AutismKB 2.0

Annotation Detail for RET


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RET ( CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51 )
Gene Full Name: ret proto-oncogene
Band: 10q11.21
Quick LinksEntrez ID:5979; OMIM: 164761; Uniprot ID:RET_HUMAN; ENSEMBL ID: ENSG00000165731; HGNC ID: 9967
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05216Thyroid cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200058Signaling events regulated by Ret tyrosine kinase
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00032Thyroid cancer
Cancers of endocrine organs
Desease IDDesease Name
1750Endocrine system disease
1757Multiple endocrine neoplasia
1781Rheumatoid arthritis
1786Neck cancer
1934Cancer
1946Thyroid gland disease
1982Myopathy
2105Primary hyperparathyroidism
Desease Name
ovarian cancer
Multiple Endocrine Neoplasia Type 2a
germline mutations
CANCER
thyroid carcinoma, sporadic medullary
medullary sponge kidney disease
RENAL
thyroid cancer
multiple endocrine neoplasia
C-cell hyperplasia
Hirschsprung's disease intestinal neuronal dysplasia
Hirschsprung's disease
Pheochromocytoma
sporadic pheochromocytoma
Desease Name
Hirschsprung's disease
Desease Name
Central hypoventilation syndrome, congenital
Renal agenesis
Hirschsprung disease
Pheochromocytoma
Multiple endocrine neoplasia IIB
Multiple endocrine neoplasia IIA
Medullary thyroid carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine results in decreased activity of RET proteindecreases activity 16940797
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RET mRNAaffects expression 16483693
D000841 Anisomycin Anisomycin results in decreased expression of RET proteindecreases expression 17555550
C006780 bisphenol A bisphenol A results in decreased expression of RET mRNAdecreases expression 12075121
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 12634122
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 20360939
D002166 Camptothecin Camptothecin results in decreased expression of RET proteindecreases expression 17555550
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RET mRNAaffects expression 12734012
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 12634122
D003513 Cycloheximide Cycloheximide results in decreased expression of RET proteindecreases expression 17555550
C017180 decamethrin decamethrin results in increased expression of RET mRNAincreases expression 19017407
D002945 Cisplatin Cisplatin results in decreased expression of RET proteindecreases expression 17555550
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 20360939
D002117 Calcitriol Calcitriol results in increased expression of RET mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RET mRNAdecreases expression 12075121
D019833 Genistein Genistein results in increased expression of RET mRNAincreases expression 12075121
C097613 imatinib imatinib results in decreased phosphorylation of RET proteindecreases phosphorylation 15709206
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 12634122
C533894 LG 100815 LG 100815 results in decreased expression of RET mRNAdecreases expression 16951191
C025340 manganese chloride manganese chloride results in decreased expression of RET proteindecreases expression 17555550
D008468 Meclizine Meclizine affects the expression of RET proteinaffects expression 12388792
D008535 Megestrol Megestrol affects the expression of RET proteinaffects expression 12388792
D008704 Methazolamide Methazolamide affects the expression of RET proteinaffects expression 12388792
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RET proteindecreases expression 17555550
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased phosphorylation of RET proteindecreases phosphorylation 17431108
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased activity of RET proteindecreases activity 17431108
16940797
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of RET mRNAdecreases expression 16951191
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of RET mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 19059307
D012402 Rotenone Rotenone results in decreased expression of RET mRNAdecreases expression 17555550
D012402 Rotenone Rotenone results in decreased expression of RET proteindecreases expression 17555550
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 12634122
D019311 Staurosporine Staurosporine results in decreased expression of RET proteindecreases expression 17555550
D013467 Sulindac Sulindac affects the expression of RET proteinaffects expression 12388792
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RET mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RET mRNAincreases expression 17337447
D014212 Tretinoin RET protein results in increased susceptibility to Tretinoinincreases response to substance 16849523
D014212 Tretinoin Tretinoin results in increased expression of and results in increased phosphorylation of and results in increased activity of RET proteinincreases activity|increases expression|increases phosphorylation 16849523
D014212 Tretinoin Tretinoin results in increased expression of RET mRNAincreases expression 16012519
17431108
D014212 Tretinoin Tretinoin results in increased expression of RET proteinincreases expression 17435603
D014212 Tretinoin Tretinoin results in increased phosphorylation of RET proteinincreases phosphorylation 17431108
D014212 Tretinoin [Tretinoin results in increased secretion of GDNF protein] which results in increased activity of RET proteinincreases activity|increases secretion 16849523
D014700 Verapamil Verapamil affects the expression of RET proteinaffects expression 12388792
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.7714745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.7714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4915322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple imatinib 4.9318322153
