AutismKB 2.0

Annotation Detail for RHAG


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Basic Information Top
Gene Symbol:RHAG ( CD241,RH2,RH50A,Rh50,Rh50GP,SLC42A1 )
Gene Full Name: Rh-associated glycoprotein
Band: 6p12.3
Quick LinksEntrez ID:6005; OMIM: 180297; Uniprot ID:RHAG_HUMAN; ENSEMBL ID: ENSG00000112077; HGNC ID: 10006
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Amine compound SLC transporters
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500358Rhesus glycoproteins mediate ammonium transport.
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00232Hereditary stomatocytosis
Desease IDDesease Name
1909Migraine
2018Rheumatic fever
No data
No data
Desease Name
Anemia, hemolytic, Rh-null, regulator type
Rh-mod syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RHAG mRNAincreases expression 18648102
D000641 Ammonia Ammonia results in decreased expression of RHAG mRNAdecreases expression 18840656
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RHAG mRNAaffects expression 16483693
D002104 Cadmium Cadmium results in increased expression of RHAG mRNAincreases expression 17327700
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of RHAG mRNAincreases expression 17327700
D002245 Carbon Dioxide Carbon Dioxide results in increased expression of RHAG mRNAincreases expression 18840656
D005419 Flavonoids Flavonoids results in decreased expression of RHAG mRNAdecreases expression 18035473
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D050197 Atherosclerosis Cadmium 3.7915687053
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001929 Brain Edema Ammonia 6.7211481608 20217200 19393034
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.617505956
MESH:D002471 Cell Transformation, Neoplastic Cadmium 7.6117332340
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 8.752524372 8156756 14531868 18759878 12868966 11298694 11906362 8970840
MESH:D017449 Dermatitis, Allergic Contact Ammonia 8.7516823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.026482804 6679447 11289319 18648102 9022650 7440962 18692083 9328219 18289764 16192314 9653073 8291058 1440618
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006501 Hepatic Encephalopathy Ammonia 6.1016338762 12420312 20549931
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007249 Inflammation Flavonoids 2.7717296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Cadmium 7.1716322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 7.1716962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.691399818 6587162 598648 3712494
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.7815687053
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Cadmium 3.9617075824
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
OMIM:268150 RH-NULL, REGULATOR TYPE marker/mechanism
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 1399818 7505956 6587162 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.368074119
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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