AutismKB 2.0

Annotation Detail for EXOC4


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Basic Information Top
Gene Symbol:EXOC4 ( MGC27170,REC8,SEC8,SEC8L1,Sec8p )
Gene Full Name: exocyst complex component 4
Band: 7q33
Quick LinksEntrez ID:60412; OMIM: 608185; Uniprot ID:EXOC4_HUMAN; ENSEMBL ID: ENSG00000131558; HGNC ID: 30389
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04530Tight junction
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200012Insulin Pathway
200046Arf6 trafficking events
No data
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
Desease Name
rheumatoid arthritis
IMMUNE
tonometry
Desease Name
Tonometry
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EXOC4 mRNAdecreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EXOC4 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EXOC4 mRNAdecreases expression 20106945
20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of EXOC4 mRNAaffects expression 17484886
C051890 irinotecan irinotecan analog results in decreased expression of EXOC4 mRNAdecreases expression 18927307
D009151 Mustard Gas Mustard Gas results in increased expression of EXOC4 mRNAincreases expression 15674844
C006253 pirinixic acid pirinixic acid results in decreased expression of EXOC4 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EXOC4 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0810355542 16192424 15673190 16124888 15700767 16011737 3786805 16050911 15721981 18705752 16227642 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1512619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 16354765 8697196 12621046
MESH:D003110 Colonic Neoplasms irinotecan 2.6217287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3618259882 18509181 17159606 17454858 16391804 15273666 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9210915739 9327722 7440962 3732212 21278145 17522070 19085960 15968718 16177239 4309450 2869522 3786805 16227642 10092053 6884620 15027814 19336974 7120509 7179309 15998439 11566570 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Mustard Gas 12.8711402378 9260866 11428647 11428631
MESH:D004487 Edema pirinixic acid 12.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4912795759 12631006 17595544 16239168 15959796 16045604 19224547 61145
MESH:D005234 Fatty Liver pirinixic acid 8.4920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.3019176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3016120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16354765 15340226 16959395 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Mustard Gas 5.429357497 8975870 11428631 11428620 11402378 9260866 11428647 17524151 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211903743 11408273 17334410 16943688 21278145 16239168 17174718 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5113678700 12649538 17766677 14748882 18187930 18472332 17631135 15931870 15818738 15650968 16192424 18395914 17708605 18251166 17761835 17805973 12958196 12898905 12632512 16015684 17900296 12445418 16116963 16248980 12667390 12632514 18420326 12389079 15057751 17823541 12741479 18210741 17525996 17698563 12609069 14716496 18395095 15673190 12586293 12666154 18705752 15730626 17976157 17481882 16011737 18054572 18317297 15338365 18418968 11481614 14716833 18277467 18263696 18376398 18339082 18006644 15959796 12546737 18156304 18412020 18279442 17922224 17721639 16638106 18429990 16136751 10355542 15925388 14724832 18472094 15362042 20821823 16027843 17869086 18481824 14620537 15052691 17557913 17944888 17714472 15996030 15893842 18166357 14512876 15123356 15370692 18205269 17565644 16033810 15876570 16097048 17640975 12445421
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 15720792 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 15.082125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.0819294768
MESH:D008113 Liver Neoplasms pirinixic acid 15.0815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.648603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6412151625
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0318816296 6695378 18569708 20135361 18520028 20464547 20869020 17053015 20064080
MESH:D008175 Lung Neoplasms Mustard Gas 5.038781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0319555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D052016 Mucositis irinotecan 5.3517159606
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis irinotecan 3.2518259882
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma irinotecan 3.598761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.078761367
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017720292 17266442 17620002 17894541 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 16961503 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.602093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.6015723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134944654
  • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018