MESH:D000022 Abortion, Spontaneous imatinib 5.8418322153
MESH:D000138 Acidosis Ammonium Chloride 3.1918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5717505938
MESH:D058186 Acute Kidney Injury Cisplatin 7.9712690470 17670903 15814532
MESH:D058186 Acute Kidney Injury Sulindac 7.977897758
MESH:D000230 Adenocarcinoma Cisplatin 9.3817638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.3814692618
MESH:D000230 Adenocarcinoma Genistein 9.3811473722
MESH:D000230 Adenocarcinoma Sulindac 9.3811910360
MESH:D000236 Adenoma Diethylnitrosamine 6.326695378 10737359
MESH:D000236 Adenoma Sulindac 6.3210223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.8319061943 18056438 16434500 17620307 19052882 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8316835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.2816460482 11874996 19003578 15623613 12394442 11535846 17611924
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5317306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.2517308373 17451421
MESH:D000505 Alopecia Tretinoin 3.3315955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6311748828
MESH:D000756 Anemia, Sideroblastic manganese chloride 4.6416910769
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.4416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 2.2316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.0516935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.8516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5114601052
MESH:D001859 Bone Neoplasms imatinib 4.9915867366
MESH:D001862 Bone Resorption bisphenol A 3.5411985600
MESH:D001913 Bowen's Disease Sulindac 4.9811207687
MESH:D001930 Brain Injuries Raloxifene 4.1216580743
MESH:D001943 Breast Neoplasms bisphenol A 7.7917123778
MESH:D001943 Breast Neoplasms Calcitriol 7.7911237771
MESH:D001943 Breast Neoplasms Cisplatin 7.7919526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.7917474063
MESH:D001943 Breast Neoplasms Genistein 7.7916541309 17200150 16873071
MESH:D001943 Breast Neoplasms imatinib 7.7917614352
MESH:D001943 Breast Neoplasms Raloxifene 7.7917049068 17595753 17893378 17440819 17952589 16837676 15758505 17242785 15572757 16912660 15775269 17261762
MESH:D001943 Breast Neoplasms Sulindac 7.7916642371
MESH:D001943 Breast Neoplasms Tamoxifen 7.7919200415 19103187 17893378 18351453 20005174 19115204 18997820 20544844 16873071 11161223 19487384 18855134 17049068 19142967 18425577 18629630 19244106 15565566 17440819 16273361 16818667 16202921 21152245 19155303 19288272 20135344 19289846 15668708 20859285 19059307 20390343 20065188 19410462 19189210 18821012 17242785 18815881 21138602 18984771 19084267 17261762 19221464 19011961 19066611 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.7920435547
MESH:D001943 Breast Neoplasms Tretinoin 7.7916873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2216813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4215673190 16097048 10355542 18705752 16124888 15700767 16192424 3786805 15721981 16227642 16011737 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7816168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.0318788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.0317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.0318210153 16328049 18691550 19208518 16681979 17055752 17428255 16288022 10737359 17173139 20007298 10672840 19335982 16502159 20101231 18978308 21159647 16935385 20432363 20514400 16807293 16540662 19822196 16569478 11831363 16698587 19394651 17138121 18665156 20727157 19701751 20214788 18971187 17978847 20084675 19171122 3581430 18506893 17162532 19539802 20935162 18788625 3084413 16830150 19519916 17761372 18785209 19919837 18494052 16878318 19107877 19383236 16779866 18393292 20512989 20524982 19052882 19418558 18056438
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.0316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.0316507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.0316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.031917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9012023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 9.8611237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.8617066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.8618572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.8616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4417572228
MESH:D006332 Cardiomegaly Methazolamide 6.8417124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8416120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 6.6616332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6615775269
MESH:D002386 Cataract Tretinoin 2.8817460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.942727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.9420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2216129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6011677210 17333356 15861022 17681005 17110522 16919318 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.7816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2315340226 15668235 16354765 12621046 8697196
MESH:D002972 Cleft Palate Tretinoin 5.239407595
MESH:D003072 Cognition Disorders Raloxifene 4.2615800139
MESH:D003092 Colitis Tretinoin 3.3517035595
MESH:D003110 Colonic Neoplasms Genistein 3.8517182828
MESH:D003110 Colonic Neoplasms Sulindac 3.8512902858 12458338
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247 18507500
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8715273666
MESH:D015179 Colorectal Neoplasms Sulindac 2.8718059344 10666051 11076880 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7514669216 17141729
MESH:C536209 Congenital central hypoventilation syndrome marker/mechanism
MESH:D019465 Craniofacial Abnormalities decamethrin 6.8819861644
MESH:D019465 Craniofacial Abnormalities imatinib 6.8818322153
