG00000102032; HGNC ID: 9959
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
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Related Diseases/Disorders Top
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Desease Name
renin binding protein
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RENBP mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RENBP mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RENBP mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of RENBP mRNAincreases expression 18929588
C095105 bexarotene bexarotene results in increased expression of RENBP mRNAincreases expression 16648578
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of RENBP mRNAincreases expression 14729362
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RENBP mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms bexarotene 2.9616344269 16818667
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.927296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.3016247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.5219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 14531868 8970840 11906362 2524372 8156756 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9418692083 7440962 6679447 9022650 16192314 11289319 6482804 18289764 8291058 1440618 18648102 9653073 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.942444490 11461765 11529661 18071297 19923254 17906064 19420014 19164858 19739265 16227642 12594235 11834606 15619225 14986274 18713872 19085960 14725611 19370779 11743745 11287661 11739529 16177239 10663392 16081117 12153990 16109766 14550746 12705907 16781746 12958197 12540782 17562736 16393943 16485898 15968718 10774834 12392966 10915739 11421492 17522070 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver arsenite 8.8518296743
MESH:D005234 Fatty Liver pirinixic acid 8.8519236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis arsenite 4.4218296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008103 Liver Cirrhosis arsenite 3.5518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6812587719 12969438 19460945 19784758 16610002 19014921 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.693712494 6587162 1399818 598648
MESH:D008175 Lung Neoplasms arsenite 3.0116809336
MESH:D008175 Lung Neoplasms bexarotene 3.0117849452
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.5111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.5715591091 19196723 19196722
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.2319196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.8115738583
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.093712494 6582329 6587162 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.368074119
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00141 - N-Acetyl-D-glucosamine Dietary supplement;Micronutrient
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Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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