AutismKB 2.0

Annotation Detail for RGS12


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Basic Information Top
Gene Symbol:RGS12 ( DKFZp761K1617,DKFZp761K1817 )
Gene Full Name: regulator of G-protein signaling 12
Band: 4p16.3
Quick LinksEntrez ID:6002; OMIM: 602512; Uniprot ID:RGS12_HUMAN; ENSEMBL ID: ENSG00000159788; HGNC ID: 9994
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of RGS12 mRNAdecreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RGS12 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RGS12 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of RGS12 mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RGS12 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RGS12 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RGS12 mRNAincreases expression 20064835
C014347 decitabine decitabine results in increased expression of RGS12 mRNAincreases expression 19194470
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RGS12 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RGS12 mRNAincreases expression 17108234
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 16.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 16.916695378
MESH:D000236 Adenoma beta-Naphthoflavone 16.9119389873
MESH:D000236 Adenoma Diethylnitrosamine 16.916695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1816434500 19061943 18056438 19052882 17162532 17620307
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9119208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9117474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.677296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6716830150 19107877 19701751 17162532 20007298 19919837 16540662 16935385 20935162 20727157 16288022 18978308 16779866 10672840 19539802 20512989 19052882 18494052 18665156 18788625 20432363 3084413 19171122 17055752 17428255 19208518 16698587 20101231 10737359 20514400 17138121 19383236 17173139 20214788 18971187 18393292 17978847 17761372 20524982 16328049 19394651 16878318 19335982 16502159 3581430 16569478 20084675 18210153 19822196 18056438 11831363 21159647 18691550 19519916 18506893 16681979 19418558 16807293 18785209
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8519215824
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.152727394 17174075 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3617333356 17681005 17110522 15861022 11677210 16105132 16919318
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 2524372 8970840 14531868 11906362 8156756 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4911289319 18289764 18648102 1440618 6482804 9328219 7440962 8291058 16192314 9653073 18692083 6679447 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4917562736 15968718 12392966 19416960 10774834 16109766 18071297 11834606 18713872 11461765 16485898 19164858 14550746 12594235 12705907 11421492 19370779 2444490 11529661 12958197 16393943 19085960 12153990 19739265 12540782 16081117 11287661 16177239 11739529 16781746 10915739 14986274 10663392 17522070 11743745 19420014 15619225 14725611 16227642 17906064 19923254
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4319294695
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3915345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male decitabine 7.1617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007938 Leukemia decitabine 3.1618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2119117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4119010910 18460780 19387464 17679729 18704418 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318665156 19638242 18407596 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 4.0512587719 19784758 16610002 16611625 11587558 19014921 12969438 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9020195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.9019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9018644402 21278145 20434301 20501860 18977376 16942905 15175105 19551842 15885732 21047994 19812893 18754104 19254457 19256749 18648771 19499222 21167192 19833225 19294768 19427195 19850985 12112319 20452335 9163691 20101389 20137499 19073162 19690152 12771043 19090486 18978307 2862719 20583210 20118626 19638242 19426721 10737359 20492335 20405173 21071580 19642983 2422723 19255062 19996281
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.636587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.6318164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.633124819 17854601 18093689 18308698 2563599 16267830 18164116 18079962 19126423 21159647 19519916 19009564 18253720 18775883 9362446 19539802 18282651 18544905 17174075 16842330 17942915 19004024
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4218569708 18816296 20064080 20464547 6695378 18520028 20869020 17053015 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.4220970405 21163286 6695378 20512841
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma decitabine 3.4918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4916882708 19157545 18608210 19010910
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.949029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4111141357
MESH:D009369 Neoplasms decitabine 5.4119470736 17925555 19116145
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms decitabine 2.7019259094 19331143
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D055728 Primary Myelofibrosis decitabine 4.9917616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.462093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.926587162 1399818 7505956 3712494 6582329
MESH:D013964 Thyroid Neoplasms decitabine 12.9217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.927505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.748074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7419087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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