AutismKB 2.0

Annotation Detail for BCL6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BCL6 ( BCL5,BCL6A,LAZ3,ZBTB27,ZNF51 )
Gene Full Name: B-cell CLL/lymphoma 6
Band: 3q27.3
Quick LinksEntrez ID:604; OMIM: 109565; Uniprot ID:BCL6_HUMAN; ENSEMBL ID: ENSG00000113916; HGNC ID: 1001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200019Signaling events mediated by HDAC Class II
200091FoxO family signaling
200018IL4-mediated signaling events
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00006Hairy-cell leukemia
Desease IDDesease Name
1934Cancer
2096Otitis media
2103Lymphoproliferative disorder
2148Stomach disease
Desease Name
CANCER
follicular lymphoma
Waldenstrom macroglobulinaemia
lymphoma, follicle center
follicle center lymphoma
No data
Desease Name
Lymphoma, B-cell
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BCL6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of BCL6 mRNAincreases expression 20406850
C026114 2-xylene 2-xylene results in increased expression of BCL6 mRNAincreases expression 20359517
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of BCL6 mRNAincreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of BCL6 mRNAaffects expression 15606129
C430898 AGN 194204 AGN 194204 results in decreased expression of BCL6 mRNAdecreases expression 15302862
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of BCL6 mRNAincreases expression 18687144
D001554 Benzene Benzene results in increased expression of BCL6 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BCL6 mRNAincreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BCL6 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA]increases expression|increases reaction 16006527
D016572 Cyclosporine Cyclosporine results in decreased expression of BCL6 mRNAdecreases expression 20106945
C004912 ethylbenzene ethylbenzene results in increased expression of BCL6 mRNAincreases expression 20359517
C056507 gemcitabine gemcitabine results in increased expression of BCL6 mRNAincreases expression 17039268
C029424 hydrazine hydrazine results in decreased expression of BCL6 mRNAdecreases expression 15282401
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of BCL6 mRNAdecreases expression 19675145
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of BCL6 mRNAincreases expression 20713471
D008752 Methylene Chloride Methylene Chloride results in increased expression of BCL6 mRNAincreases expression 20359517
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of BCL6 mRNAincreases expression 16809437
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCL6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of BCL6 mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in decreased expression of BCL6decreases expression 17510236
D020849 Raloxifene Raloxifene results in increased expression of BCL6 mRNAincreases expression 16497877
C059514 resveratrol resveratrol results in decreased expression of BCL6 proteindecreases expression 17088997
C059514 resveratrol resveratrol results in increased expression of BCL6 mRNAincreases expression 12002526
12569576
C017947 sodium arsenite sodium arsenite results in increased expression of BCL6 mRNAincreases expression 12760830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BCL6 mRNAdecreases expression 18684927
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BCL6 mRNAincreases expression 17035482
D014050 Toluene Toluene results in increased expression of BCL6 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of BCL6 mRNAincreases expression 20359517
D014415 Tunicamycin Tunicamycin results in increased expression of BCL6 mRNAincreases expression 17127020
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of BCL6 mRNAdecreases expression 16330358
D014810 Vitamin E Vitamin E results in decreased expression of BCL6 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5911752688 15322242 14514962
MESH:D058186 Acute Kidney Injury resveratrol 3.6216538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2318653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 10.416695378
MESH:D000236 Adenoma Methylcholanthrene 10.4110545420 6695378
MESH:D000236 Adenoma resveratrol 10.4115688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6417306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.3417308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.2115800139
MESH:D000544 Alzheimer Disease resveratrol 4.2116162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000741 Anemia, Aplastic Benzene 4.1714761424 17661222 11369114
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001169 Arthritis, Experimental resveratrol 3.3417115116
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4511922910
MESH:D050197 Atherosclerosis resveratrol 6.4516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes 2-xylene 11.217457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9616183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 10.1115845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 10.1116580743
MESH:D002545 Brain Ischemia resveratrol 4.0217600658
MESH:D001943 Breast Neoplasms Benzene 6.7217162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7217474063 20146248
MESH:D001943 Breast Neoplasms gemcitabine 6.7218382427 17039268
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.7217474063
MESH:D001943 Breast Neoplasms Methylene Chloride 6.7215986119
MESH:D001943 Breast Neoplasms Progesterone 6.7216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 6.7217893378 16912660 15775269 17242785 15758505 15572757 17440819 17595753 16837676 17261762 17952589 17049068
MESH:D001943 Breast Neoplasms resveratrol 6.7216393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7220435547
MESH:D001943 Breast Neoplasms Trichloroethylene 6.7215986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.0815721981 18705752 15700767 16097048 16192424 3786805 16050911 16124888 16227642 10355542 15673190 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.0816050911
MESH:D002277 Carcinoma Methylcholanthrene 7.6510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.7916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.7916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.793084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.7918788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.7919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.7915276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3316675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1020419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.1016227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1018572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9715775269
MESH:D002318 Cardiovascular Diseases resveratrol 6.9715458977
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.586135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.5812371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 14.5816192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.5820056578 19524636
MESH:D002547 Cerebral Palsy Toluene 5.599294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 7.1219486331