MESH:D019465 Craniofacial Abnormalities lead acetate 6.8819769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.889211117 16925845 9224671 9664655 14991402 10589399 9125849 8800419 9142499 17551590
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8517474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5120387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.5116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.0115920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.0119279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.8312861449 17621415
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.5017522070 21278145 11566570 16177239 3732212 19085960 7120509 7440962 3786805 15968718 4309450 6884620 6623471 10915739 19336974 2869522 15998439 7179309 16227642 9327722 10092053 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.5019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5020420201
MESH:D004362 Drug Toxicity Cisplatin 7.2815033597 19839026 12649298 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2811462148
MESH:D004487 Edema imatinib 13.9219703484
MESH:D004487 Edema Raloxifene 13.9215860553
MESH:D004487 Edema Staurosporine 13.928273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.6918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 19.0715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.0715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.0719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2216402032
MESH:D016889 Endometrial Neoplasms Genistein 11.0811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.0816202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 11.0816569247
MESH:D004715 Endometriosis Sulindac 8.1415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1410568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7416302075
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6715173087 16481741 15464296 16785472 17638652
MESH:D004938 Esophageal Neoplasms Sulindac 4.6712235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.9316938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.1816045604 17595544 15959796 19224547 12631006 61145 12795759 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 21.1821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.1815345470
MESH:D005234 Fatty Liver Raloxifene 21.1817473493
MESH:D005234 Fatty Liver Tamoxifen 21.1814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.0319769572
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.7314745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.7314745880
MESH:D018222 Fibromatosis, Aggressive imatinib 17.5517453242
MESH:D018222 Fibromatosis, Aggressive Sulindac 17.5519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 17.5519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 12.6818705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6820067830
MESH:D005355 Fibrosis Tretinoin 12.6817994277
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6611910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3116452187
MESH:D005909 Glioblastoma Genistein 6.4116598420
MESH:D005909 Glioblastoma Tretinoin 6.4117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.0915464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0916096774
MESH:D034381 Hearing Loss Cisplatin 3.9919898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7816084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1215464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.8714991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.2811110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2519110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5415340226 16120746 12621046
MESH:D006627 Hirschsprung Disease marker/mechanism
MESH:D006689 Hodgkin Disease Cisplatin 6.5416200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 6.5412676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6716959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 2.9316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1616899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2116778211
MESH:D006973 Hypertension Raloxifene 7.9915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9918850075 18670907
MESH:D006973 Hypertension Verapamil 7.9917700361
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8217937319
MESH:D007248 Infertility, Male sodium arsenite 5.8212646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 10.3618785209
MESH:D007249 Inflammation Sulindac 10.363291741
MESH:D007249 Inflammation Tamoxifen 10.3619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.3612878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 5.4215189238
MESH:D007333 Insulin Resistance bisphenol A 3.0516393666
MESH:D007410 Intestinal Diseases Tretinoin 3.4117994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 9.2010783313
MESH:D007414 Intestinal Neoplasms Sulindac 9.2010213222 12663524 12628509 12351151 12584176 10223192
MESH:D007417 Intestinal Polyps Sulindac 4.6512394442 11245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8415992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7715464296
MESH:D007674 Kidney Diseases Cadmium Chloride 12.7916962696
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 12.7915369732
MESH:D007674 Kidney Diseases Cisplatin 12.7918289764 19839026 12649298 15190930 12231392
MESH:D007674 Kidney Diseases sodium arsenite 12.7920008137
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4211231351
MESH:D007889 Leiomyoma Raloxifene 4.1616973256
MESH:D007938 Leukemia Genistein 5.7818980019 17468513
MESH:D007938 Leukemia Tretinoin 5.7817143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 4.5015748426 15107311 17301526 19208803
MESH:D007951 Leukemia, Myeloid imatinib 8.8817236224
