AutismKB 2.0

Annotation Detail for RGS7


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Basic Information Top
Gene Symbol:RGS7 ( - )
Gene Full Name: regulator of G-protein signaling 7
Band: 1q43
Quick LinksEntrez ID:6000; OMIM: 602517; Uniprot ID:RGS7_HUMAN; ENSEMBL ID: ENSG00000182901; HGNC ID: 10003
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RGS7 mRNAaffects expression 16483693
D003024 Clozapine alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
D003024 Clozapine [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
D003024 Clozapine Clozapine results in increased expression of RGS7 mRNAincreases expression 18976543
D003474 Curcumin Curcumin results in decreased expression of RGS7 mRNAdecreases expression 17999991
D004958 Estradiol Estradiol results in decreased expression of RGS7 mRNAdecreases expression 20068009
D007657 Ketone Bodies Ketone Bodies results in increased expression of RGS7 mRNAincreases expression 16807920
C079049 MDL 100907 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
C079049 MDL 100907 [[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
C079049 MDL 100907 MDL 100907 results in increased expression of RGS7 mRNAincreases expression 18976543
C076029 olanzapine [[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
C076029 olanzapine olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]affects binding|increases reaction 18976543
C076029 olanzapine olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]affects binding|increases expression|increases reaction 18976543
C076029 olanzapine olanzapine results in increased expression of RGS7 mRNAincreases expression 18976543
C025299 polyphenols polyphenols results in decreased expression of RGS7 mRNAdecreases expression 16293270
D011794 Quercetin Quercetin results in decreased expression of RGS7 mRNAdecreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000380 Agranulocytosis Clozapine 5.2716160616 12649775 14617031
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3517887948
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7716807698
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D050197 Atherosclerosis Curcumin 3.4118704882
MESH:D001321 Autistic Disorder olanzapine 3.3617069543 18685284
MESH:D001327 Autoimmune Diseases Curcumin 11.6019761891
MESH:D001327 Autoimmune Diseases Quercetin 11.6019761891
MESH:D002545 Brain Ischemia Curcumin 4.5716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1017596214
MESH:D001943 Breast Neoplasms Curcumin 2.0118462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Estradiol 2.0112948864 19861407 17289903 18497071 14630087 16675129 17261762 17018787
MESH:D001943 Breast Neoplasms Quercetin 2.0118628248
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Curcumin 3.9718593918
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2219519916 12508355
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0318414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8018462866
MESH:D006332 Cardiomegaly Quercetin 3.4019794523
MESH:D002389 Catatonia olanzapine 6.5116772815 18071103
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D003092 Colitis Curcumin 4.3916804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.7218809619
MESH:D003110 Colonic Neoplasms Curcumin 6.1619359593 16340194
MESH:D003110 Colonic Neoplasms polyphenols 6.1616293270
MESH:D003110 Colonic Neoplasms Quercetin 6.1619440933 11134977 17148506 15741050 16640504 17191121 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D016510 Corneal Neovascularization Curcumin 5.1118497527
MESH:D002658 Developmental Disabilities olanzapine 4.8017069543
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 5.0116402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 5.0118403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.5518204486
MESH:D003928 Diabetic Nephropathies Estradiol 9.5519279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury polyphenols 2.7819370779
MESH:D004381 Duodenal Ulcer Curcumin 4.2517351913
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D005234 Fatty Liver Curcumin 3.8719297423
MESH:D005355 Fibrosis Curcumin 9.8718705752
MESH:D005355 Fibrosis Quercetin 9.8719474275
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9118462866
MESH:D005909 Glioblastoma Curcumin 7.7917596214
MESH:D005909 Glioblastoma Quercetin 7.7919804834
MESH:D005910 Glioma Quercetin 3.1117643826
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7718829502 18462866
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2617701891
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006937 Hypercholesterolemia Curcumin 4.2218704882
MESH:D006943 Hyperglycemia Quercetin 4.1911834736 18262572
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D006963 Hyperphagia olanzapine 6.4717933447
MESH:D006973 Hypertension Quercetin 2.9118356687
MESH:D007249 Inflammation Curcumin 5.8018403477 17151092 16956363
MESH:D007249 Inflammation polyphenols 5.8016366677
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2718596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.3810783313
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007674 Kidney Diseases Estradiol 6.5215618244
MESH:D007674 Kidney Diseases Quercetin 6.5216962696
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007889 Leiomyoma Curcumin 4.7618555241
MESH:D007938 Leukemia Curcumin 6.8918462866
MESH:D007938 Leukemia Quercetin 6.8917468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9616106398
MESH:D008064 Lipidoses Clozapine 4.0817567588
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.7317355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.7312741479
MESH:D008107 Liver Diseases Curcumin 4.6516956363
MESH:D008107 Liver Diseases polyphenols 4.6516698588
MESH:D008113 Liver Neoplasms Quercetin 2.7218980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.1619519916
MESH:D008133 Long QT Syndrome olanzapine 4.8620210726
MESH:D008175 Lung Neoplasms Curcumin 2.8419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Quercetin 2.8416280456
MESH:D008223 Lymphoma Curcumin 3.7118462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9116173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma Curcumin 2.4318462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.3517263510
MESH:D001523 Mental Disorders Clozapine 9.3916856516
MESH:D001523 Mental Disorders olanzapine 9.3916856516
MESH:D008659 Metabolic Diseases olanzapine 5.5619142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D009101 Multiple Myeloma Curcumin 3.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1617962980
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0016810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.0019207477
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5718495463
MESH:D009369 Neoplasms Quercetin 2.8715185748
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 3.8516427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.9018462866
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D009765 Obesity Clozapine 8.0119142110 18515891
MESH:D009765 Obesity Curcumin 8.0119297423
MESH:D009765 Obesity olanzapine 8.0118515891
MESH:D010024 Osteoporosis Curcumin 3.5718719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms Curcumin 8.2619020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 8.2619401270
MESH:D010051 Ovarian Neoplasms Quercetin 8.2619005980
MESH:D010190 Pancreatic Neoplasms Curcumin 5.7617440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Quercetin 5.7616965848
MESH:D011230 Precancerous Conditions Quercetin 4.1319056647
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.6311398177 18769126 18226269 15129424 10851300 18156803 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.6316740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.6314715546 17292933
MESH:D011595 Psychomotor Agitation olanzapine 5.8018685284
MESH:D011618 Psychotic Disorders Clozapine 4.3015331141
MESH:D011656 Pulmonary Emphysema Curcumin 4.6919168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2110666014 18379247
MESH:D012509 Sarcoma Curcumin 4.2818462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012559 Schizophrenia Clozapine 4.4017667964 18855531 20168265 20452607 16141801 11763009 17123785 20521326 11151749 17726453 18806925 20521320 19369910 20107430 20580759
MESH:D012559 Schizophrenia olanzapine 4.4020521326 17726453 20107430
MESH:D018805 Sepsis Curcumin 4.2218389075
MESH:D013276 Stomach Ulcer Curcumin 3.6616631530 19188055
MESH:D017180 Tachycardia, Ventricular olanzapine 5.5320210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.6218593936
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.6216720314
MESH:D014565 Urogenital Neoplasms Curcumin 5.5018462866
MESH:D015430 Weight Gain Clozapine 10.8620107430 16141801 17502770 20521320 16402076 20564506
MESH:D015430 Weight Gain olanzapine 10.8617933447 20107430 19434072
MESH:D015431 Weight Loss Clozapine 5.3117933447
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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