AutismKB 2.0

Annotation Detail for RIT2


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Basic Information Top
Gene Symbol:RIT2 ( RIBA,RIN,ROC2 )
Gene Full Name: Ras-like without CAAX 2
Band: 18q12.3
Quick LinksEntrez ID:6014; OMIM: 609592; Uniprot ID:RIT2_HUMAN; ENSEMBL ID: ENSG00000152214; HGNC ID: 10017
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200128Neurotrophic factor-mediated Trk receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002330 Carmustine Carmustine results in decreased expression of RIT2 mRNAdecreases expression 15980968
D011794 Quercetin Quercetin results in increased expression of RIT2 mRNAincreases expression 15309432
D018038 Sodium Selenite Sodium Selenite results in decreased expression of RIT2 mRNAdecreases expression 18175754
D014635 Valproic Acid Valproic Acid results in increased expression of RIT2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D000743 Anemia, Hemolytic Quercetin 4.6717084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001260 Ataxia Telangiectasia Quercetin 5.6115336622
MESH:D001321 Autistic Disorder Valproic Acid 1.9818558336 18396377 18775368 18940202 19460635 17688650 15238991 17157402 18177632 19232924 17507914 20603192 18316065 18985861 16609825
MESH:D001327 Autoimmune Diseases Quercetin 4.9719761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2417594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D001932 Brain Neoplasms Carmustine 4.7816187019
MESH:D001943 Breast Neoplasms Quercetin 2.6218628248
MESH:D002105 Cadmium Poisoning Quercetin 6.2716962696
MESH:D006528 Carcinoma, Hepatocellular Quercetin 2.3019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.5217234771
MESH:D006332 Cardiomegaly Quercetin 3.5119794523
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D019457 Chromosome Breakage Sodium Selenite 5.3115894690
MESH:D003110 Colonic Neoplasms Quercetin 2.4719440933 16640504 11134977 17191121 15741050 19056647 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9116575769 8888407 17688650
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1516285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0819496084
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.3515131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.351733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.7117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.643922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D005234 Fatty Liver Valproic Acid 3.7214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005355 Fibrosis Quercetin 4.4619474275
MESH:D005909 Glioblastoma Carmustine 8.4116187019
MESH:D005909 Glioblastoma Quercetin 8.4119804834
MESH:D005910 Glioma Quercetin 3.1817643826
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006943 Hyperglycemia Quercetin 4.4318262572 11834736
MESH:D006973 Hypertension Quercetin 2.9718356687
MESH:D007251 Influenza, Human Quercetin 5.2316624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.5214714311
MESH:D007627 Keloid Quercetin 5.5217086741
MESH:D007674 Kidney Diseases Quercetin 3.3016962696
MESH:D007938 Leukemia Quercetin 3.3217468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.2012741479
MESH:D008113 Liver Neoplasms Quercetin 2.7818980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2819519916
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5214737004
MESH:D008545 Melanoma Carmustine 2.9012393984
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D009203 Myocardial Infarction Quercetin 3.1219595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.1019207477
MESH:D009369 Neoplasms Quercetin 2.9615185748
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D020078 Neurogenic Inflammation Quercetin 4.8217929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.6819495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8219005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9616965848
MESH:D011230 Precancerous Conditions Quercetin 4.3519056647
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D011471 Prostatic Neoplasms Quercetin 3.3717292933 14715546
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D019310 Pseudolymphoma Valproic Acid 5.2611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012554 Schistosomiasis japonica Quercetin 6.2716862918
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9916876388 17978042 14763951 11738929 15475178 3137016 1511512 11044598
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9216720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
Pathway ID Pathway Name
REACT:11061 Signalling by NGF
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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