MESH:D002779 Cholestasis pirinixic acid 7.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915340226 12621046 8697196 15668235 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D003092 Colitis resveratrol 3.8716474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4116338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5916507316
MESH:D019465 Craniofacial Abnormalities Benzene 5.2215643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Toluene 5.229294310
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.2219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0318551238
MESH:D003643 Death Toluene 5.406431079
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003872 Dermatitis Benzene 4.5115902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.0916873680
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 8.0916684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.4817451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies resveratrol 8.4816286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.1916109766 11743745 16081117 14550746 11287661 14725611 19739265 18713872 12705907 19416960 18071297 11461765 10915739 16781746 16177239 11739529 15968718 11834606 19085960 12540782 17906064 19923254 14986274 10774834 12153990 16393943 16485898 10663392 16227642 17522070 12958197 12392966 19164858 2444490 15619225 12594235 19420014 19370779 11421492 17562736 11529661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.192869522 15998439 9327722 7179309 19085960 6884620 16227642 15027814 7440962 3732212 16177239 10915739 19336974 10092053 4309450 21278145 15968718 17522070 7120509 6623471 3786805 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.1920420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 14.197120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:C538011 Eales disease Vitamin E 4.449068938
MESH:D004487 Edema pirinixic acid 14.5312083418
MESH:D004487 Edema Raloxifene 14.5315860553
MESH:D004487 Edema resveratrol 14.538985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.0417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.0415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.0417872969
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.179294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1315821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5917923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.8416239168 61145 17595544 12795759 15959796 16045604 12631006 19224547
MESH:D005234 Fatty Liver Cyclosporine 16.8419224547
MESH:D005234 Fatty Liver pirinixic acid 16.8419236843 20131406
MESH:D005234 Fatty Liver Raloxifene 16.8417473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005334 Fever Lipopolysaccharides 3.799205823 11852909
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6810962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 13.2218705752
MESH:D005355 Fibrosis Cyclosporine 13.2212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2220067830
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.3016080930
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006402 Hematologic Diseases Benzene 4.4116183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519110552 19900420
MESH:D006529 Hepatomegaly 2-xylene 13.097457028 7457013
MESH:D006529 Hepatomegaly pirinixic acid 13.0916221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6116490937 16863852
MESH:D006561 Herpes Simplex resveratrol 3.9216876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9412676792
MESH:D019584 Hot Flashes Vitamin E 3.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7815340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia resveratrol 3.7717188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006949 Hyperlipidemias resveratrol 3.7916873680
MESH:D006973 Hypertension Benzene 11.5517940673
MESH:D006973 Hypertension Cyclosporine 11.5510903974
MESH:D006973 Hypertension Raloxifene 11.5515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0717488730
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.6315869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.6317600658
MESH:D007248 Infertility, Male sodium arsenite 2.8212646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 10.879205823 17237260 17963957 12878042 17255318
MESH:D007249 Inflammation Progesterone 10.8715869954
MESH:D007249 Inflammation resveratrol 10.8716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.8712200463 12878042
MESH:D007251 Influenza, Human resveratrol 10.2016624496
MESH:D007251 Influenza, Human Vitamin E 10.2016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4616306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.188314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 13.1820008137
MESH:D007674 Kidney Diseases Vitamin E 13.1812488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.1416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.1416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1412371664
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D007938 Leukemia Benzene 3.2614694614 18335105 17119257 15935818
MESH:D007951 Leukemia, Myeloid Benzene 4.0817506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6519478238
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4116087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.4315821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6721278145 17157831 17334410 16943688 17174718 16239168 11408273 16221502 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3618429990 17922224 15123356 14716496 11481614 15818738 15362042 18420326 18481824 14620537 18339082 18054572 18187930 17761835 18166357 17698563 16116963 18395095 18705752 15052691 15057751 15370692 18317297 15931870 17944888 17708605 12632512 14512876 16192424 17976157 17631135 17481882 17565644 17900296 15996030 15959796 16011737 15925388 16027843 18251166 15650968 16638106 15893842 14748882 10355542 12609069 12586293 18472332 12741479 12666154 17721639 16033810 14724832 17869086 18279442 18277467 17766677 16136751 18205269 14716833 20821823 12649538 18210741 16097048 12546737 18263696 12667390 16015684 13678700 18006644 17525996 12389079 12445421 12445418 17805973 18472094 15673190 17823541 17640975 18376398 17714472 12632514 15876570 15338365 12958196 18395914 18418968 18156304 17557913 18412020 15730626 12898905 16248980
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.3612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.3616169303
MESH:D008107 Liver Diseases Acetaminophen 3.6619784758 16611625 19014921 12969438 19460945 11587558 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.6616964402 15830285 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6514706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.347678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.3421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.3419294768
