Gene Symbol:	RFX3 ( MGC87155,bA32F11.1 )
Gene Full Name:	regulatory factor X, 3 (influences HLA class II expression)
Band:	9p24.2
Quick Links	Entrez ID:5991; OMIM: 601337; Uniprot ID:RFX3_HUMAN; ENSEMBL ID: ENSG00000080298; HGNC ID: 9984
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D001151	Arsenic	Arsenic results in decreased expression of RFX3 mRNA	decreases expression	16835338
D016572	Cyclosporine	Cyclosporine results in increased expression of RFX3 mRNA	increases expression	20106945

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D018246	Adrenocortical Adenoma		Arsenic	6.28	17306315
MESH:D020261	Arsenic Poisoning	marker/mechanism			16835338
MESH:D020261	Arsenic Poisoning		Arsenic	2.97	16251483 12569548 16835338 18414634
MESH:D050197	Atherosclerosis		Arsenic	3.51	12928151 19371607
MESH:D002280	Carcinoma, Basal Cell		Arsenic	3.83	17687452 15504454
MESH:D006528	Carcinoma, Hepatocellular		Arsenic	2.32	16507464 17306315
MESH:D002294	Carcinoma, Squamous Cell		Arsenic	2.79	17687452 15504454 18922899
MESH:D002295	Carcinoma, Transitional Cell		Arsenic	4.58	18640142
MESH:D002318	Cardiovascular Diseases		Arsenic	3.77	15738583 19152805 17938729
MESH:D002340	Carotid Artery Diseases		Arsenic	4.78	18022660 16973168
MESH:D002471	Cell Transformation, Neoplastic		Cyclosporine	2.85	12371664
MESH:D002779	Cholestasis		Cyclosporine	3.28	19486331
MESH:D005234	Fatty Liver		Cyclosporine	3.40	19224547
MESH:D005355	Fibrosis		Cyclosporine	3.90	12639820 12168785
MESH:D005534	Foot Diseases		Arsenic	6.63	6392382
MESH:D005885	Gingival Hyperplasia		Cyclosporine	5.11	8708960
MESH:D006457	Hemoglobinuria, Paroxysmal		Cyclosporine	5.31	15720958
MESH:D017488	Hyperkeratosis, Epidermolytic		Arsenic	4.96	17050553
MESH:D006973	Hypertension		Arsenic	5.79	16076760 11953799 9931084
MESH:D006973	Hypertension		Cyclosporine	5.79	10903974
MESH:D006987	Hypesthesia		Arsenic	6.63	16093927
MESH:D007638	Keratoconjunctivitis Sicca		Cyclosporine	5.51	15604871
MESH:D007642	Keratosis		Arsenic	5.88	16930632 12749816
MESH:D007674	Kidney Diseases		Cyclosporine	2.58	10903974 8314463 18776723
MESH:D007680	Kidney Neoplasms		Cyclosporine	3.17	12371664
MESH:D015473	Leukemia, Promyelocytic, Acute		Arsenic	3.85	17339181
MESH:D008107	Liver Diseases		Arsenic	2.63	11134558
MESH:D008113	Liver Neoplasms		Arsenic	2.82	16368122
MESH:D008175	Lung Neoplasms		Arsenic	2.21	19168569 17306315 17976673
MESH:D008664	Metal Metabolism, Inborn Errors		Cyclosporine	5.86	16801185
MESH:D017202	Myocardial Ischemia		Arsenic	4.39	15371236
MESH:D009402	Nephrosis, Lipoid		Cyclosporine	5.51	17954296
MESH:D009404	Nephrotic Syndrome		Cyclosporine	3.75	19348381 18481113
MESH:D009436	Neural Tube Defects		Arsenic	3.75	16620997
MESH:D020078	Neurogenic Inflammation		Arsenic	4.98	17056641
MESH:D010051	Ovarian Neoplasms		Arsenic	2.86	17306315
MESH:D010523	Peripheral Nervous System Diseases		Arsenic	4.85	16093927
MESH:D016491	Peripheral Vascular Diseases		Arsenic	5.88	6392382 15371236 16905509
MESH:D011230	Precancerous Conditions		Cyclosporine	3.69	12371664
MESH:D011471	Prostatic Neoplasms		Arsenic	3.54	16140617
MESH:D011507	Proteinuria		Arsenic	4.61	21343184
MESH:D011565	Psoriasis		Cyclosporine	2.35	16882103
MESH:D012871	Skin Diseases	marker/mechanism			16835338
MESH:D012871	Skin Diseases		Arsenic	2.84	15952646 6392382 19834688 17453740 16702368 16759981 18709164 17548696 17938729 16353154 17050553
MESH:D012878	Skin Neoplasms		Arsenic	3.19	17976673 15504454 17029826 19538983 16251483 17050553
MESH:D001749	Urinary Bladder Neoplasms		Arsenic	2.96	11144890 15987713 18640142 17306315 19322015 19429237 17976673
MESH:D014605	Uveitis		Cyclosporine	5.05	1336536
MESH:D014652	Vascular Diseases		Arsenic	5.62	17056641
MESH:D014985	Xerophthalmia		Cyclosporine	5.51	17120751

AutismKB 2.0

Annotation Detail for RFX3

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Syndromic Genes

Non-syndromic Genes

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