AutismKB 2.0

Annotation Detail for RGS4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RGS4 ( DKFZp761F1924,MGC2124,MGC60244,RGP4,SCZD9 )
Gene Full Name: regulator of G-protein signaling 4
Band: 1q23.3
Quick LinksEntrez ID:5999; OMIM: 602516; Uniprot ID:RGS4_HUMAN; ENSEMBL ID: ENSG00000117152; HGNC ID: 10000
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
2198Psychotic disorder
Desease Name
PSYCH
PHARMACOGENOMIC
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RGS4 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine promotes the reaction [eticlopride results in decreased expression of RGS4 mRNA]decreases expression|increases reaction 16539683
D003913 Dextroamphetamine Dextroamphetamine promotes the reaction [SCH 23390 results in increased expression of RGS4 mRNA]increases expression|increases reaction 16539683
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of RGS4 mRNAdecreases expression 12270694
16539683
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of RGS4 proteindecreases expression 16539683
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of RGS4 mRNAincreases expression 12270694
D000661 Amphetamine Amphetamine results in decreased expression of RGS4 mRNAdecreases expression 12638131
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of RGS4 mRNAaffects expression 17331233
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 18164116
D002104 Cadmium Cadmium results in increased expression of RGS4 mRNAincreases expression 21172416
D002118 Calcium RGS4 protein inhibits the reaction [PTAFR protein affects the localization of and affects the abundance of Calcium]affects abundance|affects localization|decreases reaction 11297424
D003024 Clozapine Clozapine results in increased expression of RGS4 mRNAincreases expression 17266109
D003024 Clozapine Clozapine results in increased expression of RGS4 mRNAincreases expression 15860345
D003042 Cocaine Cocaine results in decreased expression of RGS4 mRNAdecreases expression 12270694
D003042 Cocaine Cocaine results in increased expression of RGS4 mRNAincreases expression 12270694
D004041 Dietary Fats Dietary Fats results in increased expression of RGS4 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 18164116
D004178 Diquat Diquat results in increased expression of RGS4 mRNAincreases expression 21172416
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of RGS4 mRNAaffects cotreatment|decreases expression 17404688
C045989 eticlopride Dextroamphetamine promotes the reaction [eticlopride results in decreased expression of RGS4 mRNA]decreases expression|increases reaction 16539683
C045989 eticlopride eticlopride results in decreased expression of RGS4 mRNAdecreases expression 16539683
C045989 eticlopride eticlopride results in decreased expression of RGS4 proteindecreases expression 16539683
D005419 Flavonoids Flavonoids results in increased expression of RGS4 mRNAincreases expression 18035473
D005472 Fluorouracil RGS4 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D006220 Haloperidol Haloperidol results in increased expression of RGS4 mRNAincreases expression 15860345
C119620 kenpaullone kenpaullone results in decreased expression of RGS4 mRNAdecreases expression 17993264
D008694 Methamphetamine Methamphetamine affects the expression of RGS4 mRNAaffects expression 19126440
D009020 Morphine Morphine results in decreased expression of RGS4 mRNAdecreases expression 12270694
D009020 Morphine Morphine results in increased expression of RGS4 mRNAincreases expression 12270694
C030110 oxaliplatin oxaliplatin results in decreased expression of RGS4 mRNAdecreases expression 17762391
C041786 palm oil palm oil results in increased expression of RGS4 mRNAincreases expression 18042831
D010622 Phencyclidine Phencyclidine results in increased expression of RGS4 mRNAincreases expression 17266109
D010656 Phenylephrine RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects cotreatment|affects reaction|increases activity|increases phosphorylation 18977218
D010656 Phenylephrine RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects cotreatment|affects reaction|increases activity|increases phosphorylation 18977218
D010712 Phosphatidic Acids Phosphatidic Acids affects the folding of RGS4 proteinaffects folding 12538649
D010712 Phosphatidic Acids Phosphatidic Acids results in decreased activity of RGS4 proteindecreases activity 12538649
D010716 Phosphatidylinositols RGS4 protein inhibits the reaction [PTAFR protein results in increased hydrolysis of Phosphatidylinositols]decreases reaction|increases hydrolysis 11297424
D010758 Phosphorus Phosphorus results in decreased expression of RGS4 mRNAdecreases expression 17715259
C006253 pirinixic acid pirinixic acid results in decreased expression of RGS4 mRNAdecreases expression 16985257
D010972 Platelet Activating Factor RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]decreases reaction|increases phosphorylation 11297424
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of RGS4 mRNAaffects cotreatment|decreases expression 17404688
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 19059307
C534628 SCH 23390 Dextroamphetamine promotes the reaction [SCH 23390 results in increased expression of RGS4 mRNA]increases expression|increases reaction 16539683
C534628 SCH 23390 SCH 23390 affects the expression of RGS4 proteinaffects expression 16539683
C534628 SCH 23390 SCH 23390 results in increased expression of RGS4 mRNAincreases expression 16539683
D013629 Tamoxifen Tamoxifen affects the expression of RGS4 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of RGS4 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RGS4 mRNAdecreases expression 18691609
