AutismKB 2.0

Annotation Detail for REV3L


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Basic Information Top
Gene Symbol:REV3L ( POLZ,REV3 )
Gene Full Name: REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
Band: 6q21
Quick LinksEntrez ID:5980; OMIM: 602776; Uniprot ID:DPOLZ_HUMAN; ENSEMBL ID: ENSG00000009413; HGNC ID: 9968
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of REV3L mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of REV3L mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of REV3L mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of REV3L mRNAincreases expression 19691856
D003474 Curcumin Curcumin results in increased expression of REV3L proteinincreases expression 19137819
D004317 Doxorubicin REV3L protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REV3L mRNAaffects cotreatment|increases expression 17942748
D010656 Phenylephrine Phenylephrine results in decreased expression of REV3L mRNAdecreases expression 18158353
D011374 Progesterone Progesterone results in decreased expression of REV3Ldecreases expression 17510236
C017947 sodium arsenite sodium arsenite results in decreased expression of REV3L mRNAdecreases expression 12377979
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REV3L mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of REV3L mRNAincreases expression 16604517
D014747 Vinblastine REV3L protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1820464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 7.1817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D019973 Alcohol-Related Disorders Curcumin 5.2217887948
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7916807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7916292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Curcumin 3.3618704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615380490 15665606 15845082
MESH:D002545 Brain Ischemia Curcumin 4.4516770732
MESH:D001932 Brain Neoplasms Curcumin 9.2217596214
MESH:D001932 Brain Neoplasms Doxorubicin 9.2217150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0020146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 3.0016243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Doxorubicin 3.0018382427 17983394 15136595 18628466 19526202 15993339 15567936 15668708 16264153 18234424 18695136 16322301 16935488 16096432 15939500 16115903 17426702 15994142 15692762 15634643 17369602 11325840 16595493 16826403
MESH:D001943 Breast Neoplasms Progesterone 3.0016175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 3.0016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D002277 Carcinoma Curcumin 8.5018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.7016234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.701917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0018414057
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.0716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.071485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.5920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 14.5918462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.596189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.5918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.5916051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 7.0217124262 16170337 11179087 11754973 15728586 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0218850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5817131338 17007740 15476868 16455267 17329180 16242529 15792986 17924179 16364871 17382496 16278810 17519947 16731534 16612575 16651473 17974986 16952015 17928571 17351982 15505089 16269455 15811867 17308081 18627295 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9717334414 16243910
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.536135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5320889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.5319524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 17333356 16105132 15861022 17681005 17110522 16919318
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8716354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Curcumin 9.9918200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 9.9917035595
MESH:D003103 Coloboma Curcumin 4.6318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5119359593 16340194
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9518259882 18802399
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9518802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.0018497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4716925845 9224671 9142499 9664655 10589399 14991402 9211117 8800419 9125849 17551590
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4717107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0818204486
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.3617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3620420201
MESH:D004362 Drug Toxicity Doxorubicin 8.3118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3111462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1417351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.3517692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.7617359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7616569247
MESH:D004715 Endometriosis Progesterone 9.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.049664655 16938888
MESH:D005234 Fatty Liver Curcumin 8.1619297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Curcumin 15.4618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.4620067830
MESH:D005355 Fibrosis Tretinoin 15.4617994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8018462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005909 Glioblastoma Curcumin 12.2617596214
MESH:D005909 Glioblastoma Doxorubicin 12.2617150277
MESH:D005909 Glioblastoma Tretinoin 12.2617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 13.3318829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.3315692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 13.3316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.3314991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.5416879835 16330681 17875725 16144979 18006777 14766674 16495754 12587719 16244372 16707910 18674790 17888722 16244371
MESH:D006333 Heart Failure Doxorubicin 3.3917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1417701891
MESH:D006689 Hodgkin Disease Doxorubicin 12.8217606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 12.8212676792
