AutismKB 2.0

Annotation Detail for RFC3


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Basic Information Top
Gene Symbol:RFC3 ( MGC5276,RFC38 )
Gene Full Name: replication factor C (activator 1) 3, 38kDa
Band: 13q13.2
Quick LinksEntrez ID:5983; OMIM: 600405; Uniprot ID:RFC3_HUMAN; ENSEMBL ID: ENSG00000133119; HGNC ID: 9971
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03030DNA replication
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
DNA Repair
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500319Activation of ATR in response to replication stress
Related Diseases/Disorders Top
No data
No data
Desease Name
Alzheimer's disease
NEUROLOGICAL
Desease Name
Alzheimer's disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of RFC3 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RFC3 mRNAaffects expression 21346803
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNAaffects cotreatment|affects expression 18720364
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RFC3 mRNAdecreases expression 19150397
20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RFC3 mRNAdecreases expression 15336504
D003345 Corticosterone Corticosterone results in decreased expression of RFC3 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of RFC3 mRNAdecreases expression 20106945
D004317 Doxorubicin RFC3 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RFC3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil RFC3 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein results in increased expression of RFC3 mRNAincreases expression 17341692
C051890 irinotecan irinotecan metabolite results in decreased expression of RFC3 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of RFC3 mRNAdecreases expression 15956246
C051890 irinotecan RFC3 protein results in increased susceptibility to irinotecanincreases response to substance 16734730
D008294 Malathion Malathion results in decreased expression of RFC3 mRNAdecreases expression 16079077
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of RFC3 mRNAincreases expression 20713471
D016685 Mitomycin RFC3 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RFC3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of RFC3 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of RFC3 mRNA]increases expression|increases reaction 17950772
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC3 mRNAaffects cotreatment|increases expression 17942748
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNAaffects cotreatment|affects expression 18720364
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of RFC3 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of RFC3 mRNAdecreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4215322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 8.428333272
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Doxorubicin 10.0217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0214692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.0217638652
MESH:D000230 Adenocarcinoma Genistein 10.0211473722
MESH:D000236 Adenoma Methylcholanthrene 3.456695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000382 Agricultural Workers' Diseases Malathion 4.8917119214 11874814
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.3016510725
MESH:D000740 Anemia Fluorouracil 8.4217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 12.0615885639
MESH:D001169 Arthritis, Experimental Thalidomide 12.069598899
MESH:D001169 Arthritis, Experimental Tretinoin 12.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.7919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.7912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.7916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 4.6711921183
MESH:D001943 Breast Neoplasms Doxorubicin 4.6711325840 16322301 16115903 16935488 17983394 15668708 15136595 15993339 16096432 15692762 17369602 16595493 19526202 17426702 18628466 18234424 16264153 16826403 15939500 18695136 15567936 15634643 18382427 15994142
MESH:D001943 Breast Neoplasms Fluorouracil 4.6716110121 16595493 19217205 18357371 18608205 15136595 16557594
MESH:D001943 Breast Neoplasms Genistein 4.6716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Malathion 4.6712762645
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6717474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002276 Carcinoid Tumor Doxorubicin 12.0816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.0816051944
MESH:D002277 Carcinoma Fluorouracil 13.5717121937
MESH:D002277 Carcinoma Methylcholanthrene 13.5710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5716835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.2216705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.2218059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.2218930000 16332177 16799960 17088986 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.2216924424
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 11.2216313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.221917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.5416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5418695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.466189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.4616757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4616051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717928571 17519947 16731534 17007740 17974986 16364871 15792986 15505089 17924179 17131338 15811867 16109756 17382496 15476868 16278810 16455267 16269455 17329180 16952015 16651473 16612575 18627295 17308081 17351982 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9217334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.2416332659
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.8820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8812371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.8816192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5116835633
MESH:D018281 Cholangiocarcinoma Thalidomide 9.5118291259
MESH:D002779 Cholestasis Cyclosporine 12.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9617333356 11677210 16919318 15861022 17110522 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 12.9619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6416354765 12621046 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Thalidomide 9.6016680017
MESH:D003092 Colitis Tretinoin 9.6017035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8216340194 17725105 17169374 16510598 17172411 15001691 17287894 18772588 17016597 17018589
MESH:D003110 Colonic Neoplasms Genistein 5.8217182828
MESH:D003110 Colonic Neoplasms irinotecan 5.8217287894 17725105
MESH:D015179 Colorectal Neoplasms Azacitidine 4.8019934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8018802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8016391804 17094418 17401013 18448328 16524972 14970324 20501625 17255274 16282729 18509181 15148649 17016601 17695437 18288408 16331619 17454858 18802399 18949393 16303861 15289873 17594712 18383874
MESH:D015179 Colorectal Neoplasms irinotecan 4.8016391804 17454858 15273666 18259882 17159606 16303861 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.489301478
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.229200351
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.859200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.859664655 17551590 9125849 16925845 9142499 8800419 14991402 10589399 9224671 9211117
MESH:D003424 Crohn Disease Thalidomide 4.1216078585
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.0817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0820420201
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.2017359293
MESH:D016889 Endometrial Neoplasms Genistein 12.2011473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.2016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4420426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4416481741 16785472 17638652 16337965 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 12.5219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.5215345470
MESH:D005234 Fatty Liver pirinixic acid 12.5219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8510962813 14633661
MESH:D005355 Fibrosis Cyclosporine 14.2212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2220067830
MESH:D005355 Fibrosis Tretinoin 14.2217994277
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.2212701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 11.6017150277
MESH:D005909 Glioblastoma Genistein 11.6016598420
MESH:D005909 Glioblastoma Tretinoin 11.6017312396
MESH:D005910 Glioma Fluorouracil 6.3516145905
MESH:D005910 Glioma Thalidomide 6.3516327979
