AutismKB 2.0

Annotation Detail for BRD2


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Basic Information Top
Gene Symbol:BRD2 ( D6S113E,DKFZp686N0336,FLJ31942,FSH,FSRG1,KIAA9001,NAT,RING3,RNF3 )
Gene Full Name: bromodomain containing 2
Band: 6p21.32
Quick LinksEntrez ID:6046; OMIM: 601540; Uniprot ID:BRD2_HUMAN; ENSEMBL ID: ENSG00000204256; HGNC ID: 1103
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200191Regulation of retinoblastoma protein
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1700Mitochondrial encephalomyopathies
1799Epilepsy
1966Myoclonic epilepsy, Juvenile
1814Myoclonic epilepsies, Progressive
2239Lymphoma
Desease Name
photoparoxysmal response
NEUROLOGICAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BRD2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BRD2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BRD2 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BRD2 mRNAincreases expression 19150397
C444299 diindolylmethane diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]decreases reaction|increases expression 11179685
D004958 Estradiol diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]decreases reaction|increases expression 11179685
D004958 Estradiol Estradiol results in increased expression of BRD2 mRNAincreases expression 11179685
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]decreases reaction|increases expression 11179685
C002950 methylformamide methylformamide analog results in increased expression of BRD2 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of BRD2 mRNAincreases expression 17040096
D010634 Phenobarbital Phenobarbital results in decreased expression of BRD2 mRNAdecreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of BRD2 mRNAincreases expression 16985257
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of BRD2 mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of BRD2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]decreases reaction|increases expression 11179685
C025643 vinclozolin vinclozolin affects the expression of BRD2 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of BRD2 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of BRD2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5715322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.7917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7917261762 12948864 18497071 17289903 17018787 16675129 19861407 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.623084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6217173139 1701930 20935162 20007298 6705139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 8697196 12621046 16354765 15668235
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0818713872 11421492 19370779 10915739 11743745 14725611 11739529 11834606 12594235 11529661 17562736 12705907 19164858 10663392 16393943 19739265 19923254 11287661 2444490 12540782 16485898 14986274 15619225 12153990 16109766 16227642 12392966 14550746 19085960 17906064 15968718 11461765 16177239 19416960 16081117 18071297 10774834 17522070 12958197 16781746 19420014
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0118566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver pirinixic acid 2.8220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Phenobarbital 14.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.8218467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8215340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.0716467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812200463 12878042
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance Estradiol 7.3116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 10.2115629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.2115618244
MESH:D007674 Kidney Diseases Vitamin E 10.2112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5116705839
MESH:D007680 Kidney Neoplasms Estradiol 7.5115610895
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9221047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9716169303
MESH:D008107 Liver Diseases Acetaminophen 3.9719014921 12587719 19784758 16610002 12969438 16611625 19460945 11587558
MESH:D008107 Liver Diseases Phenobarbital 3.9719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8320195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 10.8319073162 8742319 19482888 21047994 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 10.8315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8316984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.906150874 18308698 2563599 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3920464547 20064080 6695378 20869020 18520028 18816296 20135361 18569708 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.3911062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1316891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1315318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4812819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7711118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.7719015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5215084515
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures Phenobarbital 6.054039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.091399818
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25414
    • No data
    No data
    Releated drug ID Related drug Name
    PA451998arylhydrazines
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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