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.1116766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1116935935 9834237 16766008 17361223 19029980 17294898 17301526 17712046 16140955 17368321 16788101 17217047 19225113 17107899 17506722 19642359 19075265 16891316 12679006 16823087 15748426 19035177 16331271 17339181 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.059224671
MESH:D008064 Lipidoses Tamoxifen 2.8917567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.9216221502 16943688 21278145 16239168 11903743 17157831 11408273 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9218522880 20032147 18665156 18407596 19638242
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.9912468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.0518395914 12666154 15996030 17823541 15370692 15057751 18472094 17944888 18006644 16116963 12898905 12667390 15730626 12445421 12546737 16097048 12649538 18705752 12632514 18429990 14620537 18420326 15818738 17565644 15673190 17976157 17481882 18317297 18187930 16015684 15925388 14716496 17557913 16033810 18472332 18418968 17714472 18156304 15123356 20821823 17766677 18481824 12586293 18166357 17761835 18205269 16027843 15650968 14748882 17525996 18339082 17900296 16136751 16011737 17922224 18395095 16638106 12609069 17698563 10355542 16192424 13678700 17805973 15893842 15338365 14724832 18412020 18263696 12741479 17640975 17631135 15959796 15362042 14716833 12389079 11481614 18054572 15052691 17869086 15876570 17708605 18279442 18376398 17721639 15931870 12632512 16248980 18210741 14512876 18277467 12445418 18251166 12958196
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0517823541
MESH:D008106 Liver Cirrhosis, Experimental imatinib 8.0516596278
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0518397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0415720792 16964402 15830285 17285989 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0417034775
MESH:D008107 Liver Diseases Sulindac 6.0416867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.6519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.6519833225 19690152 20405173 19812893 19073162 18977376 19256749 20583210 19427195 2862719 20118626 19294768 10737359 19996281 18978307 18648771 18644402 21167192 19551842 19254457 15885732 12112319 19090486 2422723 20492335 19255062 18754104 15175105 21047994 20452335 20501860 21278145 19850985 20101389 9163691 19499222 20434301 19638242 19426721 21071580 16942905 20137499 19642983 12771043
MESH:D008113 Liver Neoplasms sodium arsenite 12.6515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 12.6516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.4517942915 19539802 18164116 18308698 17854601 18775883 19004024 16842330 2563599 18544905 3124819 18282651 17174075 19519916 19126423 19009564 18093689 16267830 21159647 18079962 18253720 9362446
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.4512151625
MESH:D008171 Lung Diseases sodium arsenite 2.9319095001
MESH:D008175 Lung Neoplasms Cisplatin 7.8817225452 11798837 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.8821163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 7.8816712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Sulindac 7.8815713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 7.8818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.3212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.3214580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.1719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Cisplatin 9.0018176117 15577323 18505091 17761969 16809738 17023156 12883367 16248763 11135225 18332650 16432458 12393984 12374674
MESH:D008545 Melanoma sodium arsenite 9.0016487513 19082730
MESH:D008545 Melanoma Sulindac 9.0016642371
MESH:D008545 Melanoma Tamoxifen 9.0012393984 19393235
MESH:D008545 Melanoma Tretinoin 9.0016752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.2815990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.2815990972
MESH:D008591 Meningomyelocele Tretinoin 4.0616940565
MESH:D008654 Mesothelioma Cisplatin 3.0917638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1815863610
MESH:D018813 Multiple Endocrine Neoplasia Type 2a marker/mechanism
MESH:D018814 Multiple Endocrine Neoplasia Type 2b marker/mechanism
MESH:D009101 Multiple Myeloma Raloxifene 3.1816497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8717596541
MESH:D009203 Myocardial Infarction Genistein 2.7017141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7312213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.3817141266
MESH:D009232 Myxoma Raloxifene 5.1816343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.763581430 9029167
MESH:D009362 Neoplasm Metastasis imatinib 8.7615867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Cisplatin 7.2816773208
MESH:D009369 Neoplasms sodium arsenite 7.2811559025
MESH:D009369 Neoplasms Tretinoin 7.2816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3120056578
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 9.9417614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.9419200415 19196722 19189210
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1215464296
MESH:D009410 Nerve Degeneration Rotenone 3.6018619942 15790535 17356569
MESH:D009421 Nervous System Malformations bisphenol A 20.5811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.5816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.5814600291
MESH:D009421 Nervous System Malformations Tretinoin 20.589125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.5112854658
MESH:D009436 Neural Tube Defects Tretinoin 6.519142499
MESH:D009447 Neuroblastoma Cisplatin 3.268761367
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 12.7312349958
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.7320387270
MESH:D019636 Neurodegenerative Diseases Sulindac 12.7316850258 17266991