MESH:D006689 Hodgkin Disease Vinblastine 12.8218501091 18180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D006937 Hypercholesterolemia Curcumin 4.1318704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Phenylephrine 5.408949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4018850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.6318502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8215346721 12646999
MESH:D007249 Inflammation Curcumin 8.6116956363 18403477 17151092
MESH:D007249 Inflammation Progesterone 8.6115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2418596194 18200517
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.2910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D007674 Kidney Diseases Doxorubicin 6.4315369732 15699352 16775033
MESH:D007674 Kidney Diseases sodium arsenite 6.4320008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D007889 Leiomyoma Curcumin 4.6618555241
MESH:D007938 Leukemia Curcumin 6.6218462866
MESH:D007938 Leukemia Tretinoin 6.6217143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2816106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2015748426 19642359 19029980 17294898 17368321 16823087 16331271 16935935 19225113 17506722 19035177 17361223 17217047 17712046 16140955 16891316 16766008 12679006 17301526 16788101 9834237 17649720 17339181 17107899 19075265
MESH:D015458 Leukemia, T-Cell Curcumin 4.8616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0617355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.0616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0618397230 16248980
MESH:D008107 Liver Diseases Curcumin 2.6316956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.927678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9221137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 10.9216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.132876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.1316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1312151625
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6918569708 20464547 18816296 18520028 20064080 6695378 20869020 17053015 20135361
MESH:D008175 Lung Neoplasms Curcumin 6.6916243823 19359593 18462866
MESH:D008175 Lung Neoplasms Doxorubicin 6.696189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 6.6916712894 17306315 19931552 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6919555203 11884234
MESH:D008223 Lymphoma Curcumin 7.9818462866
MESH:D008223 Lymphoma Doxorubicin 7.9816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Curcumin 11.9216173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.9215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4015458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4011408345 17203775
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Curcumin 9.9817885582 18462866
MESH:D008545 Melanoma Doxorubicin 9.9816827129
MESH:D008545 Melanoma sodium arsenite 9.9816487513 19082730
MESH:D008545 Melanoma Tretinoin 9.9816752155
MESH:D008545 Melanoma Vinblastine 9.9816248763 18505091 18332650 17761969 12374674 16809738 18176117 16432458 15577320 15577323
MESH:D008569 Memory Disorders Curcumin 4.2517263510
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009101 Multiple Myeloma Curcumin 3.5719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0317962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9815857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4618495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4911141357
MESH:D009369 Neoplasms sodium arsenite 8.4911559025
MESH:D009369 Neoplasms Tretinoin 8.4916946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6712497104
MESH:D009401 Nephrosis Doxorubicin 4.8716899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0716889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.7618462866
MESH:D009436 Neural Tube Defects sodium arsenite 7.4812854658
MESH:D009436 Neural Tube Defects Tretinoin 7.489142499
MESH:D009447 Neuroblastoma Doxorubicin 3.3015555623
MESH:D009503 Neutropenia Vinblastine 4.6617378895
MESH:D009765 Obesity Curcumin 2.7619297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010024 Osteoporosis Curcumin 3.5218719352
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010051 Ovarian Neoplasms Curcumin 11.5319020741 18462866
MESH:D010051 Ovarian Neoplasms Progesterone 11.5317393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.5317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.5316936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.5317440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Clorgyline 1.8819691856
MESH:D011471 Prostatic Neoplasms Curcumin 1.8818156803 10851300 15129424 18769126 18226269 11398177 12497104
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8816868541 18437689 15749863 15897917 16888761 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.6019168576
MESH:D051437 Renal Insufficiency Doxorubicin 4.3317922066
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1110666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012509 Sarcoma Curcumin 9.8318462866
MESH:D012509 Sarcoma Doxorubicin 9.8316767912 18313854 15625365 17203757 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D018805 Sepsis Curcumin 4.1418389075
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.3119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 18.3115692506
MESH:D012878 Skin Neoplasms sodium arsenite 18.3118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.3116192470
MESH:D012878 Skin Neoplasms Tretinoin 18.3116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6716767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4015862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.362093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D013276 Stomach Ulcer Curcumin 3.5819188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.5216010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.1416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.1417053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 16.1418593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 16.1417653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 16.1416452187 16712894 17306315 11723127
MESH:D014565 Urogenital Neoplasms Curcumin 5.3818462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.6711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317334414 17638931 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018