MESH:D008113 Liver Neoplasms pirinixic acid 20.3416377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 20.3420405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 20.3415276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.276135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Benzene 21.2712562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.2712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 21.271399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.2712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 21.277955063
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D008171 Lung Diseases Vitamin E 6.8616863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5414698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.4517365036
MESH:D055370 Lung Injury Lipopolysaccharides 8.4521114838
MESH:D008175 Lung Neoplasms Benzene 10.1712562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.1718569708 17053015 20464547 20869020 18816296 18520028 20135361 6695378 20064080
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.1716271038 10545420 9230183 21163286 15390079 1399818 16337739 6695378 7750092 20512841 20970405 17909032 11893704
MESH:D008175 Lung Neoplasms Methylene Chloride 10.1715172992
MESH:D008175 Lung Neoplasms sodium arsenite 10.1717077188 15276417 17306315 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 10.1711062179
MESH:D008223 Lymphoma Benzene 3.5517119257 17584886
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6614749477
MESH:D016399 Lymphoma, T-Cell marker/mechanism 15375218
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.3812562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3815688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.1711921183
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.1717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.178985016 11606380
MESH:D008545 Melanoma resveratrol 3.3417992120
MESH:D008545 Melanoma sodium arsenite 3.3416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008607 Mental Retardation Toluene 3.569294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0818303189 16166281 16966607
MESH:D008659 Metabolic Diseases resveratrol 4.1417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D019957 Motor Skills Disorders Toluene 4.999294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9916381670
MESH:D009101 Multiple Myeloma Benzene 11.1917119195
MESH:D009101 Multiple Myeloma Raloxifene 11.1916497877
MESH:D009101 Multiple Myeloma resveratrol 11.1916490592 17164350 14749477 16267019 17935668 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.3719151258
MESH:D009203 Myocardial Infarction resveratrol 5.3717015251 17125593 17188708 16317513 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.3317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7516411023
MESH:D009205 Myocarditis resveratrol 4.5017322642
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.4718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.477678174 18551238
MESH:D009369 Neoplasms 4-phenylbutyric acid 14.3719116145
MESH:D009369 Neoplasms Benzo(a)pyrene 14.3711141357
MESH:D009369 Neoplasms pirinixic acid 14.3717405874
MESH:D009369 Neoplasms sodium arsenite 14.3711559025
MESH:D009369 Neoplasms Trichloroethylene 14.3711911487
MESH:D009374 Neoplasms, Experimental resveratrol 8.378985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.3720056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9614600291
MESH:D009436 Neural Tube Defects Benzene 6.9815643154
MESH:D009436 Neural Tube Defects sodium arsenite 6.9812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6518514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1617929310
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.8516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.8516049721
MESH:D009784 Occupational Diseases Benzene 13.8515612468 15913788 15576619 15727169 17119257 17178637 15935809 16737584 17479406
MESH:D010024 Osteoporosis Raloxifene 3.2415775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.4017893378 15579764 17823083 15758505
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.4017513867
MESH:D010051 Ovarian Neoplasms Benzene 7.5012562636
MESH:D010051 Ovarian Neoplasms Progesterone 7.5016525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.5015276417 17306315
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms gemcitabine 3.4417440100 18992248 11504793 18383843 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6310923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.2912224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0012371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.7216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7211399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms AGN 194204 1.8816000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms resveratrol 1.8815767336 17636462 17718901 17675339 16731767 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9315814490 17975199 17365031 17322281
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3216325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1419058328
MESH:D015427 Reperfusion Injury resveratrol 6.1416317513 16314181 15827377 17520802 17058453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 8.9218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.9218551238
MESH:D012640 Seizures Toluene 8.926431079 9294310
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5410029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 12.548985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 12.5419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5416192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.0216503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms Benzene 2.5112562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5120155912 2093021
MESH:D020521 Stroke Raloxifene 8.0316837676
MESH:D020521 Stroke Vitamin E 8.0316517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2516321402
MESH:D013733 Testicular Diseases Toluene 4.6910514026 10048760
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9415821434
MESH:D013953 Thymus Neoplasms Benzene 4.6910850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013978 Tibial Fractures Raloxifene 4.9419048282
MESH:D014062 Tongue Neoplasms resveratrol 3.9816227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.6816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.6816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.6817053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.6817572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.6816712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1110091137
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.8117473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.8111813266
MESH:D014594 Uterine Neoplasms Benzene 9.0412562636
MESH:D014594 Uterine Neoplasms resveratrol 9.0417044934
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0417488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25312
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450218levonorgestrel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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