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.338761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7420387270
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4.9916725203
MESH:D010014 Osteolysis imatinib 5.3715867366
MESH:D010024 Osteoporosis Genistein 6.5719401787
MESH:D010024 Osteoporosis Raloxifene 6.5717882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.0216169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.0217893378 15579764 15758505 17823083
MESH:D010049 Ovarian Diseases bisphenol A 4.6211985600
MESH:D010051 Ovarian Neoplasms Cisplatin 10.296897625 17225452 15464296 19769630
MESH:D010051 Ovarian Neoplasms Genistein 10.2919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.2915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 10.2916936753
MESH:D010146 Pain Sulindac 6.133291741
MESH:D010146 Pain Tretinoin 6.1316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.2219003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.2216540662
MESH:D010190 Pancreatic Neoplasms Sulindac 11.2216820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.2215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3511578682
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.7011181820 15451049 16140633
MESH:D010300 Parkinson Disease Rotenone 5.7019114014 16140633 11535288 18619942 15451049 19232380 18191903 16412576 11445065
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.8512349958
MESH:D020734 Parkinsonian Disorders Rotenone 8.8518197244 15795934 15574749 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9615464296
MESH:D010673 Pheochromocytoma marker/mechanism
MESH:D010997 Pleural Neoplasms Cisplatin 4.9717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.252563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.2812476293
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.2910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2911118676 11399792 11896295 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4115572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8716644109 18247401 16289102 15754350 12479363
MESH:D011471 Prostatic Neoplasms Genistein 1.8716925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8715731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011507 Proteinuria Tretinoin 3.2716636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9515861022 16919318
MESH:D011625 Pterygium Tretinoin 4.4216723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4210548101
MESH:D011693 Purpura Raloxifene 5.1815770314
OMIM:164761 REARRANGED DURING TRANSFECTION PROTOONCOGENE marker/mechanism
OMIM:191830 RENAL ADYSPLASIA marker/mechanism
MESH:D051437 Renal Insufficiency Cisplatin 4.0515464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7616283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0814601052
MESH:D012878 Skin Neoplasms sodium arsenite 8.3819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3816192470
MESH:D012878 Skin Neoplasms Tretinoin 8.3816467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9715464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.3116709447
MESH:D013088 Spermatocele Tamoxifen 10.3116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5112854658
MESH:D013274 Stomach Neoplasms Cisplatin 4.4617522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4618456281
MESH:D013274 Stomach Neoplasms imatinib 4.4615786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.4617261132
MESH:D020521 Stroke Raloxifene 3.5316837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6216045194 16684133
MESH:D024801 Tauopathies Camptothecin 5.2616930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.2915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8515669648
OMIM:155240 THYROID CARCINOMA, FAMILIAL MEDULLARY marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5312697716
MESH:D013964 Thyroid Neoplasms marker/mechanism 16940797
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 19.6116940797
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 19.617505956
MESH:D013964 Thyroid Neoplasms imatinib 19.6116940797
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 19.6116940797
MESH:D013964 Thyroid Neoplasms Tretinoin 19.6116026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.8319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4716051514
MESH:D014376 Tuberculosis Tretinoin 3.0016040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.7117225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.7117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.7116452187 17306315 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.718653321 17572228 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.0716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.0711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.0716129372
MESH:D014591 Uterine Diseases bisphenol A 4.6314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5114692618
MESH:D014594 Uterine Neoplasms Sulindac 8.5118645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.2416752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.0617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2114671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7116761959
MESH:D014839 Vomiting Cisplatin 4.3411897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D009396 Wilms Tumor Tretinoin 3.6616287080
Pathway ID Pathway Name
KEGG:04144 Endocytosis
KEGG:05200 Pathways in cancer
KEGG:05216 Thyroid cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34335
    • Releated gene ID Related gene Name
    PA33942PTEN
    Releated disease ID Related disease Name
    PA162372590Renal agenesis
    PA444478Hirschsprung Disease
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01809 - 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
    DB08764 - 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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