Annotation Detail for RFX4
Basic Information
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| Desease ID | Desease Name |
|---|
| 2045 | Bipolar disorder |
| Desease Name |
|---|
| NEUROLOGICAL |
| Cognitive test performance |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of RFX4 mRNA | affects expression | 17562736
|
| D006918 |
Hydroxyurea |
Hydroxyurea results in increased mutagenesis of RFX4 gene | increases mutagenesis | 16868089
|
| D008770 |
Methylnitrosourea |
Methylnitrosourea results in increased mutagenesis of RFX4 gene | increases mutagenesis | 16868089
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of RFX4 mRNA | increases expression | 18301758
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.58 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Methylnitrosourea |
3.19 | 15113128 15688392 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.11 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.57 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.57 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Methylnitrosourea |
3.13 | 16253758 14633655 11306469 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.41 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
8.25 | 10977129 |
| MESH:D002386 |
Cataract |
|
Methylnitrosourea |
8.25 | 12484553 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Methylnitrosourea |
4.05 | 7505956 2727394 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.12 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.57 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.67 | 16781746 15619225 12540782 11421492 19370779 16177239 10663392 11834606 11529661 17906064 11743745 18071297 16393943 14986274 16485898 19420014 19739265 11287661 17562736 19085960 12153990 12958197 19416960 17522070 11739529 10915739 14725611 12594235 12392966 2444490 11461765 15968718 14550746 16081117 18713872 10774834 12705907 19923254 19164858 16109766 16227642 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.82 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.90 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.19 | 20131406 19236843 |
| MESH:D005354 |
Fibrosarcoma |
|
Methylnitrosourea |
5.86 | 11555667 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.40 | 16983495 |
| MESH:D005910 |
Glioma |
|
Methylnitrosourea |
3.69 | 9825942 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.76 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.55 | 19176532 18467677 19772884 16221962 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.02 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.58 | 20558911 |
| MESH:D007248 |
Infertility, Male |
|
Methylnitrosourea |
4.04 | 7193160 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.87 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.40 | 15629191 12587719 |
| MESH:D007951 |
Leukemia, Myeloid |
|
Hydroxyurea |
5.44 | 16532439 |
| MESH:D017880 |
Limb Deformities, Congenital |
|
Methylnitrosourea |
4.48 | 15526292 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.70 | 12587719 19784758 16610002 12969438 11587558 16611625 19014921 19460945 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.63 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.93 | 16377806 15890375 20007298 |
| MESH:D038061 |
Lower Extremity Deformities, Congenital |
|
Methylnitrosourea |
6.03 | 16080182 |
| MESH:D008175 |
Lung Neoplasms |
|
Methylnitrosourea |
2.70 | 18062963 |
| MESH:D008223 |
Lymphoma |
|
Methylnitrosourea |
4.29 | 11418001 16257854 |
| MESH:D016393 |
Lymphoma, B-Cell |
|
Methylnitrosourea |
5.23 | 14633661 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Methylnitrosourea |
3.81 | 10838139 11751437 15113128 15688392 16051031 16944150 14633655 11807958 16827153 15313902 19196723 17131329 12931682 14999141 17020996 16619500 10767621 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.13 | 19513568 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.07 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.27 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.25 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
Methylnitrosourea |
5.80 | 15533788 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.80 | 17405874 |
| MESH:D009374 |
Neoplasms, Experimental |
|
Methylnitrosourea |
5.03 | 12696579 |
| MESH:D009442 |
Neurilemmoma |
|
Methylnitrosourea |
6.12 | 11555667 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.21 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.73 | 16870215 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Methylnitrosourea |
3.47 | 16965848 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Methylnitrosourea |
4.04 | 15682402 12376480 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.55 | 19058328 |
| MESH:D012162 |
Retinal Degeneration |
|
Methylnitrosourea |
4.70 | 18172121 18155124 |
| MESH:D012175 |
Retinoblastoma |
|
Methylnitrosourea |
6.12 | 11555667 |
| MESH:D013274 |
Stomach Neoplasms |
|
Methylnitrosourea |
2.70 | 15930296 16257854 18593901 |
| MESH:D013953 |
Thymus Neoplasms |
|
Methylnitrosourea |
5.86 | 11418001 |
| MESH:D013964 |
Thyroid Neoplasms |
|
Methylnitrosourea |
4.22 | 7505956 3078959 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.44 | 10982225 |
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