D013755 Tetradecanoylphorbol Acetate RGS4 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTAFR protein]decreases reaction|increases phosphorylation 11297424
D013999 Timolol RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects cotreatment|affects reaction|increases activity|increases phosphorylation 18977218
D013999 Timolol RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects cotreatment|affects reaction|increases activity|increases phosphorylation 18977218
C025643 vinclozolin vinclozolin affects the expression of RGS4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Estradiol 4.0911473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.0917638652
MESH:D000236 Adenoma beta-Naphthoflavone 6.1319389873
MESH:D000236 Adenoma Diethylnitrosamine 6.1310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.0717162532 19052882 18056438 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.0716835633
MESH:D000380 Agranulocytosis Clozapine 4.6816160616 14617031 12649775
MESH:D000419 Albuminuria Raloxifene 4.2317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4515800139
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.6716459022 16916582 18475255 15010207
MESH:D000740 Anemia Fluorouracil 7.5915504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000855 Anorexia Amphetamine 4.6812183048 16084549 12005258 16101753
MESH:D001008 Anxiety Disorders vinclozolin 3.3419015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7817460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.5215238619
MESH:D050197 Atherosclerosis Cadmium 3.4215687053
MESH:D001321 Autistic Disorder Haloperidol 2.7819368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D001919 Bradycardia Phenylephrine 4.1615306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 9.7315665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 9.7316580743
MESH:D002545 Brain Ischemia Morphine 4.7619211983
MESH:D001943 Breast Neoplasms Dietary Fats 4.3820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.3817474063
MESH:D001943 Breast Neoplasms Estradiol 4.3812948864 17018787 19861407 18497071 17261762 16675129 17289903 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 4.3819217205 18608205 18357371 16557594 16110121 16595493 15136595
MESH:D001943 Breast Neoplasms Progesterone 4.3816175315 17614352 15562024
MESH:D001943 Breast Neoplasms Raloxifene 4.3817261762 17893378 17595753 15758505 17242785 17049068 16837676 15775269 16912660 17440819 17952589 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 4.3817242785 20390343 18629630 19410462 18997820 19487384 20135344 19059307 17893378 19244106 19084267 19288272 20005174 15565566 19221464 18425577 18984771 20859285 18821012 21138602 19142967 19103187 19189212 17049068 18855134 19289846 16818667 17440819 19066611 16873071 19189210 19011961 16202921 19115204 18815881 20544844 20065188 21152245 19155303 17261762 18351453 16273361 11161223 19200415 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.0019822196 18788625 16698587 20727157 16807293 18971187 19519916 19107877 21159647 10737359 20084675 20512989 19335982 18393292 20007298 20214788 18978308 19418558 11831363 16935385 16540662 18056438 16288022 20432363 16830150 10672840 17173139 17055752 19394651 18210153 20524982 18494052 16779866 16569478 20935162 19052882 18506893 20514400 19171122 19919837 17761372 16878318 17138121 19701751 17428255 19383236 17978847 19539802 3581430 16502159 18785209 18691550 17162532 18665156 16328049 20101231 3084413 19208518 16681979
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.0018930000 17045692 17088986 17971768 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.0016924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5717066447 16280240 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.5718922899
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.4117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4117572228
MESH:D006332 Cardiomegaly Phenylephrine 6.1616170337 15728586 17124262 17287366 11754973 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1815775269
MESH:D002375 Catalepsy Haloperidol 4.531977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Cadmium 9.7917332340
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.7917174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.7918566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.5519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9416354765 15668235 12621046 15340226 8697196
MESH:D019970 Cocaine-Related Disorders Cocaine 5.3319606084
MESH:D003072 Cognition Disorders Clozapine 10.4417123785
MESH:D003072 Cognition Disorders Raloxifene 10.4415800139
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9117018589 16510598 17169374 17725105 17287894 18772588 17016597 15001691 17172411 16340194
MESH:D003110 Colonic Neoplasms oxaliplatin 3.9116510598 16024531 16004971
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8418509181 17695437 15148649 18802399 18288408 18383874 17016601 16282729 17594712 16524972 17454858 16331619 17401013 20501625 15289873 17094418 16303861 18949393 17255274 18448328 14970324 16391804
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.8418509181 18448328 17594712 17401013 17255274 17695437
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 3.9814966744
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.4920210726