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.6315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.6318337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.6316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.389664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.4216707910 16244371 16330681 14766674 18006777 12587719 17875725 16495754 18674790 16244372 17888722 16879835 16144979
MESH:D006333 Heart Failure Doxorubicin 6.8717481944
MESH:D006333 Heart Failure pirinixic acid 6.8720558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9719176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9712621046 16120746 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 3.3318501091 15147373 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 8697196 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1812200463 12878042
MESH:D007249 Inflammation Thalidomide 5.1816134734
MESH:D007333 Insulin Resistance pirinixic acid 2.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6617551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 5.9415369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.9816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9816985049
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.2716514283
MESH:D007938 Leukemia Azacitidine 10.3619148494
MESH:D007938 Leukemia Genistein 10.3617468513 18980019
MESH:D007938 Leukemia Tretinoin 10.3617143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D007951 Leukemia, Myeloid Azacitidine 9.5219077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.5216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.2917596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 6.2918720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.2917596541 16294345 19850784
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.1119299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0915748426 17361223 16766008 17217047 17368321 16788101 16331271 17649720 16891316 17107899 17301526 17294898 17506722 16823087 19029980 19642359 19075265 16140955 19225113 17339181 16935935 9834237 12679006 19035177 17712046
MESH:D017880 Limb Deformities, Congenital Thalidomide 8.3410473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.349224671
MESH:D008103 Liver Cirrhosis Thalidomide 3.9616943688 17174718
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.6116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.6117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 8.6115465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6116248980 18397230
MESH:D008113 Liver Neoplasms Fluorouracil 10.4618383874 16603448 17045692 15113037
MESH:D008113 Liver Neoplasms Mitomycin 10.4615113037
MESH:D008113 Liver Neoplasms pirinixic acid 10.4620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4616984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.6117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.611399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6112151625
MESH:D008175 Lung Neoplasms Azacitidine 6.5121224363
MESH:D008175 Lung Neoplasms Doxorubicin 6.516189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 6.5115246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.5120970405 1399818 9230183 10545420 16337739 11893704 16271038 6695378 7750092 15390079 21163286 20512841 17909032
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5111884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008223 Lymphoma Doxorubicin 3.4016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 13.9211921183
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 13.9212807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.9215458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.9214578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Doxorubicin 5.2016827129
MESH:D008545 Melanoma Thalidomide 5.2016098027 17089043 12829675
MESH:D008545 Melanoma Tretinoin 5.2016752155
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009006 Monosomy Azacitidine 6.0019299654
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5616757204 18986760
MESH:D052016 Mucositis Doxorubicin 12.1317415656
MESH:D052016 Mucositis irinotecan 12.1317159606
MESH:D009101 Multiple Myeloma Azacitidine 7.7919549372 18443271
MESH:D009101 Multiple Myeloma Thalidomide 7.7915920492 15867202 16445831 19112201 19372569 15939924 15744524 17168659 15741222 19112817
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 12.2817596541 19805378 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes Thalidomide 12.2818720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.2817596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.2715857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.2717141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.2719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9918259882
MESH:D009362 Neoplasm Metastasis irinotecan 5.9918259882
MESH:D009369 Neoplasms Fluorouracil 8.0018239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.0017405874
MESH:D009369 Neoplasms Tretinoin 8.0016946489 16594593
MESH:D009401 Nephrosis Doxorubicin 4.6816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0418481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0415640375 16889571
MESH:D009421 Nervous System Malformations Genistein 22.8016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.8014600291
MESH:D009421 Nervous System Malformations Thalidomide 22.8016859833
MESH:D009421 Nervous System Malformations Tretinoin 22.809125849
MESH:D009436 Neural Tube Defects Tretinoin 3.009142499
MESH:D009447 Neuroblastoma Doxorubicin 7.0115555623
MESH:D009447 Neuroblastoma irinotecan 7.018761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.648761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 8.3416436463
MESH:D020258 Neurotoxicity Syndromes Malathion 8.3415081274
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3512819281 16049721
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010051 Ovarian Neoplasms Genistein 7.9119005980
MESH:D010051 Ovarian Neoplasms Thalidomide 7.9116288038
MESH:D010051 Ovarian Neoplasms Tretinoin 7.9116936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.5919003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.5915113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010291 Paresis Thalidomide 6.229200351
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.1817031469
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9118324645
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9118437689 15749863 15897917 16729912 16868541 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9119082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.9116925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Thalidomide 1.9116729912
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011536 Prurigo Thalidomide 6.2212755975
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9316160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012135 Respiratory Sounds Malathion 5.1817119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.4417119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0216283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.9117710206 15675481 16767912 18313854 15625365 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1614601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D019873 Schnitzler Syndrome Thalidomide 5.8516096327
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4718551238
MESH:D012878 Skin Neoplasms Doxorubicin 13.2415692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.248532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2416192470
MESH:D012878 Skin Neoplasms Tretinoin 13.2416467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4817203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4218396642 16951190 16424979 15786421 18567086 17172411 19015929 19084572 17522103 17498489
MESH:D013274 Stomach Neoplasms irinotecan 3.4215723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.4217261132
MESH:D013276 Stomach Ulcer Thalidomide 4.0915138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0816010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0817045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5616280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.5616051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0717653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.1916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases Thalidomide 5.4015741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317678736 17638931 16364871 17334414
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:216 DNA Repair
KEGG:03030 DNA replication
REACT:383 DNA Replication
KEGG:03430 Mismatch repair
KEGG:03420 Nucleotide excision repair
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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