AutismKB 2.0

Annotation Detail for REST


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Basic Information Top
Gene Symbol:REST ( NRSF,XBR )
Gene Full Name: RE1-silencing transcription factor
Band: 4q12
Quick LinksEntrez ID:5978; OMIM: 600571; Uniprot ID:REST_HUMAN; ENSEMBL ID: ENSG00000084093; HGNC ID: 9966
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1917Cerebellar disease
1983Down syndrome
2001Mental retardation
Desease Name
NEUROLOGICAL
cognitive ability
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105351 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of REST mRNAincreases expression 17873293
D000082 Acetaminophen Acetaminophen affects the expression of REST mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in increased expression of REST mRNAincreases expression 16648578
D000643 Ammonium Chloride Ammonium Chloride affects the expression of REST mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of REST mRNAincreases expression 20458559
C095105 bexarotene bexarotene results in increased expression of REST mRNAincreases expression 16648578
D002220 Carbamazepine Carbamazepine inhibits the reaction [REST protein results in increased expression of TAC3 mRNA]decreases reaction|increases expression 19539370
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of REST mRNAdecreases expression 16934159
D005472 Fluorouracil Fluorouracil affects the expression of REST mRNAaffects expression 16584549
D008713 Methimazole Methimazole results in increased expression of REST mRNAincreases expression 17403546
C494474 perchlorate perchlorate results in increased expression of REST mRNAincreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in increased expression of REST mRNAincreases expression 17403546
D014284 Triiodothyronine Triiodothyronine results in decreased expression of REST mRNAdecreases expression 17399805
D013974 Thyroxine Thyroxine results in decreased expression of REST mRNAdecreases expression 17403546
D013974 Thyroxine Thyroxine results in increased expression of REST mRNAincreases expression 17403546
C012589 trichostatin A trichostatin A results in decreased activity of REST proteindecreases activity 16330548
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.598986270
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5419825857 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.5417638652
MESH:D000740 Anemia Fluorouracil 3.7416511603 15504547 17963324
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001714 Bipolar Disorder Carbamazepine 4.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5116206674
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 9.5119483382
MESH:D001943 Breast Neoplasms alitretinoin 2.1516344269
MESH:D001943 Breast Neoplasms bexarotene 2.1516344269 16818667
MESH:D001943 Breast Neoplasms Fluorouracil 2.1515136595 16110121 18357371 16557594 19217205 16595493 18608205
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 3.5917121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6015073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6016332177 17088986 16799960 17045692 18930000 17971768
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5017066447 16757204 18986760 16280240
MESH:D006332 Cardiomegaly Thyroxine 4.1218093424
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417725105 17018589 15001691 17169374 16510598 17016597 18772588 16340194 17287894 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5520501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5516391804 17255274 18802399 17594712 17695437 16303861 17401013 15148649 16282729 18949393 16331619 17094418 16524972 15289873 20501625 17016601 17454858 18448328 18509181 18288408 14970324 18383874
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.1010525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.109014606
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.4911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4216538176 16538175 15057820 20216337
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5219739265 16485898 10663392 11834606 19164858 19370779 19923254 11421492 12594235 17562736 11743745 17522070 11461765 17906064 14550746 16081117 11739529 10774834 18713872 12958197 11529661 19085960 12540782 12705907 12153990 11287661 2444490 16177239 16781746 15968718 15619225 14986274 19420014 16393943 19416960 18071297 10915739 12392966 16109766 14725611 16227642
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 6.5217465707
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.5217851650
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Carbamazepine 4.4820216337
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.7717654737
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.7019294695
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.2919915237 16415921 16538176 18855540 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.2517275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.0416628512 17116037 15008574
MESH:D004827 Epilepsy Carbamazepine 4.0019620853 821787 19439326 20417680 7988514 18234410 17178248 9014606 19700373 17465707
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.173659116 15276670
MESH:D004916 Erythromelalgia Carbamazepine 5.7719549232
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6212903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6216481741 15173087 17638652 16785472 16337965
MESH:D005076 Exanthema Carbamazepine 5.5220485159
MESH:D005234 Fatty Liver arsenic trioxide 3.3215073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005909 Glioblastoma trichostatin A 3.8518801729
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006042 Goiter perchlorate 5.3418801409
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4015102660 15162350 18337622
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7510459572
MESH:D006965 Hyperplasia Carbamazepine 5.2518773962
MESH:D006980 Hyperthyroidism Methimazole 5.6514678291
MESH:D007037 Hypothyroidism Methimazole 12.0918031379
MESH:D007037 Hypothyroidism Propylthiouracil 12.098137927 18031379
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6916144296
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3316985049
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.2016968895 16467208 17050201 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.2018206229
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2319225113 19075265 16966277 19642359 15622746 16112521 15213294 11468182 17869043 17649720 12018890 15748426 17217047 12712474 12679006 15336539 16891316 16823087 11161223 9834237 16331271 17107899 16330433 17712046 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 19784758 16610002 19460945 11587558 16611625 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7514682389
MESH:D008113 Liver Neoplasms Fluorouracil 4.7517045692 18383874 15113037 16603448
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.7520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008175 Lung Neoplasms alitretinoin 4.9816413115
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9811798837 19825857
MESH:D008175 Lung Neoplasms bexarotene 4.9817849452
MESH:D008175 Lung Neoplasms Fluorouracil 4.9815246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5716628512
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1911161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4219196723 15591091 19196722
MESH:D008545 Melanoma trichostatin A 2.7716505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008607 Mental Retardation Carbamazepine 3.739014606
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6518986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6415949261 19417148 11468182 14977855 19549372
MESH:D009101 Multiple Myeloma trichostatin A 7.6418172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616882451 16105982
MESH:D009224 Myotonia Congenita Carbamazepine 5.5220399394
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009369 Neoplasms alitretinoin 5.5116946489
MESH:D009369 Neoplasms Fluorouracil 5.5116928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8519196722
MESH:D009421 Nervous System Malformations Carbamazepine 4.9416990009
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1310525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D010018 Osteomalacia Carbamazepine 5.5217016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms trichostatin A 5.2119331143
MESH:D010146 Pain Acetaminophen 7.0816870215
MESH:D010146 Pain Carbamazepine 7.0815215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8115580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8116929163 19003803 16500647 15113037
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.8119294695
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010267 Parapsoriasis Carbamazepine 5.7416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9717145499 17679678
MESH:D017499 Porokeratosis alitretinoin 6.0716144296
MESH:D011248 Pregnancy Complications Carbamazepine 5.199014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 4.949014606
MESH:D055728 Primary Myelofibrosis trichostatin A 5.2917616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7119131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7118626508 19082440
MESH:D011471 Prostatic Neoplasms trichostatin A 2.7119789329 18798265
MESH:D019310 Pseudolymphoma Carbamazepine 5.669591791 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0418286688 18722050 16160472 15538739
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012640 Seizures Carbamazepine 3.819844417 19414003 9046859 16180713 16876388 16938433 15946322
MESH:D012893 Sleep Disorders Carbamazepine 5.1719414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2516415921 19694795 15057820 16538176 18855540 19915237 20485159
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5417007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5418567086 18396642 17172411 16424979 15786421 17498489 19084572 16951190 19015929 17522103
MESH:D013959 Thyroid Diseases Thyroxine 5.7019910387
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5219014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.5215710170
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4912845720 12973940 20435036 11780464
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9016803524
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34334
    • Releated gene ID Related gene Name
    PA27545DYRK1A
    PA26228CD59
    Releated disease ID Related disease Name
    PA443933Down Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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