MESH:D003704 Dementia Haloperidol 4.2411575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.5516402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5517107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.1819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.1817451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1217187935
MESH:D003967 Diarrhea Morphine 4.172540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1715331141
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.6619107877
MESH:D056486 Drug-Induced Liver Injury Diquat 5.6618164269 18445702
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D050171 Dyslipidemias Clozapine 7.9516402076
MESH:D050171 Dyslipidemias Dietary Fats 7.9518367378
MESH:D004487 Edema pirinixic acid 13.6912083418
MESH:D004487 Edema Raloxifene 13.6915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.6911698051 7812673 16716910 9599246 8113982 8273558 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.3417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.3415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.3419031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.5511473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.5516202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Progesterone 7.8416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8410568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3516337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005221 Fatigue Amphetamine 5.2219890266
MESH:D005234 Fatty Liver Dietary Fats 21.0519004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 21.0521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 21.0520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 21.0517473493
MESH:D005234 Fatty Liver Tamoxifen 21.0519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005355 Fibrosis Dietary Fats 7.3918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3920067830
MESH:D005756 Gastritis Diquat 5.1915046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1315162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.2711110106
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006529 Hepatomegaly pirinixic acid 7.0319176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia oxaliplatin 4.0617418472
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006948 Hyperkinesis Amphetamine 17.111977408 14960337
MESH:D006948 Hyperkinesis Clozapine 17.1116046005
MESH:D006948 Hyperkinesis Methamphetamine 17.1117658665
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006973 Hypertension Phenylephrine 7.8112717712 8949925
MESH:D006973 Hypertension Raloxifene 7.8117577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8118670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.2112791704 18502941
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007248 Infertility, Male Diquat 6.484850670
MESH:D007248 Infertility, Male vinclozolin 6.4816467254
MESH:D007249 Inflammation Dietary Fats 21.0920412841
MESH:D007249 Inflammation Diethylnitrosamine 21.0918785209
MESH:D007249 Inflammation Flavonoids 21.0917296493
MESH:D007249 Inflammation Progesterone 21.0915869954
MESH:D007249 Inflammation Tamoxifen 21.0919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.0912200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 21.098273558 7812673 15177302 7562506 11698051
MESH:D007333 Insulin Resistance Dietary Fats 10.8311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.8316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.8316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007674 Kidney Diseases Cadmium 5.6216962696 16226777 16322080
MESH:D007674 Kidney Diseases Estradiol 5.6215618244
MESH:D007680 Kidney Neoplasms Estradiol 10.6715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.6716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 10.6718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6616316344
MESH:D007889 Leiomyoma Raloxifene 4.1416973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D008064 Lipidoses Clozapine 7.1717567588
MESH:D008064 Lipidoses Tamoxifen 7.1717567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 5.9218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9220032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.4818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.4812878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0117034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 15.9621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.969163691 15175105 19256749 19426721 19638242 18644402 21047994 19551842 10737359 20501860 19833225 19294768 20452335 20583210 19499222 18754104 20492335 19690152 19427195 19850985 2862719 15885732 19812893 20118626 16942905 18648771 19255062 18977376 21071580 2422723 19996281 18978307 12771043 20101389 21278145 20434301 21167192 19254457 12112319 19090486 19642983 20405173 19073162 20137499
MESH:D008113 Liver Neoplasms Fluorouracil 15.9618383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 15.9616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 15.9616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.9616984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 8.4718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.4716842330 19004024 17942915 17174075 18544905 18775883 18308698 18282651 9362446 19009564 18079962 17854601 19519916 16267830 18253720 2563599 18164116 19539802 18093689 21159647 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.4712151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6517365036
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.0220970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 6.0215246190
