Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
C548651 |
2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester |
2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EXOC4 mRNA | decreases expression | 19933214
|
D016604 |
Aflatoxin B1 |
Aflatoxin B1 affects the expression of EXOC4 protein | affects expression | 20106945
|
D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of EXOC4 mRNA | decreases expression | 20106945 20064835
|
D002251 |
Carbon Tetrachloride |
Carbon Tetrachloride affects the expression of EXOC4 mRNA | affects expression | 17484886
|
C051890 |
irinotecan |
irinotecan analog results in decreased expression of EXOC4 mRNA | decreases expression | 18927307
|
D009151 |
Mustard Gas |
Mustard Gas results in increased expression of EXOC4 mRNA | increases expression | 15674844
|
C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of EXOC4 mRNA | decreases expression | 18445702
|
D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin results in decreased expression of EXOC4 mRNA | decreases expression | 19933214
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.18 | 14514962 11752688 15322242 |
MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.38 | 18653653 |
MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.03 | 20127859 20464547 |
MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.78 | 6695378 |
MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
11.05 | 16434500 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
11.05 | 16835633 |
MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.17 | 11748828 |
MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.38 | 19183758 |
MESH:D001249 |
Asthma |
|
Mustard Gas |
2.77 | 10378619 |
MESH:D001768 |
Blister |
|
Mustard Gas |
5.50 | 19167455 |
MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
9.59 | 19483382 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
9.59 | 12125929 |
MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.17 | 15340226 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.91 | 15746008 |
MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.87 | 20146248 17474063 |
MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.87 | 20435547 |
MESH:D001989 |
Bronchiolitis Obliterans |
|
Mustard Gas |
5.50 | 15286001 |
MESH:D029481 |
Bronchitis, Chronic |
|
Mustard Gas |
5.35 | 17687719 10378619 |
MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Carbon Tetrachloride |
4.08 | 10355542 16192424 15673190 16124888 15700767 16011737 3786805 16050911 15721981 18705752 16227642 16097048 |
MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
2.99 | 16835633 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Aflatoxin B1 |
3.15 | 12619106 21507988 12907637 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Carbon Tetrachloride |
3.15 | 18788625 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.10 | 20419170 |
MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.49 | 18850075 18670907 16120746 |
MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.38 | 16835633 |
MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.00 | 19176532 |
MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.19 | 15668235 15340226 16354765 8697196 12621046 |
MESH:D003110 |
Colonic Neoplasms |
|
irinotecan |
2.62 | 17287894 17725105 |
MESH:D015179 |
Colorectal Neoplasms |
|
irinotecan |
2.36 | 18259882 18509181 17159606 17454858 16391804 15273666 16303861 |
MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.27 | 17141729 14669216 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.26 | 20055451 10048152 15322242 |
MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.52 | 18249437 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.71 | 17107852 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Carbon Tetrachloride |
3.92 | 10915739 9327722 7440962 3732212 21278145 17522070 19085960 15968718 16177239 4309450 2869522 3786805 16227642 10092053 6884620 15027814 19336974 7120509 7179309 15998439 11566570 6623471 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
3.92 | 20420201 |
MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
2.93 | 11462148 |
MESH:D004487 |
Edema |
|
Mustard Gas |
12.87 | 11402378 9260866 11428647 11428631 |
MESH:D004487 |
Edema |
|
pirinixic acid |
12.87 | 12083418 |
MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
12.87 | 12711302 11000095 |
MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.28 | 15322242 18230668 16714409 |
MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.25 | 10568697 9294722 |
MESH:D004890 |
Erythema |
|
Mustard Gas |
5.50 | 9357497 |
MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.06 | 16530937 |
MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.19 | 11564622 |
MESH:D005234 |
Fatty Liver |
|
Carbon Tetrachloride |
8.49 | 12795759 12631006 17595544 16239168 15959796 16045604 19224547 61145 |
MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
8.49 | 20131406 19236843 |
MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.76 | 11858732 |
MESH:D005355 |
Fibrosis |
|
Carbon Tetrachloride |
9.64 | 18705752 |
MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
9.64 | 20067830 |
MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
4.97 | 10696789 |
MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
6.82 | 20471113 |
MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
6.82 | 10048152 11294989 |
MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.67 | 20558911 |
MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.58 | 11000095 |
MESH:D006505 |
Hepatitis |
|
Carbon Tetrachloride |
3.88 | 19900420 19110552 |
MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
9.30 | 19176532 16221962 18467677 19772884 |
MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
9.30 | 16120746 15340226 12621046 |
MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.42 | 18606429 16354765 15340226 16959395 8697196 |
MESH:D006932 |
Hyperbilirubinemia |
|
Carbon Tetrachloride |
4.87 | 16899240 |
MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.41 | 20558911 |
MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
1.98 | 18670907 18850075 |
MESH:D006975 |
Hypertension, Portal |
|
Carbon Tetrachloride |
4.39 | 15338365 |
MESH:D007249 |
Inflammation |
|
Mustard Gas |
5.42 | 9357497 8975870 11428631 11428620 11402378 9260866 11428647 17524151 16001271 |
MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
5.42 | 12200463 12878042 |
MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.78 | 16306350 |
MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.58 | 16580747 |
MESH:D008103 |
Liver Cirrhosis |
|
Carbon Tetrachloride |
2.92 | 11903743 11408273 17334410 16943688 21278145 16239168 17174718 17157831 16221502 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Carbon Tetrachloride |
3.51 | 13678700 12649538 17766677 14748882 18187930 18472332 17631135 15931870 15818738 15650968 16192424 18395914 17708605 18251166 17761835 17805973 12958196 12898905 12632512 16015684 17900296 12445418 16116963 16248980 12667390 12632514 18420326 12389079 15057751 17823541 12741479 18210741 17525996 17698563 12609069 14716496 18395095 15673190 12586293 12666154 18705752 15730626 17976157 17481882 16011737 18054572 18317297 15338365 18418968 11481614 14716833 18277467 18263696 18376398 18339082 18006644 15959796 12546737 18156304 18412020 18279442 17922224 17721639 16638106 18429990 16136751 10355542 15925388 14724832 18472094 15362042 20821823 16027843 17869086 18481824 14620537 15052691 17557913 17944888 17714472 15996030 15893842 18166357 14512876 15123356 15370692 18205269 17565644 16033810 15876570 16097048 17640975 12445421 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
3.51 | 15474484 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
3.51 | 12878042 |
MESH:D008107 |
Liver Diseases |
|
Carbon Tetrachloride |
2.13 | 16246199 15720792 15830285 17285989 16964402 |
MESH:D017093 |
Liver Failure |
|
Carbon Tetrachloride |
4.47 | 15123358 |
MESH:D017114 |
Liver Failure, Acute |
|
Carbon Tetrachloride |
3.92 | 14706259 16899240 |
MESH:D008113 |
Liver Neoplasms |
|
Aflatoxin B1 |
15.08 | 2125692 18177683 9163691 15890375 |
MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
15.08 | 20195826 21137059 |
MESH:D008113 |
Liver Neoplasms |
|
Carbon Tetrachloride |
15.08 | 19294768 |
MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
15.08 | 15890375 20007298 16377806 |
MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
15.08 | 16984957 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Aflatoxin B1 |
10.64 | 8603461 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Carbon Tetrachloride |
10.64 | 15583823 12014681 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
10.64 | 12151625 |
MESH:D008171 |
Lung Diseases |
|
Mustard Gas |
3.60 | 18702808 18161513 |
MESH:D008175 |
Lung Neoplasms |
|
Aflatoxin B1 |
5.03 | 14755239 |
MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
5.03 | 18816296 6695378 18569708 20135361 18520028 20464547 20869020 17053015 20064080 |
MESH:D008175 |
Lung Neoplasms |
|
Mustard Gas |
5.03 | 8781369 3148597 |
MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
5.03 | 19555203 11884234 |
MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.37 | 16381670 |
MESH:D052016 |
Mucositis |
|
irinotecan |
5.35 | 17159606 |
MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.81 | 16239165 |
MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.22 | 19151258 |
MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.21 | 12213967 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.13 | 16411023 |
MESH:D009362 |
Neoplasm Metastasis |
|
irinotecan |
3.25 | 18259882 |
MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
5.17 | 11141357 |
MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.17 | 17405874 |
MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.49 | 14600291 |
MESH:D009447 |
Neuroblastoma |
|
irinotecan |
3.59 | 8761367 |
MESH:D017599 |
Neuroectodermal Tumors |
|
irinotecan |
5.07 | 8761367 |
MESH:D009503 |
Neutropenia |
|
Mustard Gas |
4.23 | 16761898 7688884 |
MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.62 | 12520081 |
MESH:D011041 |
Poisoning |
|
Mustard Gas |
4.06 | 15727166 |
MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
3.84 | 18163543 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
3.53 | 11118676 11896295 11222880 11399792 |
MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.93 | 17292933 |
MESH:D011537 |
Pruritus |
|
Mustard Gas |
4.43 | 18058305 |
MESH:D011658 |
Pulmonary Fibrosis |
|
Mustard Gas |
3.00 | 17720292 17266442 17620002 17894541 10334151 |
MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.49 | 19058328 |
MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.12 | 18990726 |
MESH:D012871 |
Skin Diseases |
|
Mustard Gas |
2.76 | 12880345 16961503 15451306 |
MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
5.80 | 10029692 19755658 |
MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
5.80 | 16192470 |
MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
2.60 | 2093021 20155912 |
MESH:D013274 |
Stomach Neoplasms |
|
irinotecan |
2.60 | 15723263 |
MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.28 | 12697716 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.25 | 17053015 |
MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
4.97 | 12125929 |
MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.62 | 15886252 |