AutismKB 2.0

Annotation Detail for AFAP1


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Basic Information Top
Gene Symbol:AFAP1 ( AFAP,AFAP-110,FLJ56849 )
Gene Full Name: actin filament associated protein 1
Band: 4p16.1
Quick LinksEntrez ID:60312; OMIM: 608252; Uniprot ID:AFAP1_HUMAN; ENSEMBL ID: ENSG00000196526; HGNC ID: 24017
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AFAP1 mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AFAP1 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of AFAP1 mRNAdecreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of AFAP1 mRNAincreases expression 15761015
D016572 Cyclosporine Cyclosporine results in increased expression of AFAP1 mRNAincreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNAaffects cotreatment|decreases expression 15784690
D005492 Folic Acid Folic Acid affects the expression of AFAP1 mRNAaffects expression 17320366
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AFAP1 mRNAaffects binding|increases activity|increases expression 19710929
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNAaffects cotreatment|decreases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.089612607
MESH:D058186 Acute Kidney Injury Folic Acid 4.5316595132 17003819 16316344
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000236 Adenoma Folic Acid 3.9016963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease Folic Acid 3.0817116317
MESH:D001321 Autistic Disorder Folic Acid 2.8221388746
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6919483382
MESH:D001943 Breast Neoplasms Folic Acid 3.1516777985
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9715553829 16217749 11135700 14691202 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0916755160
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D002971 Cleft Lip Folic Acid 4.0721254359
MESH:D002972 Cleft Palate Folic Acid 3.648946559 21254359
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8420501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8417087956 16963246 17116713 16985020 17245555
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1716886840
MESH:D004362 Drug Toxicity Lamivudine 9.2915040536
MESH:D004362 Drug Toxicity Zidovudine 9.2915040536
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1317301261
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D017889 Exfoliation Syndrome Folic Acid 5.7816504073
MESH:D005234 Fatty Liver arsenic trioxide 20.5815073043
MESH:D005234 Fatty Liver Cyclosporine 20.5819224547
MESH:D005234 Fatty Liver pirinixic acid 20.5820131406 19236843
MESH:D005234 Fatty Liver Zidovudine 20.5818299183
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Folic Acid 5.4117171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005901 Glaucoma Folic Acid 5.3016504073
MESH:D006330 Heart Defects, Congenital Folic Acid 3.8917286298 16524890
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006402 Hematologic Diseases Zidovudine 4.9312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006509 Hepatitis B Lamivudine 5.3117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.3115274664 15631357 12044531 16476009 15309715
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 19176532 19772884 16221962
MESH:D015658 HIV Infections Lamivudine 7.389296927 11141242 20032539 17530837
MESH:D015658 HIV Infections Zidovudine 7.3811141242 11363243 17358032 11698656 20032539
MESH:D006679 HIV Seropositivity Folic Acid 5.7817209195
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6816395265 16397167 16433478 16865747 16755160
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1512371664
MESH:D007680 Kidney Neoplasms Zidovudine 8.1512579204
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.5412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.5420370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 19850784 17050201 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416112521 16823087 12018890 17217047 11468182 16891316 15336539 15213294 15748426 17649720 16330433 17869043 16331271 12679006 9834237 15622746 19035177 19225113 19642359 16966277 12712474 11161223 19075265 17107899 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Folic Acid 3.0816877991
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7014682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.8019825857 11798837
MESH:D008175 Lung Neoplasms Zidovudine 2.8018800350
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3817718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.9816832597
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1617358032
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519549372 15949261 11468182 14977855 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009436 Neural Tube Defects arsenic trioxide 8.0610525206
MESH:D009436 Neural Tube Defects Folic Acid 8.0617438019
MESH:D009503 Neutropenia Folic Acid 4.7216322990
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4612452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D051437 Renal Insufficiency Folic Acid 5.0415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012206 Rhabdomyolysis Lamivudine 5.829296927
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Folic Acid 2.9216641680
MESH:D012871 Skin Diseases Folic Acid 3.2918709164
MESH:D013118 Spinal Cord Diseases Folic Acid 5.7816361298
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.6817007042
MESH:D013274 Stomach Neoplasms Folic Acid 3.6817171786
MESH:D013274 Stomach Neoplasms Zidovudine 3.6817696246
MESH:D020521 Stroke Folic Acid 4.4916517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5511780464 12973940 20435036 12845720
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0212579204
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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