MESH:D008175 Lung Neoplasms Tamoxifen 6.0218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.0219555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.0211807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.2617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.2611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.2611731420 19196723 14580682 16827153 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.268985016
MESH:D020149 Manganese Poisoning Estradiol 11.3519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3519453300
MESH:D008545 Melanoma Tamoxifen 1.8319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D001523 Mental Disorders Clozapine 7.1116856516
MESH:D001523 Mental Disorders Haloperidol 7.1116856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0316966607 18303189 16166281
MESH:D024821 Metabolic Syndrome X Clozapine 4.1019142101
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1715863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.131613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3418986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.1716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009203 Myocardial Infarction Cocaine 5.5318072171
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009232 Myxoma Raloxifene 5.1716343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.193581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Fluorouracil 4.3416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 4.3417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009421 Nervous System Malformations Estradiol 8.2611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D019636 Neurodegenerative Diseases Amphetamine 7.8115183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D009765 Obesity Clozapine 6.8418515891 19142110
MESH:D009765 Obesity Dietary Fats 6.8420518802 16723640 21332399 18457598 18674790 20132043 19632207 17217161 11836018
MESH:D009765 Obesity pirinixic acid 6.8420558911
MESH:D010024 Osteoporosis Calcium 6.7317882678
MESH:D010024 Osteoporosis Raloxifene 6.7315775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8817823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 4.4419401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.4417393432 16525653
MESH:D010146 Pain Morphine 3.8920225289 15215642 15275824 16273134 18699797 6776300
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.8616540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.8619003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.8615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9212065085 18922899 8330346 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0015687053
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5210923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.232563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2211399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.2219015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Cadmium 1.9117075824
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9119082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9115731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011595 Psychomotor Agitation Haloperidol 4.5811575062
MESH:D011618 Psychotic Disorders Clozapine 13.2415331141
MESH:D011618 Psychotic Disorders Cocaine 13.2416134406
MESH:D011618 Psychotic Disorders Haloperidol 13.2411575062
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8815814490 17365031 17322281 17975199
MESH:D011693 Purpura Raloxifene 5.1715770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6916160472 18722050 15538739 18286688
MESH:D015427 Reperfusion Injury Morphine 6.2419211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.2419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012559 Schizophrenia marker/mechanism
MESH:D012559 Schizophrenia Clozapine 3.8811763009 17667964 20452607 17726453 20521326 20168265 20107430 20580759 18806925 18855531 20521320 16141801 11151749 19369910 17123785
MESH:D012559 Schizophrenia Haloperidol 3.8820107430 18513383 1830565 19369910
MESH:D012640 Seizures Cocaine 3.8010454489
MESH:D012852 Sinusitis Phenylephrine 4.327327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.1912065085 8985016 11807781 8330346 18404319
MESH:D013088 Spermatocele Tamoxifen 3.9016709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.6015862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.6019457130
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.031977408
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3919084572 18567086 19015929 18396642 17172411 16951190 15786421 17522103 16424979 17498489
MESH:D020521 Stroke Raloxifene 3.5216837676
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3520210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.707505956
MESH:D013978 Tibial Fractures Estradiol 12.4219048282
MESH:D013978 Tibial Fractures Raloxifene 12.4219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6616280240
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.7017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.7016712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.5516803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8216837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Clozapine 8.7620564506 16141801 16402076 20521320 17502770 20107430
MESH:D015430 Weight Gain Dietary Fats 8.7616723640
MESH:D015431 Weight Loss Clozapine 4.7017933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34375
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA450882perphenazine
    PA451201quetiapine
    PA451257risperidone
    PA451974ziprasidone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved