AutismKB 2.0

Annotation Detail for RHEB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RHEB ( MGC111559,RHEB2 )
Gene Full Name: Ras homolog enriched in brain
Band: 7q36.1
Quick LinksEntrez ID:6009; OMIM: 601293; Uniprot ID:RHEB_HUMAN; ENSEMBL ID: ENSG00000106615; HGNC ID: 10011
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
Pathway IDPathway Name
Signaling by Insulin receptor
Pathway IDPathway Name
200080mTOR signaling pathway
Pathway IDPathway Name
P04397p53 pathway by glucose deprivation
Pathway IDPathway Name
500503Regulation of Rheb GTPase activity by AMPK
500865mTOR signalling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
2127Fibroadenoma
2176Tuberous sclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RHEB mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of RHEB mRNAincreases expression 15890375
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RHEB mRNAincreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of RHEB mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of RHEB mRNAincreases expression 15890375
D000499 Allylamine Allylamine results in increased expression of RHEB mRNAincreases expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RHEB mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RHEB mRNAdecreases expression 15336504
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RHEB mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RHEB mRNAincreases expression 15890375
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RHEB mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHEB mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RHEB mRNAincreases expression 17108234
D008701 Methapyrilene Methapyrilene results in increased expression of RHEB mRNAincreases expression 15890375
D005996 Nitroglycerin Nitroglycerin results in decreased expression of RHEB mRNAdecreases expression 12102619
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of RHEB mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of RHEB mRNAincreases expression 15890375
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHEB mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.5116033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5114692618
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.3416176798
MESH:D000236 Adenoma Dimethylnitrosamine 7.3419555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.0220146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0217129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Dimethylnitrosamine 8.3619555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.583084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.5812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.5816924424 15948411
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9516033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7517110522 16919318 11677210 16105132 15861022 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015668235 16354765 12621046 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5716002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9919420014 16177239 10663392 11743745 16109766 11421492 16485898 17522070 16393943 12705907 16227642 15968718 10774834 19085960 11529661 12540782 12958197 19416960 12594235 11461765 19164858 14725611 19923254 11739529 19370779 18071297 2444490 16781746 17562736 18713872 14986274 17906064 12392966 11287661 14550746 19739265 12153990 10915739 15619225 16081117 11834606
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 8.998172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.4715700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.9117016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.5615345470
MESH:D005234 Fatty Liver pirinixic acid 7.5619236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6616513791 15751030 16534752 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006261 Headache Nitroglycerin 5.2211554966 11284996
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4514722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.2916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.2916569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.3615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.5514681315 16762066 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0717184923
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.4817036385 15942678 14643895 18210741 15723089 17196135 15744066 16270385 18095165 15138612 15099470 15733078 18567088 15086199 15793283 17640959 15571005 16042886 16627068 15864749 15081153 17348192 17198567 15298665 17432682 15161499 17666798 16544323 14568256 18672772 15763062 16603200 15492853 17881167 18637143 18237412 17534399 17203207 17465448 15842777 15577212 14709902 16169303 18371158 14726149 15067225 15479170 15366600 17724770 15591649 15383259 12925901 17201889 12918455 16570917 15339415 18239293 14659978 15504291 17719030 18629640 18364076 16009107 15798949 15369754
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319784758 12969438 19014921 16611625 11587558 16610002 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6917185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.6917457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 30.2915890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 30.2915890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 30.2915890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Diethylstilbestrol 30.2915890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 30.2915890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 30.2915890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 30.2920101389 19690152 15890375 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 30.2915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 30.2916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.928603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 9.9215603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9212151625
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4.9216061637 18508827 9255578 12438228 18813816 14755239 19931552 16401635 17139156 15893417 15172992
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9214755239
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.9211884234 16061637 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9219555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5516002989
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008708 Methemoglobinemia Nitroglycerin 4.743537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.1314659530
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction Nitroglycerin 6.0214729435
MESH:D009203 Myocardial Infarction pirinixic acid 6.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009369 Neoplasms Diethylstilbestrol 5.0415313581
MESH:D009369 Neoplasms pirinixic acid 5.0417405874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.6711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4312819281 16049721
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.4412384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6815687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.6417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6411896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5717136230 15046698 15846301
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5318551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.8216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8216709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3012587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4616033868
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1916049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.1916712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.5116690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5114692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4516002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
REACT:6313 Insulin receptor mediated signaling
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34389
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04137 - Guanosine-5'-Triphosphate
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved